Results 131 to 140 of about 46,487 (267)

Endoplasmic reticulum stress in antitumor immunity and immunotherapy resistance: mechanisms and therapeutic implications. [PDF]

Mol Cancer
Zhao Y, Shang Y, Luan T, Yu Z, Yue Y, Niu X, Li H, Wang S, Wang C, Liu L.   +9 more
europepmc   +1 more source

Visual Cues for Logical Reasoning about Text Enhance Metacognitive Sensitivity

Computer Graphics Forum, EarlyView.
Abstract An important part of critical thinking is analyzing the logical structure of inferences made in text, such as checking whether if–then rules appearing in legal regulations or scientific arguments are applied correctly. Metacognitive sensitivity, defined as feeling confident about one's correct answers and uncertain about incorrect ones, is an ...
A. Schlieder, J. Rummel, F. Sadlo
wiley   +1 more source

Flavivirus-Induced ER Stress and Unfolded Protein Response: A Central Hub Linking Lipid Droplet Remodeling and Viral Replication. [PDF]

Viruses
Muhammad I, Craft K, Pei S, Cruz-Cosme R, Tang Q.   +4 more
europepmc   +1 more source

CKAP4 Regulates ERS‐Induced Apoptosis in Osteoclasts Through FOXO3 in Periodontitis

Cell Proliferation, EarlyView.
CKAP4 promotes the transcription of PERK via FOXO3 in OCs, thereby facilitating ER stress‐induced apoptosis. In periodontitis, the reduction of CKAP4 in OCs leads to decreased OC apoptosis, which exacerbates alveolar bone resorption. ABSTRACT Periodontitis is a prevalent oral disease characterised by chronic inflammation and irreversible alveolar bone ...
Jiayu Cheng, Dihao Tao, Wenzhe Wang, Huiyu Wang, Hanzhe Wang, Yufan Liang, Jia Guo, Wenhao Liu, Yiming Wang, Jianhua Yang, Xiaoning He, Ce Shan, Bei Li   +12 more
wiley   +1 more source

Integrin β3 Promotes Retinal Neovascularization via Endoplasmic Reticulum Stress-Mediated Endothelial Cell Senescence. [PDF]

Invest Ophthalmol Vis Sci
Qian Y, Song Y, Ma J.
europepmc   +1 more source

A Specific tRNA Half, 3'tiRNA‐GlyGCC, Regulates Hypoxic Pulmonary Artery Smooth Muscle Cell Proliferation via Myrf‐Mediated Endoplasmic Reticulum Stress

Cell Proliferation, EarlyView.
A schematic diagram illustrating how 3′tiRNA‐GlyGCC promotes the endoplasmic reticulum stress (ERS) and proliferation in hypoxic pulmonary artery smooth muscle cells (PASMCs) by inhibiting the expression of myelin regulatory factor (Myrf), ultimately leading to pulmonary hypertension (PH).
Lixin Zhang, Xiaoyu Guan, Xiangrui Zhu, Yingying Hao, Ya Xu, Hao Yuan, Danni Gao, Hongxia Du, Jiayu Li, Weiwei Cao, Cui Ma, Xiaoying Wang   +11 more
wiley   +1 more source

Noncanonical role of KDM5C in conferring bortezomib resistance via the PERK‒Nrf2 axis in multiple myeloma. [PDF]

Cell Death Dis
Lu P, Shangguan W, Qian W, Wu D, Li W, Huang J, Xu P, Chen D, Li F, Chen B, Zhao Q.   +10 more
europepmc   +1 more source

The Politics of (E)valuation in Community Projects: Creating a Living Impact Methodology to Pluralize Accountability and Center Lived Experience

Financial Accountability &Management, EarlyView.
ABSTRACT Increasingly, community‐based organizations (CBOs) that have a social impact are required to evidence their impact through accountability and evaluation methods that are complex and inappropriate for their specific context. In response to this challenge, we offer a participatory approach to social return on investment (SROI), which builds on a
Rebecca Warren, Christopher Cunningham, Lewis Smith   +2 more
wiley   +1 more source

Mechanism of paraventricular nucleus H₂S on PERK/TXNIP/NLRP3 pathway in male spontaneously hypertensive rats. [PDF]

Physiol Rep
Liang YF, Chen SY, Wang H, Song HJ, Zhang BC, Wang MF, Lv C, Wang XY, Zhang S, Xing HY, Yuan Q, Li HB, Ding XR, Xing ZR, Han XY, Zhang DD.   +15 more
europepmc   +1 more source

ER proteostasis meets mitochondrial function: contact sites as hubs of communication and therapeutic targets

The FEBS Journal, EarlyView.
Proteostasis ensures proper protein folding, modification, and degradation, while its impairment triggers ER stress. Chronic ER stress and maladaptive UPR via the CHOP–ERO1 axis remodel ERMCs, altering calcium signaling and mitochondrial metabolism.
Giorgia Maria Renna, Alessandro Cherubini, Ersilia Varone, Serena Germani, Alice Marrazza, Ester Zito   +5 more
wiley   +1 more source