Results 71 to 80 of about 2,782,679 (244)

Impaired flickering of the permeability transition pore causes SPG7 spastic paraplegia

EBioMedicine, 2020
Background: Mutations of the mitochondrial protein paraplegin cause hereditary spastic paraplegia type 7 (SPG7), a so-far untreatable degenerative disease of the upper motoneuron with still undefined pathomechanism.The intermittent mitochondrial ...
Irene Sambri, Filomena Massa, Francesca Gullo, Simone Meneghini, Laura Cassina, Michela Carraro, Giorgia Dina, Angelo Quattrini, Lorenzo Patanella, Annamaria Carissimo, Antonella Iuliano, Filippo Santorelli, Franca Codazzi, Fabio Grohovaz, Paolo Bernardi, Andrea Becchetti, Giorgio Casari   +16 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Menadione-induced apoptosis: Roles of cytosolic Ca2+ elevations and the mitochondrial permeability transition pore

, 2002
In normal pancreatic acinar cells, the oxidant menadione evokes repetitive cytosolic Ca(2+) spikes, partial mitochondrial depolarisation, cytochrome c release and apoptosis.
Petersen, Ole Holger, Tepikin, Alexei, Palejwala, Altaf, Watson, Alistair J. M., Gerasimenko, Julia Vladimirovna, Gerasimenko, Oleg Vsevolodovich   +5 more
core   +5 more sources

Pore structure characteristics of deep Upper Paleozoic coal measure tight sandstone reservoirs in northeast Qinshui Basin and its reservoir geological significance

Meitan kexue jishu
Reservoir pore structure is a key factor affecting oil and gas productivity. Accurately characterizing the microscopic pore structure of tight sandstone reservoirs is very important for oil and gas exploration and development. The deep coal measure tight
Fengjie CHEN, Xiaodong ZHANG, Runbin LIU, Shuo ZHANG, Zhiwei ZHAI   +4 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Predicting gas–water permeability in hydrate-bearing sediments considering hydrate morphology

Journal of Rock Mechanics and Geotechnical Engineering
Permeability is a key parameter controlling fluid flow in hydrate reservoirs and plays a critical role in determining gas production capacity and exploitation efficiency.
Jianwei Li, Yu Zhang, Zaobao Liu, Zheng Nie, Yalin Luan   +4 more
doaj   +1 more source

Physiopathology of the Permeability Transition Pore: Molecular Mechanisms in Human Pathology

Biomolecules, 2020
Mitochondrial permeability transition (MPT) is the sudden loss in the permeability of the inner mitochondrial membrane (IMM) to low-molecular-weight solutes.
Massimo Bonora, Simone Patergnani, Daniela Ramaccini, Giampaolo Morciano, Gaia Pedriali, Asrat Endrias Kahsay, Esmaa Bouhamida, Carlotta Giorgi, Mariusz R. Wieckowski, Paolo Pinton   +9 more
doaj   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

On the Voltage Dependence of the Mitochondrial Permeability Transition Pore. A Critical Appraisal.

, 1997
The mitochondrial permeability transition pore, a cyclosporin A-sensitive channel, can be opened by the addition of protonophoric uncouplers such as carbonyl cyanide p-trifluoromethoxyphenylhydrazone (FCCP) after energy-dependent accumulation of Ca2+. We
BERNARDI, PAOLO, PETRONILLI V, SCORRANO, LUCA, Bernardi P, Scorrano L, Valeria Petronilli, Luca Scorrano, Paolo Bernardi   +7 more
core   +1 more source

Identifying the components of the elusive mitochondrial permeability transition pore [PDF]

Proceedings of the National Academy of Sciences, 2014
The mitochondrial permeability transition pore (MPTP) describes an inducible activity that regulates solute exchange between mitochondrial matrix contents and the surrounding cytoplasm, which acutely leads to loss of mitochondrial inner membrane potential but eventually organelle swelling and rupture.
Jason, Karch, Jeffery D, Molkentin
openaire   +2 more sources