Results 61 to 70 of about 32,727 (216)

Heat stress in spermatogenesis: a redox‐dependent decision network linking ROS, autophagy, and regulated cell death

Biological Reviews, EarlyView.
ABSTRACT Heat stress (HS) is an increasing threat to male reproductive health, disrupting spermatogenesis through complex and interdependent cellular responses within the seminiferous epithelium. Although excessive reactive oxygen species (ROS) production is a hallmark of HS, ROS also act as central regulators of cell fate decisions beyond their role ...
Ribrio Ivan Tavares Pereira Batista
wiley   +1 more source

Microorganisms: A Potential Source of Bioactive Molecules for Antioxidant Applications

Molecules, 2021
Oxidative stress originates from an elevated intracellular level of free oxygen radicals that cause lipid peroxidation, protein denaturation, DNA hydroxylation, and apoptosis, ultimately impairing cell viability.
Alka Rani, Khem Chand Saini, Felix Bast, Sanjeet Mehariya, Shashi Kant Bhatia, Roberto Lavecchia, Antonio Zuorro   +6 more
doaj   +1 more source

Discovery of Spilanthol Endoperoxide as a Redox Natural Compound Active against Mammalian Prx3 and Chlamydia trachomatis Infection

Antioxidants, 2020
Chlamydia trachomatis (Ct) is a bacterial intracellular pathogen responsible for a plethora of diseases ranging from blindness to pelvic inflammatory diseases and cervical cancer.
Rosine Dushime, Yunhuang Zhu, Hanzhi Wu, Daniel Saez, Kirtikar Shukla, Heather Brown-Harding, Maique W. Biavatti, Kimberly J. Nelson, Leslie B. Poole, William T. Lowther, Paul B. Jones, Cristina M. Furdui, Allen W. Tsang   +12 more
doaj   +1 more source

Peroxiredoxin Catalysis at Atomic Resolution [PDF]

Structure, 2016
Peroxiredoxins (Prxs) are ubiquitous cysteine-based peroxidases that guard cells against oxidative damage, are virulence factors for pathogens, and are involved in eukaryotic redox regulatory pathways. We have analyzed catalytically active crystals to capture atomic resolution snapshots of a PrxQ subfamily enzyme (from Xanthomonas campestris ...
Perkins, Arden, Parsonage, Derek, Nelson, Kimberly J., Ogba, O. Maduka, Cheong, Paul Ha-Yeon, Poole, Leslie B., Karplus, P. Andrew   +6 more
openaire   +3 more sources

The Role of Peroxiredoxins in Cancer Development

Biology, 2023
Peroxiredoxins (Prxs) are antioxidant enzymes with ubiquitous expression in human tissues. Prxs are expressed in archaea, bacteria, and eukaryota, often in multiple isoforms. Because of their abundant expression in different cellular organelles and extraordinary sensitivity to H2O2, Prxs are among the first defenses against oxidative stress.
Pratik Thapa, Hong Jiang, Na Ding, Yanning Hao, Aziza Alshahrani, Qiou Wei   +5 more
openaire   +3 more sources

First Report of a Peroxiredoxin Homologue in Jellyfish: Molecular Cloning, Expression and Functional Characterization of CcPrx4 from Cyanea capillata

Marine Drugs, 2014
We first identified and characterized a novel peroxiredoxin (Prx), designated as CcPrx4, from the cDNA library of the tentacle of the jellyfish Cyanea capillata.
Zengliang Ruan, Guoyan Liu, Beilei Wang, Yonghong Zhou, Jia Lu, Qianqian Wang, Jie Zhao, Liming Zhang   +7 more
doaj   +1 more source

Metal‐dependent regulated cell death: Molecular architecture and translational frontiers

iMeta, EarlyView.
Intracellular metal dyshomeostasis orchestrates distinct regulated cell death programs, including iron‐driven ferroptosis, copper‐mediated cuproptosis, calcicoptosis, newly designated zincoptosis, mnoptosis, and coptosis. This review systematically delineates their molecular architectures—spanning from Sorafenib‐induced lipid peroxidation and ...
Haoliang Hu, Zhe Chen, Yaqi Li, Jiayi Peng, Jiangang Cao, Hong Zhou, Mengqi Wang, Yuejia Du, Hailin Wu, Huiqin Zhao, Shifang Huang, Dianmei Yu, Meiqing Liu, Olga V. Shevchenko, Natalia Yu. Matveeva, Yiyuan Yang, Kerui Huang, Deguan Lv, Junxia Min, Linxi Chen, Fudi Wang   +20 more
wiley   +1 more source

Targeting the intratumoral microbiota to overcome cancer immunotherapy resistance

Interdisciplinary Medicine, EarlyView.
This review delineates the mechanisms of intratumoral microbiota in cancer immunotherapy resistance, and offers strategies for microbiota‐targeted precision immunotherapy. Abstract Cancer remains a significant global health threat. The tumor microenvironment (TME) is a sophisticated ecological niche that exerts a pivotal effect on treatment outcomes ...
Bufu Tang, Tong Jiang, Yaling Lin, Wei Zhang, Hongjie Fan, Minjie Yang, Bingzhe Li, Yaozu Liu, Changyu Li, Xuran Jin, Wen Zhang, Zhiping Yan, Qianqian Zhao, Xuefeng Kan, Xudong Qu   +14 more
wiley   +1 more source

Subchronic Exposure to Arsenic and Nickel Triggers Nitrosative Stress and Histological Alterations in the Rat Liver

Journal of Applied Toxicology, EarlyView.
ABSTRACT Environmental exposure to heavy metals poses a threat to human health. Several studies documented harmful effects on the liver after arsenic and nickel exposure at concentrations beyond permissible limits. Nevertheless, the impact of a simultaneous exposure to both elements on hepatic biochemistry and histology remains unelucidated. Therefore,
Thainá Iasbik‐Lima, Luiz Otávio Guimarães‐Ervilha, Isabela Pereira da Silva Bento, Renê Chagas da Silva, Mariana Machado‐Neves   +4 more
wiley   +1 more source

Cuproptosis Inducers in Cancer Therapy: State of the Art and Challenges

The Chemical Record, EarlyView.
Cuproptosis is emerging as a distinct copper‐dependent cell death pathway, highlighting copper as a potential metabolic vulnerability in cancer. This review examines how coordination chemistry, redox regulation, and nanomaterial design shape Cu reactivity and therapeutic outcomes.
Chiara Ragusa, Valentina Oliveri
wiley   +1 more source