Results 141 to 150 of about 59,057 (299)

Tissue Factor‐High Ovarian Clear Cell Carcinoma Shows Immune‐Cold Features and Preclinical Activity of Tisotumab Vedotin

Cancer Science, EarlyView.
F3/TF‐high ovarian clear cell carcinoma exhibits an immune‐cold phenotype characterized by reduced immune‐cell fractions and attenuated cancer‐cell interferon programs, with frequent B7‐H4 co‐expression. Patient‐derived models show preclinical sensitivity to the TF‐directed antibody–drug conjugate tisotumab vedotin.
Yutaro Mori, Ryo Tamura, Kotaro Takahashi, Kaoru Yamawaki, Tatsuya Ishiguro, Teiichi Motoyama, Koji Okamoto, Kosuke Yoshihara   +7 more
wiley   +1 more source

Etomidate Prevents Homocysteine‑Induced Endothelial Dysfunction by Suppressing PERK‑eIF2α‑ATF4 Signaling, Oxidative Stress, Mitochondrial Injury, and Autophagic Dysregulation. [PDF]

J Biochem Mol Toxicol
Song M, Tang H.
europepmc   +1 more source

Genotype‐Informed Whole‐Animal Kinome Screening Reveals Shared Kinase Vulnerabilities Across Driver Contexts in PDAC

Cancer Science, EarlyView.
Overview of experimental workflow and key findings. Clinically prevalent 2‐hit and 3‐hit PDAC genotypes were first modeled in Drosophila to enable kinome‐wide genetic screening. Candidate therapeutic targets were prioritized using human tumor expression data and pathway enrichment analyses.
Han Hai, Takako Ooshio, Hui Jiang, Taku Kimura, Yusuke Satoh, Soichiro Hata, Taiga Hirata, Jiayi Liu, Tongwei Liu, Ryodai Yamamura, Masahiro Sonoshita   +10 more
wiley   +1 more source

The PERK-GADD45A axis is a key driver of hepatic stellate cell activation. [PDF]

Hepatol Commun
Barupala N, Misra J, Bibian E, Baxter R, Singh V, Xique N, Goins ED, Jackson A, Ebert SM, Adams CM, Maiers JL.   +10 more
europepmc   +1 more source

Learning to Evaluate Yourself. The Consequences of Institutionalized Understandings of Progression for Young People With Care Experience

Child &Family Social Work, EarlyView.
ABSTRACT This article examines how young people who have been closely involved with child welfare services throughout their upbringing are required to assess and evaluate their life and progress in institutionalized ways. Within Danish child welfare policy and social work practice, progress is institutionally understood as a linear and one‐dimensional ...
Anne‐Kirstine Mølholt, Tea Torbenfeldt Bengtsson   +1 more
wiley   +1 more source

Visual Cues for Logical Reasoning about Text Enhance Metacognitive Sensitivity

Computer Graphics Forum, EarlyView.
Abstract An important part of critical thinking is analyzing the logical structure of inferences made in text, such as checking whether if–then rules appearing in legal regulations or scientific arguments are applied correctly. Metacognitive sensitivity, defined as feeling confident about one's correct answers and uncertain about incorrect ones, is an ...
A. Schlieder, J. Rummel, F. Sadlo
wiley   +1 more source

Cellular Responses to Flavivirus Infections: Stress Signaling at the Crossroads of Host Defense and Virus Infection. [PDF]

Viruses
Badu P, González ETC, Pager CT.
europepmc   +1 more source

Specialist lives: Yldiz Perk

, 2002
Perk, Y
core   +1 more source

A Specific tRNA Half, 3'tiRNA‐GlyGCC, Regulates Hypoxic Pulmonary Artery Smooth Muscle Cell Proliferation via Myrf‐Mediated Endoplasmic Reticulum Stress

Cell Proliferation, EarlyView.
A schematic diagram illustrating how 3′tiRNA‐GlyGCC promotes the endoplasmic reticulum stress (ERS) and proliferation in hypoxic pulmonary artery smooth muscle cells (PASMCs) by inhibiting the expression of myelin regulatory factor (Myrf), ultimately leading to pulmonary hypertension (PH).
Lixin Zhang, Xiaoyu Guan, Xiangrui Zhu, Yingying Hao, Ya Xu, Hao Yuan, Danni Gao, Hongxia Du, Jiayu Li, Weiwei Cao, Cui Ma, Xiaoying Wang   +11 more
wiley   +1 more source

CRM-1 Aggravates Stroke Injury by Promoting BANF1-Mediated Unfolded Protein Response Through Inducing Nuclear Export of ALKBH5. [PDF]

FASEB J
Liu C, Li C, Hu T, Duan W, Zheng L, Li A.   +5 more
europepmc   +1 more source