Results 11 to 20 of about 2,782,679 (244)
The mitochondrial permeability transition pore: A mystery solved? [PDF]
Frontiers in Physiology, 2013 The permeability transition denotes an increase of the mitochondrial inner membrane permeability to solutes with molecular masses up to about 1,500 Da. It is presumed to be mediated by opening of a channel, the permeability transition pore (PTP), whose ...
Paolo eBernardi, Paolo eBernardi
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Regulation of mitochondrial permeability transition pore by PINK1 [PDF]
Molecular Neurodegeneration, 2012 Background Loss-of-function mutations in PTEN-induced kinase 1 (PINK1) have been linked to familial Parkinson’s disease, but the underlying pathogenic mechanism remains unclear.
Gautier Clement A +7 more
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Edaravone, a Radical Scavenger, Inhibits Mitochondrial Permeability Transition Pore in Rat Brain
Journal of Pharmacological Sciences, 2007 Edaravone, a radical scavenger, prevents ischemia/reperfusion injury in the brain, but the detailed mechanism is not known. This study examines the effect of edaravone on mitochondrial permeability transition pore (PTP) in rat brain.
Yuko Takayasu +6 more
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The mitochondrial permeability transition pore components [PDF]
, 2010 The mitochondrial permeability transition pore (MPTP) is a non-specific channel in the inner mitochondrial membrane (IMM) that opens following ischaemia and reperfusion due to the presence of various stimuli, such as oxidative stress, elevated phosphate ...
Mohar, Zoltan
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Mitochondrial permeability transition pore and postconditioning [PDF]
Cardiovascular Research, 2006 Postconditioning has recently been described as a powerful cardioprotection that prevents lethal reperfusion injury. Growing evidence suggests that mitochondrial permeability transition may be a key event in postconditioning. This proposition arises from the complementary observations that: (1) conditions for the mitochondrial permeability transition ...
Odile, Gateau-Roesch +2 more
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Signal transduction to the permeability transition pore [PDF]
FEBS Letters, 2010 The permeability transition pore (PTP) is an inner mitochondrial membrane channel that has been thoroughly characterized functionally, yet remains an elusive molecular entity. The best characterized PTP‐regulatory component, cyclophilin (CyP) D, is a matrix protein that favors pore opening.
RASOLA, ANDREA +3 more
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Physiological Roles of the Permeability Transition Pore [PDF]
Circulation Research, 2012 Mitochondria are implicated in many important cellular functions covering the whole life cycle from mitochondrial biogenesis to cell death. Mitochondrial homeostasis is tightly regulated, and mitochondrial dysfunction is frequently associated with severe human pathologies (eg, cardiovascular diseases, cancer, and neurodegeneration).
Catherine, Brenner, Maryline, Moulin
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The permeability transition pore in cell death [PDF]
Apoptosis, 2007 The permeability transition pore (PT-pore) is a multi-component protein aggregate in mitochondria that comprises factors in the inner as well as in the outer mitochondrial membrane. This complex has two functions: firstly, it regulates the integration of oxidative phosphorylation into the cellular energy household and secondly, it induces cell death ...
Stefan, Grimm, Dieter, Brdiczka
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Increased susceptibility of striatal mitochondria to calcium-induced permeability transition [PDF]
, 2003 Mitochondria were simultaneously isolated from striatum and cortex of adult rats and compared in functional assays for their sensitivity to calcium activation of the permeability transition.
Brustovetsky, T +11 more
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Loss of DJ-1 does not affect mitochondrial respiration but increases ROS production and mitochondrial permeability transition pore opening. [PDF]
PLoS ONE, 2012 Loss of function mutations in the DJ-1 gene have been linked to recessively inherited forms of Parkinsonism. Mitochondrial dysfunction and increased oxidative stress are thought to be key events in the pathogenesis of Parkinson's disease. Although it has
Emilie Giaime +4 more
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