Defective protein persulfidation is involved in obesity associated skeletal muscle dysfunction: role of SIRT-1 [PDF]
Redox BiologyEctopic fat deposition in skeletal muscle (SKM) due to obesity leads to biochemical and morphological alterations that deteriorate SKM quality and performance.
M. Smimmo +23 more
doaj +5 more sources
Metabolic dysfunction-associated steatohepatitis reduces hepatic H2S-producing enzymes altering persulfidome composition [PDF]
Redox BiologyMetabolic dysfunction–associated steatohepatitis (MASH) is a progressive disease driven by obesity-related hepatic inflammation and oxidative stress.
Tzu Keng Shen +17 more
doaj +5 more sources
Hydrogen Sulfide: A Key Role in Autophagy Regulation from Plants to Mammalians [PDF]
Antioxidants, 2022 Autophagy is a degradative conserved process in eukaryotes to recycle unwanted cellular protein aggregates and damaged organelles. Autophagy plays an important role under normal physiological conditions in multiple biological processes, but it is induced
Angeles Aroca, Cecilia Gotor
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Hydrogen Sulfide Signaling in Plants: Emerging Roles of Protein Persulfidation [PDF]
Frontiers in Plant Science, 2018 Hydrogen sulfide (H2S) has been largely referred as a toxic gas and environmental hazard, but recent years, it has emerged as an important gas-signaling molecule with effects on multiple physiological processes in both animal and plant systems.
Angeles Aroca +2 more
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Protein Persulfidation in Plants: Function and Mechanism [PDF]
Antioxidants, 2021 As an endogenous gaseous transmitter, the function of hydrogen sulfide (H2S) has been extensively studied in plants. Once synthesized, H2S may be involved in almost all life processes of plants.
Peng Wang +3 more
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Functional S-persulfidation exploration reveals a novel regulatory mechanism of HNF1α [PDF]
Redox BiologyProtein S-persulfidation, a post-translational modification mediated by hydrogen sulfide (H2S), plays an essential role in regulating protein function. However, current profiling methods, mainly based on liquid chromatography-tandem mass spectrometry (LC-
Yaqian Huang +22 more
doaj +2 more sources
New role for thioredoxins in plants: Implication of TRXo1 in protein depersulfidation [PDF]
Redox BiologyPersulfidation, a posttranslational modification of cysteines to persulfides, is the best characterized molecular mechanism of H2S signaling. This study is focused on new functions for thioredoxins (TRXs) in plants beyond those of thiol disulfide (S–S ...
Sabrina De Brasi-Velasco +5 more
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The Role of Ferroptosis in Diabetes Pathogenesis: Therapeutic Implications of Hydrogen Sulfide and Its Reactive Metabolites [PDF]
AntioxidantsFerroptosis, a regulated form of cell death characterized by iron-dependent lipid peroxidation, emerged as an important contributor to the pathogenesis of diabetes and its complications.
Vesna Otasevic +7 more
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Persulfidation alters gene regulatory programs and promotes endothelial specification [PDF]
Redox BiologyEndogenously generated sulfides are conserved among species and tissues and exert multiple effects through diverse mechanisms. Although sulfides have been linked to cell fates, their role in pluripotent stem cell commitment remains unknown.
Janina Wittig +16 more
doaj +2 more sources
Harshly Oxidized Activated Charcoal Enhances Protein Persulfidation with Implications for Neurodegeneration as Exemplified by Friedreich’s Ataxia [PDF]
NanomaterialsHarsh acid oxidation of activated charcoal transforms an insoluble carbon-rich source into water-soluble, disc structures of graphene decorated with multiple oxygen-containing functionalities. We term these pleiotropic nano-enzymes as “pleozymes”.
Anh T. T. Vo +9 more
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