Results 121 to 130 of about 45,110 (263)

GCN2 in proteostasis: structural logic, signalling networks and disease

The FEBS Journal, EarlyView.
Threats to protein synthesis activate the kinase GCN2, initiating the integrated stress response (ISR). GCN2 is triggered by stalled ribosomes and uncharged tRNAs, which accumulate when amino acids are scarce. The ISR adjusts cellular physiology by promoting redox balance, protein quality control, and mitochondrial optimisation.
JiaYi Zhu, Stefan J. Marciniak
wiley   +1 more source

Chemical modulation of the unfolded protein response reveals an antiviral role for the PERK pathway in human coronavirus 229E infection. [PDF]

RSC Chem Biol
Pellizzari-Delano IE, Tooley TH, Mondal D, Jani K, Gallardo-Flores CE, Colpitts CC.   +5 more
europepmc   +1 more source

Spatiotemporal dynamics of β‐arrestin‐mediated Src activation in 5‐HT7 receptor signaling pathway

The FEBS Journal, EarlyView.
GPCRs induce distinct cellular responses via G protein‐ or β‐arrestin‐mediated signaling pathways. This study revealed that β‐arrestin‐biased 5‐HT7R ligand induces slow, sustained Src activation, contrasting with transient G protein‐mediated activation.
Hyunbin Kim, Yong Woo Lee, Huimin Lee, Eunseo Park, Jieon Lee, Hae Nim Lee, Kyeong‐Man Kim, Hyunah Choo, Jihye Seong   +8 more
wiley   +1 more source

Genome-wide identification and expression analysis of PERK genes in peanut and revelation of bidirectional immune regulatory function. [PDF]

Front Plant Sci
Peng J, Liu W, Yu J, Fu D, Sun Y, Zheng X, Chen Y, Xia F, Chen J.   +8 more
europepmc   +1 more source

The Role of Index Fund Ownership in the Era of Say‐on‐Pay

Financial Management, EarlyView.
ABSTRACT We examine whether and how index funds influence executive compensation in the post‐Say‐on‐Pay era. Using the annual reconstitution of the Russell indexes as a source of exogenous variation in index fund ownership, we document a causal effect of index ownership on CEO pay structure.
Kiseo Chung, Hwanki Brian Kim
wiley   +1 more source

Agarose oligosaccharides balance intestinal stem cell homeostasis in aging D. melanogaster by regulating the Acetobacter persici-acetic acid-JAK/STAT signaling axis. [PDF]

Microbiome
Fan S, Xu Q, Zhang Q, She J, Zhang C, Christian M, Wang Z, Dai X.   +7 more
europepmc   +1 more source

Organization Capital and Firm Resilience to Cash Flow Shocks

Financial Review, EarlyView.
ABSTRACT Spanning a 3‐year window before and after the COVID‐19 pandemic (2017–2022), this study examines the role of organizational capital in shaping firm resilience to cash flow shocks. We find that organizational capital significantly mitigates adverse cash flow impacts arising from pandemic‐related operational disruptions.
Chen Huang, Georgios P. Kouretas, Tam D. Nguyen, Yu Zhang   +3 more
wiley   +1 more source

Fertility Governance Through Cascaded Accountability: Building Inclusive Safety Nets for Vulnerable Workers

Gender, Work &Organization, EarlyView.
ABSTRACT This article examines how workplace fertility governance operates as a system of control, consent, and inequality shaped by organizational, cultural, and institutional forces. Drawing on feminist theory, we develop a multilevel framework of cascading accountability that integrates symbolic violence, biopolitics, chrononormativity, and ...
Meltem Yavuz Serçekman, Mustafa F. Özbilgin   +1 more
wiley   +1 more source

PERK/ATF4/LAMP3-arm contributes to the aggressive phenotype of hepatocellular carcinoma cells in response to the chronic ethanol exposure. [PDF]

Sci Rep
Goyal H, Kaur J.
europepmc   +1 more source

From inclusion to (neuro)divergent safe space in organizations

International Journal of Management Reviews, EarlyView.
Abstract Neurodiversity in organizations remains an underexplored area, leaving gaps in understanding how organizations may create safe spaces for and with neurodivergent employees. This article engages with current neuro‐inclusion debates and advocates for a shift towards a framework of (neuro)divergent safe space, offering a more refined exploration ...
Frederike Scholz, Amber Kersten, Joanna Maria Szulc   +2 more
wiley   +1 more source