Results 1 to 10 of about 821,509 (184)
Galectin-1 promotes gastric cancer peritoneal metastasis through peritoneal fibrosis
BMC Cancer, 2023 Background Peritoneal metastasis is one of the main causes of death in patients with gastric cancer (GC). Galectin-1 regulates various undesirable biological behaviors in GC and may be key in GC peritoneal metastasis. Methods In this study, we elucidated
Xianhe Shen +8 more
doaj +4 more sources
EBioMedicine, 2023 Summary: Peritoneal metastasis is a challenging aspect of clinical practice for gastric cancer. Animal models are crucial in understanding molecular mechanisms, assessing drug efficacy, and conducting clinical intervention studies, including those ...
Zehui Li +3 more
doaj +2 more sources
CXCL8 and the peritoneal metastasis of ovarian and gastric cancer
Frontiers in Immunology, 2023 CXCL8 is the most representative chemokine produced autocrine or paracrine by tumor cells, endothelial cells and lymphocytes. It can play a key role in normal tissues and tumors by activating PI3K-Akt, PLC, JAK-STAT, and other signaling pathways after ...
Xuanrong Fu +3 more
doaj +2 more sources
Tumor microenvironment in ovarian cancer peritoneal metastasis
Cancer Cell International, 2023 Ovarian cancer (OC) is one of the most common gynecological malignancies with high morbidity and mortality. The peritoneum is one of the most common metastatic sites in ovarian cancer, involving large amounts of ascites. However, its mechanism is unclear.
Shuangshuang Mei +3 more
semanticscholar +4 more sources
HAPLN1 potentiates peritoneal metastasis in pancreatic cancer
Nature Communications, 2023 Pancreatic ductal adenocarcinoma (PDAC) frequently metastasizes into the peritoneum, which contributes to poor prognosis. Metastatic spreading is promoted by cancer cell plasticity, yet its regulation by the microenvironment is incompletely understood ...
Lena Wiedmann +17 more
semanticscholar +7 more sources
Predictors of peritoneal metastasis of gastric origin
Journal of the Egyptian National Cancer Institute, 2022 Background Gastric adenocarcinoma is one of the most aggressive forms of cancer. Despite marked advancements in radiological techniques, peritoneal deposits are still only discovered during laparotomies in a significant number of cases.
Mohamed Atef ElKordy +4 more
doaj +3 more sources
METTL3 promotes peritoneal metastasis of colorectal cancer through regulating m6A modification of NRXN3 mRNA [PDF]
iScienceSummary: Colorectal cancer (CRC) is a prevalent digestive system malignancy accompanied by peritoneal metastasis occurring in 7% of cases. Methyltransferase-like 3 (METTL3) promoted the progression of CRC whereas its function in peritoneal metastasis was
Tian-Hao Lan +14 more
doaj +2 more sources
Molecular Therapy: Oncolytics, 2022 Cancer-associated fibroblasts (CAFs) in the tumor microenvironment are associated with the establishment and progression of peritoneal metastasis. This study investigated the efficacy of replicative oncolytic adenovirus-mediated p53 gene therapy (OBP-702)
Toshihiro Ogawa +11 more
doaj +2 more sources
Metastasis-associated fibroblasts in peritoneal surface malignancies
British Journal of CancerOver decades, peritoneal surface malignancies (PSMs) have been associated with limited treatment options and poor prognosis. However, advancements in perioperative systemic chemotherapy, cytoreductive surgery (CRS), and hyperthermic intraperitoneal ...
C. Ramos +2 more
semanticscholar +3 more sources
Cancer SciencePeritoneal metastasis, also known as peritoneal dissemination or carcinomatosis, refers to the spread of cancer to the peritoneum that lines the abdominal and pelvic cavities and covers the abdominal organs.
Hideki Yamaguchi, Makoto Miyazaki
semanticscholar +3 more sources