Results 61 to 70 of about 821,529 (204)

Comprehensive Roles and Future Perspectives of Exosomes in Peritoneal Metastasis of Gastric Cancer

Frontiers in Oncology, 2021
Gastric cancer (GC) is one of the most prevalent digestive malignancies. A great number of patients at first visit or post curative resections are diagnosed with widespread metastasis within the peritoneal cavity.
Xiangliu Chen, Haiyong Wang, Yingying Huang, Yanyan Chen, Chuanzhi Chen, Wei Zhuo, Lisong Teng   +6 more
doaj   +1 more source

Macrophages reprogramming improves immunotherapy of IL-33 in peritoneal metastasis of gastric cancer

EMBO Molecular Medicine
Peritoneal metastasis (PM) has a suppressive tumor immune microenvironment (TIME) that limits the effects of immunotherapy. This study aimed to investigate the immunomodulatory effects of intraperitoneal administration of IL-33, a cytokine that is ...
Keying Che, Yuting Luo, Xueru Song, Zhe Yang, Hanbing Wang, Tao Shi, Yue Wang, Xuan Wang, Hongyan Wu, Lixia Yu, Baorui Liu, Jia Wei   +11 more
semanticscholar   +1 more source

Study of SOX combined with intraperitoneal high‐dose paclitaxel in gastric cancer with synchronous peritoneal metastasis: A phase II single‐arm clinical trial

Cancer Medicine, 2022
Intraperitoneal paclitaxel is proved to be efficient for peritoneal metastasis of gastric cancer. It remains uncertain the efficacy and safety of the triplets regimen which combined intraperitoneal high‐dose paclitaxel with systemic SOX in gastric cancer
Lili Tu, Weihan Zhang, Luzina Ni, Zihan Xu, Kun Yang, H. Gou, Qing Zhu, Ming Liu, Yu Yang, Jian-kun Hu, M. Qiu   +10 more
semanticscholar   +1 more source

Differential expression of PD-L1 between primary and metastatic epithelial ovarian cancer and its clinico-pathological correlation

Scientific Reports, 2021
Ovarian cancer (OC) is one of the most common gynecologic cancer, which has the worst prognosis and highest mortality rate. The lack of curative treatment and the high relapse rate, especially in advanced OC, continues to present a clinical challenge ...
Sandeep Kumar Parvathareddy, Abdul K. Siraj, Ismail A. Al-Badawi, Asma Tulbah, Fouad Al-Dayel, Khawla S. Al-Kuraya   +5 more
doaj   +1 more source

Delivery of LINC00589 via mesoporous silica nanoparticles inhibits peritoneal metastasis in gastric cancer.

Cancer Letters, 2022
Peritoneal metastasis is one of the common forms of metastasis in gastric cancer (GC). In this study, we identified the expression pattern of LINC00589 in GC patients and investigate the biological function in GC cells.
Shuchang Wang, Lulu Wo, Zizhen Zhang, Chunchao Zhu, Chaojie Wang, Yangyang Wang, Lechun Hou, H. Cao, Q. Zhao, E. Zhao   +9 more
semanticscholar   +1 more source

LncRNA SPOCD1-AS from ovarian cancer extracellular vesicles remodels mesothelial cells to promote peritoneal metastasis via interacting with G3BP1

Journal of experimental & clinical cancer research : CR, 2021
Background Metastasis is the key cause of death in ovarian cancer patients. To figure out the biological nature of cancer metastasis is essential for developing effective targeted therapy.
Conghui Wang, Jiaying Wang, Xiameng Shen, Mingyue Li, Yongfang Yue, Xiaodong Cheng, Weiguo Lu, Xinyu Wang, Xing Xie   +8 more
semanticscholar   +1 more source

A systematic CRISPR screen reveals an IL-20/IL20RA-mediated immune crosstalk to prevent the ovarian cancer metastasis

eLife, 2021
Transcoelomic spread of cancer cells across the peritoneal cavity occurs in most initially diagnosed ovarian cancer (OC) patients and accounts for most cancer-related death. However, how OC cells interact with peritoneal stromal cells to evade the immune
Jia Li, Xuan Qin, Jie Shi, Xiaoshuang Wang, Tong Li, Mengyao Xu, Xiaosu Chen, Yujia Zhao, Jiahao Han, Yongjun Piao, Wenwen Zhang, Pengpeng Qu, Longlong Wang, Rong Xiang, Yi Shi   +14 more
doaj   +1 more source

Molecular mediators of peritoneal metastasis in pancreatic cancer [PDF]

Cancer and Metastasis Reviews, 2020
AbstractPancreatic cancer is the third leading cause of cancer death in the USA, and pancreatic ductal adenocarcinoma (PDA) constitutes 85% of pancreatic cancer diagnoses. PDA frequently metastasizes to the peritoneum, but effective treatment of peritoneal metastasis remains a clinical challenge. Despite this unmet need, understanding of the biological
Leela Rani Avula, Brendan Hagerty, Christine Alewine   +2 more
openaire   +2 more sources

PEGylated liposome IHL-305 markedly improved the survival of ovarian cancer peritoneal metastasis in mouse

BMC Cancer, 2012
Background Advanced ovarian cancer is characterized by peritoneal metastasis and the accumulation of ascites. Peritoneal metastasis of ovarian cancer is a major cause of the negative treatment outcome, as these metastases are resistant to most ...
Konishi Hiroaki, Takagi Akimitsu, Kurita Akinobu, Kaneda Norimasa, Matsuzaki Takeshi   +4 more
doaj   +1 more source

Development of the Peritoneal Metastasis: A Review of Back-Grounds, Mechanisms, Treatments and Prospects

Journal of Clinical Medicine, 2022
Peritoneal metastasis is a malignant disease which originated from several gastrointestinal and gynecological carcinomas and has been leading to a suffering condition in patients for decades.
Kaijie Ren, Xin Xie, Tianhao Min, Tuanhe Sun, Haonan Wang, Yong Zhang, C. Dang, H. Zhang   +7 more
semanticscholar   +1 more source