Results 51 to 60 of about 2,782,679 (244)
Role of the Mitochondrial Permeability Transition Pore in Apoptosis
Bioscience Reports, 1997 Mitochondrial permeability transition (PT) involves the formation of proteaceous, regulated pores, probably by apposition of inner and outer mitochondrial membrane proteins which cooperate to form the mitochondrial megachannel (=mitochondrial PT pore).
T, Hirsch, I, Marzo, G, Kroemer
openaire +2 more sources
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Relating pore fabric geometry to acoustic and permeability anisotropy in Crab Orchard Sandstone: A laboratory study using magnetic ferrofluid [PDF]
, 2003 Pore fabric anisotropy is a common feature of many sedimentary rocks. In this paper we report results from a comparative study on the anisotropy of a porous sandstone (Crab Orchard) using anisotropy of magnetic susceptibility (AMS), acoustic wave ...
Benson, PM, Platzman, ES, Meredith, PG
core
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Journal of Petroleum Exploration and Production Technology, 2018 Transition zones in tight heterogeneous carbonate reservoirs contain a considerable amount of original oil in place. Identifying and characterizing the petrophysical flow units of the transition zone is crucial for reserve estimation and performance ...
Dai Fu, Hadi Belhaj, Achinta Bera
doaj +1 more source
Frontiers in Immunology, 2023 BackgroundCompared to healthy controls, severe COVID19 patients display increased levels of activated NLRP3-inflammasome (NLRP3-I) and interleukin (IL)-1β. SARS-CoV-2 encodes viroporin proteins E and Orf3a(2-E+2-3a) with homologs to SARS-CoV-1, 1-E+1-3a,
Joseph W. Guarnieri +9 more
doaj +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Meikuang AnquanAiming at the technical problem of low permeability during coal seam gas extraction in Hujiahe Coal Mine, an permeability enhancement method coupling hydraulic fracturing and ultrasonic excitation is proposed.
Guojun Xi +8 more
doaj +1 more source
Journal of Natural Gas Geoscience, 2017 The gas flow in shale nanopores undergoes a transition from continuum-transition flow regimes to Knudsen diffusion, rather than the traditional Darcy flow, due to the dynamic properties of shale gas.
Yunfeng Yang, Fang Bao
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FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source