Results 21 to 30 of about 2,782,679 (244)

Mitochondrial Ca2+ and regulation of the permeability transition pore [PDF]

Journal of Bioenergetics and Biomembranes, 2016
The mitochondrial permeability transition pore was originally described in the 1970's as a Ca2+ activated pore and has since been attributed to the pathogenesis of many diseases. Here we evaluate how each of the current models of the pore complex fit to what is known about how Ca2+ regulates the pore, and any insight that provides into the molecular ...
Stephen, Hurst, Jan, Hoek, Shey-Shing, Sheu   +2 more
openaire   +2 more sources

Methanol extract and fraction of Anchomanes difformis root tuber modulate liver mitochondrial membrane permeability transition pore opening in rats [PDF]

Avicenna Journal of Phytomedicine, 2020
Objective: Extracts of Anchomanes difformis (AD) are used in folkloric medicine to treat several diseases and infections. However, their roles in mitochondrial permeability transition pore opening are not known.
Oludele Olanlokun, Kemi Oloke, Olufunso Olorunsogo   +2 more
doaj   +1 more source

Cohesiveness tunes assembly and morphology of FG nucleoporin domain meshworks – Implications for nuclear pore permeability [PDF]

, 2013
Nuclear pore complexes control the exchange of macromolecules between the cytoplasm and the nucleus. A selective permeability barrier that arises from a supramolecular assembly of intrinsically unfolded nucleoporin domains rich in phenylalanine-glycine ...
Frey, S., Frey, Steffen, Görlich, D., Eisele, N., Richter, R., Steffen Frey, Dirk Görlich, Richter , R., Labokha, A., Ralf P. Richter, Aksana A. Labokha, Görlich, Dirk, Nico B. Eisele, Goerlich, D., Labokha, Aksana a., Eisele, Nico b., Richter, Ralf p.   +16 more
core   +1 more source

Physiological roles of the mitochondrial permeability transition pore [PDF]

Journal of Bioenergetics and Biomembranes, 2016
Neurons experience high metabolic demand during such processes as synaptic vesicle recycling, membrane potential maintenance and Ca2+ exchange/extrusion. The energy needs of these events are met in large part by mitochondrial production of ATP through the process of oxidative phosphorylation.
Nelli, Mnatsakanyan, Gisela, Beutner, George A, Porter, Kambiz N, Alavian, Elizabeth A, Jonas   +4 more
openaire   +2 more sources

Loading rate dependence of permeability evolution in porous aeolian sandstones [PDF]

, 2004
Mechanical properties of rocks are characterized by their notable dependence on the applied deformation rate. However, little is known about the strain rate dependence of fluid flow properties since most laboratory tests are conducted using a single ...
Ira O. Ojala, Ian G. Main, Main, Ian G, Bryne T. Ngwenya, Ojala, Ira O, Ojala, I. O., Ngwenya, B. T., Main, I. G.; id_orcid, Ngwenya, Bryne T   +8 more
core   +1 more source

Permeability-Controlled Probe for Directly Visualizing the Opening of Mitochondrial Permeability Transition Pore in Native Status

, 2022
The opening of mitochondrial permeability transition pore (mPTP) plays a fundamental role in cell apoptosis regulation, ischemia–reperfusion injury, and neurodegenerative disorders.
Weiying Lin (1670665), Baoli Dong (1904452), Weiying Lin, Minggang Tian (1460887), Baoli Dong, Junling Yin, Minggang Tian, Zheming Zhang, Zheming Zhang (1308723), Junling Yin (6864746)   +9 more
core   +1 more source

Permeability and dynamic elastic moduli of controlled porosity ultra-precision aerostatic structures [PDF]

, 2014
Porous ceramic aerostatic bearings enable precise and smooth motion and improved stiffness compared with widely used orifice restrictor bearings. However, the processing techniques so far used are too complex or rely in lowering the sintering temperature
Corbett, John, Durazo-Cardenas, Isidro, Stephenson, David J.   +2 more
core   +1 more source

Mitochondrial targeting of cyclosporin A enables selective inhibition of cyclophilin-D and enhanced cytoprotection after glucose and oxygen deprivation [PDF]

, 2009
CsA (cyclosporin A) is a hydrophobic undecapeptide that inhibits CyPs (cyclophilins), a family of PPIases (peptidylprolyl cis–trans isomerases). In some experimental models, CsA offers partial protection against lethal cell injury brought about by ...
Crompton, M., Henry Dube, Malouitre, S., Sylvanie Malouitre, Selwood, D., Martin Crompton, Dube, H., David Selwood   +7 more
core   +1 more source

Toxic Effects of Unripe Carica papaya (Linn) Fruit Extract on Healthy Rat Liver Mitochondria

Traditional and Integrative Medicine, 2021
The opening of the mitochondrial Permeability Transition (mPT) pore proceeds the activation of programmed cell death (apoptosis) and its functional status serves as marker of mitochondrial health.
Olubukola T Oyebode, Adeola O Olowofolahan, Olufunso O Olorunsogo   +2 more
doaj   +1 more source

Investigations on the relationship among the porosity, permeability and pore throat size of transition zone samples in carbonate reservoirs using multiple regression analysis, artificial neural network and adaptive neuro-fuzzy interface system

Petroleum Research, 2021
Finding an accurate method for estimating permeability aside from well logs has been a difficult task for many years. The most commonly used methods targeted towards regression technique to understand the correlation between pore throat radii, porosity ...
Jamiu Oyekan Adegbite, Hadi Belhaj, Achinta Bera   +2 more
doaj   +1 more source