Results 81 to 90 of about 45,110 (263)

Polysulfide and persulfide-mediated activation of the PERK-eIF2α-ATF4 pathway increases Sestrin2 expression and reduces methylglyoxal toxicity

Redox Biology
Unfolded protein response (UPR) is activated in cells under endoplasmic reticulum (ER) stress. One sensor protein involved in this response is PERK, which is activated through its redox-dependent oligomerization.
Shin Koike, Hideo Kimura, Yuki Ogasawara
doaj   +1 more source

The Canary Down the Coalmine: Dagenham, London and Labour Politics

The Political Quarterly, EarlyView.
Abstract The history of Dagenham offers unique insights into both the changing composition of the working class and the forces that have reshaped domestic politics throughout the last 100 years, particularly the politics of the British labour movement.
Jon Cruddas
wiley   +1 more source

Autopsy, deathways, and intercultural healthcare in the southern Peruvian Andes Autopsie, pratiques mortuaires et soins de santé interculturels dans le sud des Andes péruviennes

Journal of the Royal Anthropological Institute, EarlyView.
While death remains a popular topic for anthropology, relatively few ethnographic accounts consider the modern bureaucratic processes accompanying it. One such process is public health autopsy, which scholars have largely taken for granted. Existing analysis has regarded it as a form of ‘cultural brokering’ and autopsy reluctance in communities is seen,
David M.R. Orr
wiley   +1 more source

Endoplasmic reticulum stress sensor protein PERK in hepatic stellate cells promotes the progression of hepatocellular carcinoma via p38δ MAPK/IL-1β axis

Scientific Reports
Palmitic acid (PA) absorption from the intestine is increased in metabolic dysfunction-associated steatohepatitis (MASH). It induces endoplasmic reticulum (ER) stress and interleukin-1 beta (IL-1β) production in hepatic stellate cells (HSCs).
Makoto Morita, Yoshio Tokumoto, Takao Watanabe, Yusuke Imai, Atsushi Yukimoto, Toyoki Shimamoto, Ryo Yano, Yuki Okazaki, Yoshiko Nakamura, Osamu Yoshida, Teruki Miyake, Masashi Hirooka, Masanori Abe, Yoichi Hiasa   +13 more
doaj   +1 more source

Human umbilical cord mesenchymal stem cell -derived exosomes alleviated the toxic effects induced by lead on HK-2 cells via regulating the unfolded protein response

Ecotoxicology and Environmental Safety
Lead is an important heavy metal material and also an omnipresent environmental pollutant, which poses extensive hazards to human health, including its nephrotoxicity.
Jiayi He, Zuqing Hu, Zhenjie Gao, Renyi Liu, Zhujun Kang, Shuyi Lan, Yang Wang, Shanshan He, Hongyi Xian, Fatoumata Diallo, Yunxia Jiang, Jiguo Wu, Suli Huang, Ziquan Lv, Dalin Hu   +14 more
doaj   +1 more source

Yoruba Histories of Marriage and Belonging: Gender, Power and Innovation in Eighteenth‐Century West Africa

Gender &History, EarlyView.
ABSTRACT This article argues that marriage was central to historical change in the Yoruba‐speaking region of West Africa during the eighteenth century. It draws on ìtàn, a distinct oral source, to show that conjugality shaped Yoruba processes of urbanisation and political centralisation, gendered divisions of labour and social innovation and creativity.
Insa Nolte
wiley   +1 more source

HYPERSCALING HOUSING: Venture Capital, Real Estate Start‐Ups and the Race to Build a Global Residential Brand

International Journal of Urban and Regional Research, EarlyView.
Abstract What happens when venture capitalists try to reinvent housing in their own image? Synonymous with the rise of Big Tech, venture capitalists (VCs) are asset managers that invest in early‐stage companies, pursuing aggressive growth and market domination. Since the 2008 financial crisis, VCs have poured huge sums into real estate start‐ups.
Tim White
wiley   +1 more source

PERK modulation, with GSK2606414, Sephin1 or salubrinal, failed to produce therapeutic benefits in the SOD1G93A mouse model of ALS.

PLoS ONE
Amyotrophic lateral sclerosis (ALS) has been linked to overactivity of the protein kinase RNA-like ER kinase (PERK) branch of the unfolded protein response (UPR) pathway, both in ALS patients and mouse models.
Fernando G Vieira, Valerie R Tassinari, Joshua D Kidd, Andrew Moreno, Kenneth Thompson, Steven Perrin, Alan Gill, Theo Hatzipetros   +7 more
doaj   +1 more source

Aggregated Compensation Peer Group Disclosure and Managerial Labor Market Competition: A Network Analysis

Journal of Accounting Research, EarlyView.
ABSTRACT In this paper, we develop novel measures of managerial labor market classification and competition by constructing networks of compensation benchmarking peers disclosed in proxy statements. These networks represent firms’ relative positions within the managerial labor market.
RAY RUI GAO, YIFEI LU
wiley   +1 more source

Serial maternal filicide as evidence of Munchausen syndrome by proxy

Journal of Forensic Sciences, EarlyView.
Abstract Munchausen Syndrome by Proxy (MSBP), or Fabricated or Induced Illness (FII), is a form of physical and emotional child abuse and maltreatment that remains frequently under‐detected due to a significant lack of clinical awareness. This case report aims to highlight the challenges of diagnosing MSBP, its impact on victims, and the ethical ...
Ahlem Mtiraoui, Oussama Ajmi, Asma Allaya, Amel Braham, Jaafar Nakhli   +4 more
wiley   +1 more source