Results 31 to 40 of about 2,782,679 (244)
Imaging the Permeability Pore Transition in Single Mitochondria [PDF]
Biophysical Journal, 1998 In mitochondria the opening of a large proteinaceous pore, the "mitochondrial permeability transition pore" (MTP), is known to occur under conditions of oxidative stress and matrix calcium overload. MTP opening and the resulting cellular energy deprivation have been implicated in processes such as hypoxic cell damage, apoptosis, and neuronal ...
Hüser, Jörg +2 more
openaire +2 more sources
The mitochondrial permeability transition pore in Ca2+ homeostasis
Cell Calcium, 2023 The mitochondrial Permeability Transition Pore (PTP) can be defined as a Ca2+ activated mega-channel involved in mitochondrial damage and cell death, making its inhibition a hallmark for therapeutic purposes in many PTP-related paradigms. Although long-lasting PTP openings have been widely studied, the physiological implications of transient openings ...
Michela Carraro, Paolo Bernardi
openaire +2 more sources
Nature Communications, 2021 The nature of the mitochondrial permeability transition pore (PTP) is still under debate. Here, through genetically modified F-ATP synthase, the authors show that PTP formation can be mediated by F-ATP synthase or by adenine nucleotide translocator ...
Andrea Carrer +10 more
doaj +1 more source
Both ANT and ATPase are essential for mitochondrial permeability transition but not depolarization
iScience, 2022 Summary: An increase in permeability of the mitochondrial inner membrane, mitochondrial permeability transition (PT), is the central event responsible for cell death and tissue damage in conditions such as stroke and heart attack.
M.A. Neginskaya +2 more
doaj +1 more source
Effect of hydrate nucleation mechanisms and capillarity on permeability reduction in granular media
Geophysical Research Letters, 2016 A model for water permeability reduction in hydrate‐bearing sediments is presented by considering capillary effect in hydrate nucleation. Both grain‐coating and pore‐filling cases are considered.
Dong Hun Kang +3 more
doaj +1 more source
PKCε and cardioprotection : an exploration of putative mechanisms [PDF]
, 2006 Includes bibliographical references.Recent studies have investigated the underlying regulatory mechanisms that may explain the cardioprotective role of PKCε.
McCarthy, Joy
core +1 more source
The molecular composition of the mitochondrial permeability transition pore [PDF]
Journal of Molecular and Cellular Cardiology, 2009 Uncontrolled cell death is a fundamental cause of organ disease in humans. However, despite the need for us to delineate the molecular machinery that underlies cardiomyocyte death, our knowledge of these lethal cellular processes is still limited. The discovery that mitochondrial dysfunction, and in particular the mitochondrial permeability transition (
openaire +2 more sources
The Depositional Record, 2022 This study evaluates variations in petrophysical properties within a mixed alluvial to lacustrine carbonate system (Miocene, Madrid Basin, Central Spain).
John J. G. Reijmer +5 more
doaj +1 more source
Mitochondrial Permeability Transition: A Pore Intertwines Brain Aging and Alzheimer’s Disease
Cells, 2021 Advanced age is the greatest risk factor for aging-related brain disorders including Alzheimer’s disease (AD). However, the detailed mechanisms that mechanistically link aging and AD remain elusive.
Kun Jia, Heng Du
doaj +1 more source
Applied SciencesDeep rock engineering is affected by coupled thermal, mechanical, and hydraulic processes, and the accurate prediction of permeability evolution is important for underground energy development and engineering safety.
Xueying Liu +5 more
doaj +1 more source