Results 41 to 50 of about 2,782,679 (244)

Regulation and pharmacology of the mitochondrial permeability transition pore [PDF]

Cardiovascular Research, 2009
The 'mitochondrial permeability transition', characterized by a sudden induced change of the inner mitochondrial membrane permeability for water as well as for small substances (
Dmitry B, Zorov, Magdalena, Juhaszova, Yael, Yaniv, H Bradley, Nuss, Su, Wang, Steven J, Sollott   +5 more
openaire   +2 more sources

The Haves and Have-Nots: The Mitochondrial Permeability Transition Pore across Species

Cells, 2023
The demonstration that F1FO (F)-ATP synthase and adenine nucleotide translocase (ANT) can form Ca2+-activated, high-conductance channels in the inner membrane of mitochondria from a variety of eukaryotes led to renewed interest in the permeability ...
Elena Frigo, Ludovica Tommasin, Giovanna Lippe, Michela Carraro, Paolo Bernardi   +4 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Transient mitochondrial permeability transition pore opening mediates preconditioning-induced protection [PDF]

, 2004
Background - Transient (low-conductance) opening of the mitochondrial permeability transition pore (mPTP) may limit mitochondrial calcium load and mediate mitochondrial reactive oxygen species (ROS) signaling.
Wynne, A, Duchen, M, Yellon, D, Hausenloy, D   +3 more
core  

Aging Enhances the Activation of the Permeability Transition Pore in Mitochondria [PDF]

The Scientific World Journal, 2001
Aging is associated with mitochondrial dysfunction in several tissues. However, it is not known how the observed mitochondrial dysfunction is related to aging-associated tissue degeneration. We have shown previously that the activation of the permeability transition pore (PTP), which is believed to play a critical role in cell necrosis and apoptosis ...
Hagai Rottenberg, Michael Mather
doaj   +5 more sources

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Mitochondrial permeability transition, F1FO-ATPase and calcium: An enigmatic triangle [PDF]

, 2017
In response to calcium mitochondria can undergo a permeability transition—a sudden increase of the permeability of the inner mitochondrial membrane to ions and solutes resulting in cell death.
Salvatore Nesci, NESCI, SALVATORE
core   +1 more source

Axonal Degeneration Is Mediated by the Mitochondrial Permeability Transition Pore [PDF]

The Journal of Neuroscience, 2011
Axonal degeneration is an active process that has been associated with neurodegenerative conditions triggered by mechanical, metabolic, infectious, toxic, hereditary and inflammatory stimuli. This degenerative process can cause permanent loss of function, so it represents a focus for neuroprotective strategies. Several signaling pathways are implicated
Barrientos, Sebastián A., Martínez, Nicolas W., Yoo, Soonmoon, Jara, Juan S., Zamorano, Sebastián, Hetz Flores, Claudio, Twiss, Jeffery L., Alvarez, Jaime, Court, Felipe A.   +8 more
openaire   +9 more sources

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Pore structure characterization of low permeability rocks [PDF]

, 2014
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro Tecnológico, Programa de Pós-Graduação em Ciência e Engenharia de Materiais, Florianópolis, 2014.Hoje as pesquisas em rochas de baixa permeabilidade (grande tendência no mundo e em breve ...
Schmitt, Mayka
core