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A Systematic Quantitative Evaluation of Permeation Enhancement Window: Transdermal Permeation Enhancing Dynamics Establishment and Molecular Mechanisms Characterization of Permeation Enhancer [PDF]
Journal of Pharmaceutical Sciences, 2022 At present, transdermal permeation enhancing dynamics studies on permeation enhancers are still limited. In this study, these dynamics were established based on the content of enhancer Plurol Oleique CC in skin (CPOCC) and the increment of drug permeation amount (ΔQ).
Jiuheng Ruan +5 more
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PHARMACEUTICAL WORLD OF PERMEATION ENHANCERS
International Journal of Current Pharmaceutical Research, 2021 The drugs with poor solubility results in delayed absorption which consequently affects the bioavailability. There are many drugs which are having good therapeutic value but not used commercially because of this reason. The permeation enhancers are therefore being utilized to counter this problem.
MANISH KUMAR, DEEPAK PRASHAR
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Preactivated thiomers: Permeation enhancing properties
International Journal of Pharmaceutics, 2012 The study was aimed to prepare a series of poly(acrylic acid)-cysteine-2-mercaptonicotinic acid conjugates (preactivated thiomers) and to evaluate the influence of molecular mass or degree of preactivation with 2-mercaptonicotinic acid (2MNA) on their permeation enhancing properties.
Wang, Xueqing +3 more
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Electret Enhances Transdermal Drug Permeation
Biological and Pharmaceutical Bulletin, 2008 Electrets are polymeric discs that carry semi permanent electrostatic charge. These provide electrostatic potentials in the range of 500 to 3,000 V. In the current work, the effect of electret exposure on the skin permeability was investigated. Transdermal transport studies were carried out across porcine epidermis in Franz diffusion cells.
Narasimha Sathyanarayana, Narasimha Sathyanarayana Murthy +2 more
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Intestinal permeation enhancers for oral peptide delivery [PDF]
Advanced Drug Delivery Reviews, 2016 Intestinal permeation enhancers (PEs) are one of the most widely tested strategies to improve oral delivery of therapeutic peptides. This article assesses the intestinal permeation enhancement action of over 250 PEs that have been tested in intestinal delivery models.
Maher, Sam +2 more
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Percutaneous Permeation Enhancement by Terpenes: Mechanistic View [PDF]
The AAPS Journal, 2008 A popular approach for improving transdermal drug delivery involves the use of penetration enhancers (sorption promoters or accelerants) which penetrate into skin to reversibly reduce the barrier resistance. The potential mechanisms of action of penetration enhancers include disruption of intercellular lipid and/or keratin domains and tight junctions ...
Bharti, Sapra +2 more
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Combining Chemical Permeation Enhancers for Synergistic Effects
European Journal of Drug Metabolism and Pharmacokinetics, 2015 Currently, macromolecular drugs such as proteins are mainly administered by means of injections due to their low intestinal epithelial permeability and poor stability in the gastrointestinal tract. This study investigated binary combinations of chemical drug absorption enhancers to determine if synergistic drug absorption enhancement effects exist ...
Trizel du Toit +6 more
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Synergy between chemical permeation enhancers and drug permeation across the tympanic membrane [PDF]
Journal of Controlled Release, 2018 Chemical permeation enhancers (CPEs) can enable antibiotic flux across the tympanic membrane. Here we study whether combinations of CPEs (sodium dodecyl sulfate, limonene, and bupivacaine hydrochloride) are synergistic and whether they could increase the peak drug flux. Synergy is studied by isobolographic analysis and combination indices.
Rong, Yang +3 more
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Pharmaceutics, 2022 The greatest achievement in the advanced drug delivery field should be the optimization of non-invasive formulations for the delivery of high molecular weight compounds. Peptides, proteins, and other macromolecules can have poor membrane permeation, principally due to their large molecular weight.
Adriana Fantini +7 more
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Permeation enhancer strategies in transdermal drug delivery
Drug Delivery, 2014 Today, ∼74% of drugs are taken orally and are not found to be as effective as desired. To improve such characteristics, transdermal drug delivery was brought to existence. This delivery system is capable of transporting the drug or macromolecules painlessly through skin into the blood circulation at fixed rate.
Harneet, Marwah +3 more
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