Results 241 to 250 of about 136,012 (290)

Effect of permeation enhancers and organic acids on the skin permeation of indapamide

International Journal of Pharmaceutics, 2008
The aim of present study was to investigate the transdermal properties of indapamide and to explore the efficacy of various permeation enhancers and organic acids with regard to the percutaneous absorption of indapamide. Permeation experiments were performed in vitro, using rat abdominal skin as a barrier. In the permeation studies, 2-chamber diffusion
Changshun, Ren, Liang, Fang, Ting, Li, Manli, Wang, Ligang, Zhao, Zhonggui, He   +5 more
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Ocular Permeation Enhancers

2016
Nanotechnology-based penetration enhancers provide novel mechanisms to improve current drug delivery methodologies. New developments in this field have been shown to overcome previous difficulties of ocular therapeutics like anatomical barriers and filtration mechanisms.
Nathaniel J. Kim, Alon Harris, Alhasan Elghouche, Willy Gama, Brent Siesky   +4 more
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Effect of Permeation Enhancers on Buccal Absorption

Arzneimittelforschung, 2011
This paper reports an investigation on matrices based on the mucoadhesive polymers hydroxypropylmethylcellulose and sodium alginate, intended for sublingual administration of 1 mg lorazepam (LZ, 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one, CAS 846-49-1).
Susi, Burgalassi, Patrizia, Chetoni, Laura, Dini, Marcela, Najarro, Daniela, Monti, Paolo, Morelli, M Fabrizio, Saettone   +6 more
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Breaking Permeation Barriers of Charged Molecules with Excess Permeation Enhancers

The Journal of Physical Chemistry B
Abstract Permeation enhancers (PEs) are a class of amphiphilic molecules that promote the passive permeation of drug molecules through cellular membranes. There is currently a lack of understanding of the mechanism of action for permeation enhancers. Two PEs are studied in this manuscript, sodium caprate (C10) and salcaprozate sodium (
Mabel Bernaldez, Christopher Kang, Stephen D. Stamatis, John P. Rose, Rui Sun   +4 more
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Enhancement of transmucosal permeation of cyclosporine by benzalkonium chloride

Oral Diseases, 2002
OBJECTIVES: Permeation of cyclosporin A (CsA) through intact and de‐epithelialized human vaginal mucosa in the presence and absence of benzalkonium chloride (BZCl) was tested.MATERIALS AND METHODS: Human vaginal mucosa (snap‐frozen in liquid nitrogen, stored at −85°C) had been used for permeability experiments.
P, van der Bijl, A D, van Eyk, A A, Gareis, I O C, Thompson   +3 more
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[Influence of permeation enhancers on transdermal permeation of anemonin].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2008
To investigate the effect of different permeation enhancer on transdermal permeation of anemonin through human skin.The permeation experiments were performed using human skin on modified Franz diffusion cells in vitro. The concentrations of anemonin in receptor compartment at specified time points were determined by HPLC.
Yu-Ming, Ning, Yue-Feng, Rao, Wen-Quan, Liang   +2 more
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Mechanisms of oral permeation enhancement

International Journal of Pharmaceutics, 1997
This paper reviews the effects of a diverse range of penetration enhancers, including fatty acids, bile salts, surfactants, Azone® and ethanol, on oral mucosa. We describe in detail the effects on the intercellular lipid domains, the changes induced in proteinaceous regions and potential interactions between the enhancer and endogenous structures along
Ganem-Quintanar, A., Kalia, Yogeshvar, Falson-Rieg, F., Buri, Pierre   +3 more
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The Impact of Permeation Enhancers on Transcellular Permeation of Small Molecule Drugs

The Journal of Physical Chemistry B
Passive permeation through an epithelial membrane may be enhanced by using a class of amphiphilic molecules known as permeation enhancers (PEs). PEs have been studied in clinical trials and used in coformulations with peptides and small molecule drugs, and yet, an understanding of the permeant-PE interactions leaves much to be desired.
Mabel Bernaldez, Christopher Kang, Stephen D. Stamatis, John P. Rose, Rui Sun   +4 more
openaire   +2 more sources

Combining Chemical Permeation Enhancers for Synergistic Effects

European Journal of Drug Metabolism and Pharmacokinetics, 2015
Currently, macromolecular drugs such as proteins are mainly administered by means of injections due to their low intestinal epithelial permeability and poor stability in the gastrointestinal tract. This study investigated binary combinations of chemical drug absorption enhancers to determine if synergistic drug absorption enhancement effects exist ...
Trizel du Toit, Maides M. Malan, Hendrik J. R. Lemmer, Chrisna Gouws, Marique E. Aucamp, Wilma J. Breytenbach, Josias H. Hamman   +6 more
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Transdermal self-permeation enhancement of ibuprofen

Journal of Controlled Release, 2004
The objective of this study was to prepare saturated solutions of ibuprofen, of different concentrations, and to investigate their effect on permeation of ibuprofen across rat epidermis. Ibuprofen saturated solutions were prepared using 0.1, 0.2, 0.3 and 0.4 M disodium hydrogen phosphate solution (DHP).
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