Results 31 to 40 of about 821,529 (204)

The contemporary management of peritoneal metastasis: A journey from the cold past of treatment futility to a warm present and a bright future

Ca, 2022
Peritoneal metastasis (PM) is often regarded as a less frequent pattern of spread; however, collectively across all spectra of primary tumors, the consequences of PM impact a large population of patients annually.
Jason M. Foster, Chunmeng Zhang, S. Rehman, P. Sharma, H. Alexander   +4 more
semanticscholar   +1 more source

The lncRNA BDNF-AS/WDR5/FBXW7 axis mediates ferroptosis in gastric cancer peritoneal metastasis by regulating VDAC3 ubiquitination

International Journal on Biological Sciences, 2022
Ferroptosis is a novel form of cell death that is closely associated with the formation of many tumors. Our study focused on the mechanism by which long noncoding RNAs (lncRNAs) regulate ferroptosis in gastric cancer (GC) peritoneal metastasis (PM).
Guo-wei Huang, Zhenxian Xiang, Haitao Wu, Qiu-ming He, Rongzhang Dou, Zaihuan Lin, Chaogang Yang, Sihao Huang, Jialin Song, Z. Di, Shuyi Wang, B. Xiong   +11 more
semanticscholar   +1 more source

Integration of Genomic Biology Into Therapeutic Strategies of Gastric Cancer Peritoneal Metastasis

Journal of Clinical Oncology, 2022
The peritoneum is a common site of metastasis in advanced gastric cancer (GC). Diagnostic laparoscopy is now routinely performed as part of disease staging, leading to an earlier diagnosis of synchronous peritoneal metastasis (PM). The biology of GCPM is
Y. X. Gwee, D. Chia, Jimmy B. Y. So, W. Ceelen, W. Yong, P. Tan, C. Ong, R. Sundar   +7 more
semanticscholar   +1 more source

Noninvasive Prediction of Occult Peritoneal Metastasis in Gastric Cancer Using Deep Learning

JAMA Network Open, 2021
Key Points Question Can occult peritoneal metastasis be accurately assessed before surgery and without any invasive intervention? Findings In this cohort study of 1978 patients, a deep neural network, the Peritoneal Metastasis Network, was developed for ...
Yuming Jiang, Xiaokun Liang, Wei Wang, Chuanli Chen, Q. Yuan, Xiaodong Zhang, Na Li, Hao Chen, Jiang Yu, Yaoqin Xie, Yikai Xu, Zhiwei Zhou, Guoxin Li, Ruijiang Li   +13 more
semanticscholar   +1 more source

A Case of Peritoneal Dissemination and Splenic Metastasis after Gastric Cancer Surgery That Could Be Controlled with Multidisciplinary Treatment

Case Reports in Oncology, 2020
Splenic metastasis is known to occur at the terminal stage of cancer. While peritoneal dissemination is the most frequent recurrence of gastric cancer, metastasis to the spleen from gastric cancer is very rare. Splenectomy is currently the most effective
Nozomi Karakuchi, Senichiro Yanagawa, Daisuke Takei, Shinya Kodama, Yukio Takeshima, Kazuo Sumimoto   +5 more
doaj   +1 more source

Apolipoprotein C‐II induces EMT to promote gastric cancer peritoneal metastasis via PI3K/AKT/mTOR pathway

Clinical and Translational Medicine, 2021
Background Peritoneal metastasis (PM) occurs frequently in patients with gastric cancer (GC) and confers poor survival. Lipid metabolism acts as a non‐negligible regulator in epithelial–mesenchymal transition (EMT), which is crucial for the metastasis of
Chao Wang, Zhi Yang, En-Shi Xu, Xiaofei Shen, Xingzhou Wang, Zijian Li, Heng Yu, Kai Chen, Qiongyuan Hu, X. Xia, Song Liu, W. Guan   +11 more
semanticscholar   +1 more source

MiR-136 inhibits gastric cancer–specific peritoneal metastasis by targeting HOXC10

Tumor Biology, 2017
Functions of microRNAs have been characterized in the embryologic, physiologic, and oncogenic processes, but the role of microRNAs in mediating tumor-specific organ metastasis was addressed only recently and still absent in gastric cancer peritoneal ...
Jianyong Zheng, Peng Ge, Xiaonan Liu, Jiangpeng Wei, Guosheng Wu, Xiaohua Li   +5 more
doaj   +1 more source

Predicting postoperative peritoneal metastasis in gastric cancer with serosal invasion using a collagen nomogram

Nature Communications, 2021
Accurate prediction of peritoneal metastasis for gastric cancer (GC) with serosal invasion is crucial in clinic. The presence of collagen in the tumour microenvironment affects the metastasis of cancer cells.
Dexin Chen, Zhangyuanzhu Liu, Wenju Liu, Meiting Fu, Wei Jiang, Shuoyu Xu, Guangxing Wang, Feng Chen, Jian-ping Lu, Hao Chen, Xiaoyu Dong, Guoxin Li, Gang Chen, S. Zhuo, Jun Yan   +14 more
semanticscholar   +1 more source

EZH2-H3K27me3 mediated KRT14 upregulation promotes TNBC peritoneal metastasis

bioRxiv, 2021
Triple Negative Breast Cancer (TNBC) is known to have poor prognosis and adverse clinical outcome among all breast cancer subtypes due to the absence of available targeted therapy for it. Emerging literature indicates that epigenetic reprogramming is now
A. Verma, Akhilesh Singh, M. A. Nengroo, K. K. Saini, Abhipsa Sinha, Ashutosh Kumar Singh, D. Datta   +6 more
semanticscholar   +1 more source

Establishment and Characterization of Paired Primary and Peritoneal Seeding Human Colorectal Cancer Cell Lines: Identification of Genes That Mediate Metastatic Potential

Translational Oncology, 2018
Peritoneal metastasis is one of the major patterns of unresectability in colorectal cancer (CRC) and a cause of death in advanced CRC. Identification of distinct gene expressions between primary CRC and peritoneal seeding metastasis is to predict the ...
Soon-Chan Kim, Chang-Won Hong, Sang-Geun Jang, Ye-Ah Kim, Byong-Chul Yoo, Young-Kyoung Shin, Seung-Yong Jeong, Ja-Lok Ku, Jae-Gahb Park   +8 more
doaj   +1 more source