Results 151 to 160 of about 46,487 (267)

Endoplasmic reticulum stress in disease pathogenesis: its implications for therapy. [PDF]

Signal Transduct Target Ther
Wei S, Zhang N, Zhang H, Chen Z, Li S, Wu W, Liu Z, Xia Z, Luo P, Cheng Q.   +9 more
europepmc   +1 more source

Iloperidone treatment mitigates the Juvenile Huntington's Disease phenotype possibly via Sigma‐1 Receptor Modulation

The FEBS Journal, EarlyView.
We investigated the potential of iloperidone as an activator of Sigma‐1 receptor (S1R) neuroprotective function in juvenile Huntington's disease (jHD). We tested iloperidone on cortical neurons differentiated from patient‐derived iPSCs, demonstrating that it acts as a S1R agonist, decreasing apoptosis, huntingtin aggregation, and oxidative stress ...
Ersilia Fornetti, Gaia Galluzzi, Mario Frezzini, Cécile Exertier, Vittorio Brufani, Gianni Colotti, Giancarlo Ruocco, Jessica Rosati, Angelo Luigi Vescovi, Daniele Narzi, Ilaria Genovese, Andrea Ilari   +11 more
wiley   +1 more source

Cigarette Smoke Induces Canonical Stress Granule Formation in Human Bronchial Epithelial Cells in Reactive Oxygen Species- and PERK-Dependent Manners. [PDF]

Biomolecules
Bhowmik M, Zheng C, Bekele B, Failler J, Klatt C, Farimani S, Jones B, Tyan CC, Abu-Arish A.   +8 more
europepmc   +1 more source

Perk Up

Ophthalmology, 1985
openaire   +1 more source

Ubiquitin and ubiquitin‐like modifications in the endoplasmic reticulum stress response

The FEBS Journal, EarlyView.
Endoplasmic reticulum (ER) stress activates various proteostasis control processes, including the unfolded protein response, ribosome‐associated quality control, and ER‐associated degradation. Ubiquitin and ubiquitin‐like modifications dynamically regulate these processes to determine cell fate, promoting adaptation or inducing cell death.
Tony Avril, Matthieu Le Gallo, Elodie Lafont   +2 more
wiley   +1 more source

Crosstalk between endoplasmic reticulum stress and mitochondrial homeostasis: A new perspective on ophthalmic disease treatment. [PDF]

J Cell Commun Signal
Jiang L, Cuomu G, Jijia S, Yang Y, Liu J, Tao Y.   +5 more
europepmc   +1 more source

Dual IRE1 targets: Determinants of the cell fate?

The FEBS Journal, EarlyView.
IRE1 is an ER stress sensor that restores protein homeostasis through two signaling activities: XBP1s, which upregulates its target gene expression or RIDD which downregulates its target transcripts. We recently identified Dual IRE1 Targets (DIT) which are modulated by both XBP1s and RIDD activities.
Eva Billat, Léane Legrand, Tony Avril, Elodie Lafont   +3 more
wiley   +1 more source

Unfolded protein response in bronchopulmonary dysplasia: mechanisms, pathways, and therapeutic implications. [PDF]

Front Cell Dev Biol
Yu H, Guo Y, Wang X, Guo W, Zhang Y.
europepmc   +1 more source

The Role of Index Fund Ownership in the Era of Say‐on‐Pay

Financial Management, EarlyView.
ABSTRACT We examine whether and how index funds influence executive compensation in the post‐Say‐on‐Pay era. Using the annual reconstitution of the Russell indexes as a source of exogenous variation in index fund ownership, we document a causal effect of index ownership on CEO pay structure.
Kiseo Chung, Hwanki Brian Kim
wiley   +1 more source

LIFe of the sugar-free party in cancer metabolism. [PDF]

Trends Endocrinol Metab
Tighanimine K, Manning BD.
europepmc   +1 more source