Results 131 to 140 of about 74,776 (265)

Pathological Mechanism‐Inspired Biomimetic Nano‐Senotherapy for Reversing Experimental Atherosclerosis in ApoE−/− Mice

Advanced Science, EarlyView.
The biomimetic self‐assembly nanomedicine reversing atherosclerosis via senotherapy strategy. ABSTRACT The greatest challenge in atherosclerosis (AS) management lies in achieving lesion reversal, not merely slowing progression. Senescent cell accumulation—driven by continuous generation and apoptotic resistance—perpetuates plaque pathology and ...
Yuhan Tian, Yanrui Yang, Qiuyu Li, Ying Hu, Qin Hu, Shasha Ran, Siyu Zhou, Xiujuan Yang, Shanshan Li, Qixiong Zhang   +9 more
wiley   +1 more source

Gauging lipid vulnerabilities in mRNA-LNPs under various environmental stressors through TIMS-TOF analysis. [PDF]

RSC Adv
Girgis M, Saed A, Alishetty S, Carrasco M, O'neill D, Baby N, Petruncio G, Hoemann C, Albano M, Peng X, Wang B, Forsberg E, Rahil MN, Saleh A, Paige M.   +14 more
europepmc   +1 more source

Histone Modification Complex JMJ704‐HDA709 Negatively Regulates Salinity Tolerance in Rice

Advanced Science, EarlyView.
This study reveals that the rice histone demethylase JMJ704 interacts with HDA709―a H3K9ac deacetylase characterized herein―to form a chromatin‐modifying complex. Under salt stress, OsWRKY72 recruits this complex through interaction with JMJ704 to target loci, repressing the expression of oxidative stress and salt‐responsive genes via removal of ...
Jing Wang, Zhengting Chen, Pengxiang Bai, Biao Liu, Lingling Meng, Jian Zhang, Xu Li, Dao‐Xiu Zhou, Xuan Ma, Yu Zhao   +9 more
wiley   +1 more source

Application of Silibinin Oleate as a Nutraceutical Antioxidant for Improving the Quality of Sunflower Oil. [PDF]

Molecules
Dehelean CA, Oancea C, Neamtu AA, Enache V, Alexa VE, Cocan I, Suba M, Pricop MA, Lukinich-Gruia AT, Tatu CA, Alexa E.   +10 more
europepmc   +1 more source

An Edible Biohybrid Platform Accomplishes In Situ Fenton‐Mediated Enteral Nanoplastics Aging and Excretion

Advanced Science, EarlyView.
An edible biohybrid platform triggers nanoplastics (NPs) aging and agglomeration by in situ generating hydroxyl radicals within the intestine. The enlarged NPs are unable to penetrate the intestine and are subsequently excreted. Simultaneously, probiotic biofilms reinforce the intestinal barrier.
Su Zhou, Anran Yan, Haowei Guo, Ping Chen, Qiang Chu   +4 more
wiley   +1 more source

Targeting Ferroptosis to Overcome Radioresistance and Enhance Immunotherapy in Colorectal Cancer. [PDF]

Cells
Soltani Tehrani S, Olson SI, Kundu K, Ferrandon S, Kalady MF.   +4 more
europepmc   +1 more source

Multi‐Stimuli‐Responsive Hydrogen‐Bonded Organic Frameworks Nanocarriers Enable Targeted Fungicide Release and Plant Immune Regulation

Advanced Science, EarlyView.
A fluorinated hydrogen‐bonded organic framework nanocarrier (PFC‐1‐F) loaded with PYR and coated with HACC enables multi‐stimuli‐responsive (enzyme/ROS/pH) release at infection sites. Exhibiting targeted antifungal activity against Sclerotium rolfsii, modulating plant antioxidant defense, and demonstrating favorable biosafety across plant, soil, and ...
Guangming Ma, Ying Zou, Yao Wang, Huiyan Li, Jinlin Li, Tianfu Liu, Xiaohong Pan   +6 more
wiley   +1 more source

Oxidized PDI promotes thrombus formation in oxidative stress. [PDF]

Blood
Yang M, Owegie OC, Patel A, Kennedy QP, Flaumenhaft JT, Chinnaraj M, Ponzar N, Fulcidor EM, Rico MC, Bhowmik A, Carroll KS, Handy DE, Loscalzo J, Essex DW, Pozzi N, Flaumenhaft R.   +15 more
europepmc   +1 more source

PDIA6–SCD1 Axis Rewires Lipid Metabolism to Drive Gastric Cancer Progression

Advanced Science, EarlyView.
Protein disulfide isomerase A6 (PDIA6) is identified as an oncogenic driver in gastric cancer. PDIA6 directly binds and stabilizes SCD1 by limiting its ubiquitin–proteasome‐mediated degradation, thereby sustaining monounsaturated fatty acid (MUFA)‐enriched lipid homeostasis and lipid metabolic reprogramming.
Zhen Tian, Yifan Cheng, Jiajie Zhou, Ruiqi Li, Shuai Zhao, Ben Li, Zijie Xu, Mengli Zi, Yayan Fu, Chenkai Zhang, Qiannan Sun, Shantanu Baral, Sen Wang, Daorong Wang   +13 more
wiley   +1 more source

Evaluation of Quality Changes in Huajiao Seed Oil During Different Storage Conditions. [PDF]

Foods
Peng X, Fu B, Liu H, Fang C, Kan J.
europepmc   +1 more source