Results 181 to 190 of about 45,110 (263)

Reactive oxygen species in fetal growth restriction mechanisms and therapeutic directions (Review). [PDF]

Int J Mol Med
Cheng D, Yang S, Wang C, Fan K, Gao F, Sun Q.   +5 more
europepmc   +1 more source

Projected Warming of the Southern Ocean Disrupts Embryonic Development and Hatch Timing in Antarctic Fish

Global Change Biology Communications, Volume 1, Issue 1, March 2026.
Embryos are particularly sensitive to thermal challenge. Antarctic fish embryos raised at projected Southern Ocean temperatures hatch during the winter, have a high incidence of morphological abnormalities, have shorter body lengths, and express genes indicative of cellular stress.
Margaret Streeter, Nathalie R. Le François, Thomas Desvignes, Jacob Grondin, John H. Postlethwait, H. William Detrich III, Jacob M. Daane   +6 more
wiley   +1 more source

Endoplasmic reticulum stress-mediated programmed cell death in the tumor microenvironment. [PDF]

Cell Death Discov
Chai H, Hu Q, Yao S, Ma S, Su W.
europepmc   +1 more source

Global Burden of Lead Exposure: Integrating Epidemiology, Molecular Mechanisms, and Mitigation Approaches

Health Science Reports, Volume 9, Issue 3, March 2026.
ABSTRACT Background Lead is a nonessential, toxic heavy metal that causes widespread environmental contamination, affecting humans, animals, plants, and ecosystems. Globally, an estimated 800 million children have blood lead levels (BLLs) above 5 µg/dL.
Gudisa Bereda
wiley   +1 more source

Mannose metabolic pathway senses glucose supply and regulates cell fate decisions. [PDF]

J Biol Chem
Wang Z, Miyamoto Y, Suzuki T, Tanaka-Okamoto M, Mizote Y, Dohmae N, Tahara H, Taniguchi N, Harada Y.   +8 more
europepmc   +1 more source

Comprehensive assessment of unfolded protein response and its association with tumor progression in pan‐cancer

iMetaOmics, Volume 3, Issue 1, March 2026.
Schematic of the study design. In this study, we developed a comprehensive unfolded protein response (UPR) gene signature and applied it to systematically characterize the UPR landscape across multiple cancer types. By integrating bulk and single‐cell transcriptomic data, we revealed substantial inter‐ and intra‐tumoral heterogeneity in UPR activity ...
Xinyu Yang, Faming Zhao, Jing Yang, Xinran Xia, Liwei Chen, Peng Zeng, Liang Chen, Yanxia Hu, Xia Sheng   +8 more
wiley   +1 more source

Propofol attenuates angiogenesis by activating endoplasmic reticulum stress to suppress TFAP2C-driven VEGFA transcription. [PDF]

Apoptosis
Yang F, Liu Y, Li H, Shang X, Hua Q, Zhu Y, Tao B, Sun Z.   +7 more
europepmc   +1 more source

Targeting GRP78 and the Proteostasis Network to Break the Therapeutic Ceiling in Neuroendocrine Prostate Cancer

iNew Medicine, Volume 2, Issue 1, March 2026.
ABSTRACT HSPA5 (also known as GRP78/BiP) is a master regulator of the endoplasmic reticulum (ER) stress response and a key node in the proteostasis network. In neuroendocrine prostate cancer (NEPC), an aggressive, therapy‐refractory lineage that emerges under pressure from androgen receptor (AR) directed therapies, GRP78 is upregulated and co‐opted to ...
Amos Olalekan Akinyemi, Md Rakibul Alam, Mithu Howlader, Mohammad Esfini Farahani, Lixiang Gu, Chun Li, Chripus Ngule, Kevin Fulp, Bolaji Owoyemi, Xinyi Wang, Samuel Nwadialo, Fatemeh Selani, Makumba Esoe, Obaleye Oluwafunminiyi, Zhiguo Li   +14 more
wiley   +1 more source

Astrocytic PERK Deficiency Drives Prefrontal Circuit Dysfunction and Depressive-Like Behaviors. [PDF]

Adv Sci (Weinh)
Chen K, Gupta R, Morizawa YM, Qin Y, Du X, Pang C, Al-Dalahmah O, Dupont MB, Yang G.   +8 more
europepmc   +1 more source

Ginsenoside Rb1 Targets the HRD1‐STING Axis to Mitigate Cholesterol‐Induced VSMC Senescence

Journal of Clinical Laboratory Analysis, Volume 40, Issue 5, March 2026.
Schematic representation of the proposed mechanism of action for Ginsenoside Rb1. Suppression of HRD1 expression in VSMCs cholesterol stimulation, leading to ER stress (BiP/XBP1s upregulation), STING pathway activation, ROS accumulation (including mitochondrial ROS), and ultimately, VSMC senescence.
Haiming Niu, Yingzhang Cai, Conghui Yu, Ning Lin, Miaolian Chen, Linli Wang   +5 more
wiley   +1 more source