Results 151 to 160 of about 95,453 (303)

From HBV to MASLD Cirrhosis: Mechanistic Insights and Therapeutic Strategies

Portal Hypertension &Cirrhosis, EarlyView.
This review examines the epidemiological shift from hepatitis B virus (HBV) to metabolic dysfunction‐associated steatotic liver disease (MASLD) as the leading cause of cirrhosis globally. It highlights the distinct pathogenic mechanisms between HBV and MASLD cirrhosis and discusses evolving diagnostic tools and therapeutic strategies tailored to the ...
Hanqi Yu, Hongfan Ding, Yang Huang, Haoze Cao, Yuan Ding, Weilin Wang   +5 more
wiley   +1 more source

Current Cell/Organoid and Animal Models for Primary Sclerosing Cholangitis

Portal Hypertension &Cirrhosis, EarlyView.
Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease with limited therapeutic options and a marked risk of progression to biliary fibrosis, cirrhosis, and malignancy. Progress in PSC research has been hindered by the lack of models that faithfully recapitulate the complex biliary microenvironment and disease heterogeneity ...
Qigu Yao, Sheng Cheng, Qiaoling Pan, Jiong Yu, Hongcui Cao   +4 more
wiley   +1 more source

Interplay of Ser273 Phosphorylation and K268 and K293 Acetylation in PPARγ: Implications for PPARγ Activation

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Post‐translational modifications (PTMs) play a critical role in regulating the transcriptional activity of PPARγ, a nuclear receptor central to glucose and lipid homeostasis. Among these, lysine acetylation at K268 and K293 and phosphorylation at S273 are particularly relevant to insulin sensitivity.
Caique Camargo Malospirito, Marieli Mariano Gonçalves Dias, Gabriel Ernesto Jara, Thayná Mendonça Avelino, Giovanna Blazutti Elias, Paulo Sergio Lopes de Oliveira, Ana Carolina Migliorini Figueira   +6 more
wiley   +1 more source

Melatonin and Its Metabolites Can Serve as Agonists on the Aryl Hydrocarbon Receptor and Peroxisome Proliferator-Activated Receptor Gamma. [PDF]

Int J Mol Sci, 2023
Slominski AT, Kim TK, Slominski RM, Song Y, Qayyum S, Placha W, Janjetovic Z, Kleszczyński K, Atigadda V, Song Y, Raman C, Elferink CJ, Hobrath JV, Jetten AM, Reiter RJ.   +14 more
europepmc   +1 more source

Noise‐Induced Hearing Loss: From Pathological Mechanisms to Therapeutic Interventions

Sensory Neuroscience, EarlyView.
ABSTRACT Noise‐induced hearing loss (NIHL), a significant non‐genetic form of hearing impairment, is primarily managed through the use of hearing aids and cochlear implants. However, the fundamental pathological mechanisms underlying NIHL remain inadequately addressed.
Shiqi Huang, Yu Xiao, Jiaxin Liu, Wen Jiang, Weiwei Shi, Hanbing Zhang, Xiaolong Fu, Yunhao Wu   +7 more
wiley   +1 more source

Peroxisome proliferator-activated receptor gamma (PPARγ) activation: a potential treatment for ascites syndrome in broiler chickens. [PDF]

Poult Sci, 2023
Rahimi M, Rahimi S, Karimi Torshizi MA, Sharafi M, Masoudi AA, Grimes JL.   +5 more
europepmc   +1 more source

Seladelpar Improved Itch, Itch‐Related Sleep Disturbance and Measures of Fatigue in Patients With Primary Biliary Cholangitis and Pruritus in the Phase 3 RESPONSE Trial

Alimentary Pharmacology &Therapeutics, EarlyView.
Seladelpar improved itch, itch‐related sleep disturbance and measures of fatigue in patients with primary biliary cholangitis and pruritus in the Phase 3 RESPONSE trial. ABSTRACT Background Pruritus and fatigue impose a significant burden on patient quality of life in primary biliary cholangitis (PBC).
Cynthia Levy, David E. J. Jones, Marlyn J. Mayo, Christopher L. Bowlus, Kris V. Kowdley, Gideon M. Hirschfield, Jie Liu, Caroline Burk, Susheela Carroll, Daria B. Crittenden, Andreas E. Kremer   +10 more
wiley   +1 more source

Pro115Gln peroxisome proliferator-activated receptor-gamma and obesity. [PDF]

Diabetes Care, 2000
A R, Shuldiner, W, Nguyen, W H, Kao, B A, Beamer, R E, Andersen, R, Pratley, F L, Brancati   +6 more
openaire   +2 more sources

A multicentre analysis of efficacy, safety and molecular response correlates of fostamatinib in warm autoimmune haemolytic anaemia and Evans syndrome

British Journal of Haematology, EarlyView.
Fostamatinib had 46% durable response, with 73% steroid reduction, in this multicentre retrospective study of refractory wAIHA/ES. Hypertension, gastrointestinal (GI) distress and neutropenia occurred in 23%. Only one patient required drug discontinuation and one patient dose reduction.
Jorge N. Ruiz Lopez, Lipei Shao, Debbie Jiang, Lawrence S. Bailey, Thejaswi Bikkani, Aaron Boothby, Donald C. Moore, Irina Murakhovskaya, Caroline I. Piatek, Mauricio Pineda‐Roman, Ping Jin, Jacqueline N. Poston, Moritz Stolla, David F. Stroncek, Krystalyn E. Hudson, James B. Bussel, Sandhya R. Panch   +16 more
wiley   +1 more source

High glucose inhibits neural differentiation by excessive autophagy via peroxisome proliferator-activated receptor gamma. [PDF]

Eur J Histochem, 2023
Pan Y, Qiu D, Chen S, Han X, Li R.
europepmc   +1 more source