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Comparative human and porcine skin permeation profiles of novel metformin lotion formulations. [PDF]
Zhao C +4 more
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Effect of Iontophoresis and Permeation Enhancers on the Permeation of an Acyclovir Gel
Current Drug Delivery, 2010The purpose of the present study was to explore the combined effect of chemical enhancers and iontophoresis on the in vitro permeation of acyclovir gel across porcine skin. Acyclovir gel was formulated using carbopol 940 and hydroxypropyl methylcellulose K4M (HPMC K4M). Effect of drug concentration on the delivery of acyclovir was examined.
Subhash S, Vaghani +6 more
openaire +2 more sources
Photothermal-Assisted Hydrogen Permeation Enhancement
Sensors and Actuators B: Chemical, 2022Herein, we propose and demonstrate a novel all-optical photothermal-assisted hydrogen permeation enhancement scheme by using a special optics-mechanics synergistic fiber optic hydrogen sensor. This design of the scheme is mainly based on the interdependencies between Pd-hydrogen reaction temperature and hydrogen permeation; as to observe the influence ...
Xinpu Zhang +5 more
openaire +1 more source
Effects of Adhesives and Permeation Enhancers on the Skin Permeation of Captopril
Drug Development and Industrial Pharmacy, 2001To formulate a transdermal drug delivery system of captopril, monolithic adhesive matrix type patches containing 20% captopril, different pressure-sensitive adhesives, and various permeation enhancers were prepared using a labcoater. The effects of the adhesives and permeation enhancers on skin permeation of captopril from the prepared patches were ...
E S, Park +3 more
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Homoharringtonine is a transdermal granular permeation enhancer
Biochemical and Biophysical Research Communications, 2022Although modulation of claudin-1-based tight junction (TJ) in stratum granulosum is an option for transdermal absorption of drugs, granular permeation enhancers have never been developed. We previously found that homoharringtonine (HHT), a natural alkanoid, weakened intestinal epithelial barrier with changing expression and cellular localization of TJ ...
Akihiro, Watari +6 more
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International Journal of Pharmaceutics, 1999
The use of a safe and effective permeation enhancer is paramount to the success of a buccal drug delivery system intended for systemic drug absorption. The enhancing effects of menthol (dissolved in an aqueous buffer in the absence of co-enhancers) on buccal permeation of a model hydrophilic nucleoside analog, dideoxycytidine (ddC), were investigated ...
Mansoor Khan
exaly +3 more sources
The use of a safe and effective permeation enhancer is paramount to the success of a buccal drug delivery system intended for systemic drug absorption. The enhancing effects of menthol (dissolved in an aqueous buffer in the absence of co-enhancers) on buccal permeation of a model hydrophilic nucleoside analog, dideoxycytidine (ddC), were investigated ...
Mansoor Khan
exaly +3 more sources
Intestinal Permeation Enhancers
Journal of Pharmaceutical Sciences, 2000This review addresses the field of improving oral bioavailability through the use of excipients that increase intestinal membrane permeability. The critical issues to consider in evaluating these approaches are 1) the extent of bioavailability enhancement achieved, 2) the influence of formulation and physiological variables, 3) toxicity associated with
openaire +2 more sources
Permeation Enhancers for Transdermal Drug Delivery
Drug Development and Industrial Pharmacy, 2000The transdermal route has been recognized as one of the highly potential routes of systemic drug delivery and provides the advantage of avoidance of the first-pass effect, ease of use and withdrawal (in case of side effects), and better patient compliance.
V R Sinha
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