Results 161 to 170 of about 59,057 (299)

GCN2 in proteostasis: structural logic, signalling networks and disease

The FEBS Journal, EarlyView.
Threats to protein synthesis activate the kinase GCN2, initiating the integrated stress response (ISR). GCN2 is triggered by stalled ribosomes and uncharged tRNAs, which accumulate when amino acids are scarce. The ISR adjusts cellular physiology by promoting redox balance, protein quality control, and mitochondrial optimisation.
JiaYi Zhu, Stefan J. Marciniak
wiley   +1 more source

Combined Time-Restricted Feeding and Physical Exercise Attenuate ER Stress and Improve Liver Inflammation and Collagen Deposition in Aged Mice. [PDF]

Cell Biochem Funct
Antonio GCF, Pitoli BS, Macêdo APA, de Lima RD, Muñoz VR, Vieira RFL, Dias LM, Cintra DE, Silva ASRD, Ropelle ER, Pauli JR.   +10 more
europepmc   +1 more source

Biogenesis of TNF‐α‐insights into proteostasis and inflammation

The FEBS Journal, EarlyView.
TNF‐α biogenesis, trafficking, and signalling are tightly and reciprocally coupled to cellular proteostasis systems, including ER chaperones and endoplasmic reticulum‐associated degradation. This bidirectional crosstalk determines whether TNF‐α responses are adaptive or proteotoxic.
Bailasan Haidar, Céline Philippe, Eric Chevet, Jiří Zahradník   +3 more
wiley   +1 more source

PERK Is Dispensable for Smooth Muscle Cell Phenotype Switching in Atherosclerosis. [PDF]

Arterioscler Thromb Vasc Biol
Zhu LY, Xue C, Bashore AC, Cui J, Yao S, Sachs N, Wettich JL, Coronel J, Garcia EJ, Khalid S, Saleheen D, Li M, Maegdefessel L, Reilly MP.   +13 more
europepmc   +1 more source

Iloperidone treatment mitigates the Juvenile Huntington's Disease phenotype possibly via Sigma‐1 Receptor Modulation

The FEBS Journal, EarlyView.
We investigated the potential of iloperidone as an activator of Sigma‐1 receptor (S1R) neuroprotective function in juvenile Huntington's disease (jHD). We tested iloperidone on cortical neurons differentiated from patient‐derived iPSCs, demonstrating that it acts as a S1R agonist, decreasing apoptosis, huntingtin aggregation, and oxidative stress ...
Ersilia Fornetti, Gaia Galluzzi, Mario Frezzini, Cécile Exertier, Vittorio Brufani, Gianni Colotti, Giancarlo Ruocco, Jessica Rosati, Angelo Luigi Vescovi, Daniele Narzi, Ilaria Genovese, Andrea Ilari   +11 more
wiley   +1 more source

Endoplasmic reticulum stress in steroid-induced osteonecrosis: translational bottlenecks and targeted therapeutic strategies. [PDF]

Front Pharmacol
Liu T, Shen Y, Wang W, Fu F, Yuan M, Huang J, Xu H, He Y, Jia H, Wang J, Wei X, Zhang H, Gao X, Tang D.   +13 more
europepmc   +1 more source

Wilfred Perks [PDF]

Journal of the Institute of Actuaries, 1970
openaire   +1 more source

Ubiquitin and ubiquitin‐like modifications in the endoplasmic reticulum stress response

The FEBS Journal, EarlyView.
Endoplasmic reticulum (ER) stress activates various proteostasis control processes, including the unfolded protein response, ribosome‐associated quality control, and ER‐associated degradation. Ubiquitin and ubiquitin‐like modifications dynamically regulate these processes to determine cell fate, promoting adaptation or inducing cell death.
Tony Avril, Matthieu Le Gallo, Elodie Lafont   +2 more
wiley   +1 more source

Extracts of <i>Aspidopterys tomentosa</i> Attenuate Nephrolithiasis via Inhibiting Endoplasmic Reticulum Stress. [PDF]

Pharmaceuticals (Basel)
Liu S, Li M, Yu J, Yin C, Li S, Deng Z, Yuan Y, Shi X, Tang D, Li Y, Chen X.   +10 more
europepmc   +1 more source

Dual IRE1 targets: Determinants of the cell fate?

The FEBS Journal, EarlyView.
IRE1 is an ER stress sensor that restores protein homeostasis through two signaling activities: XBP1s, which upregulates its target gene expression or RIDD which downregulates its target transcripts. We recently identified Dual IRE1 Targets (DIT) which are modulated by both XBP1s and RIDD activities.
Eva Billat, Léane Legrand, Tony Avril, Elodie Lafont   +3 more
wiley   +1 more source