Results 121 to 130 of about 444 (152)
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Journal of the American Chemical Society, 2017
A general strategy of delivering hydrogen persulfide (H2S2) is described herein. Esterase- and phosphatase-sensitive H2S2 prodrugs with tunable release rates have been synthesized. Their utility is validated in examining protein S-persulfidation. With this unique approach of directly delivering H2S2, our findings reaffirmed that S-persulfidation leads ...
Bingchen Yu +9 more
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A general strategy of delivering hydrogen persulfide (H2S2) is described herein. Esterase- and phosphatase-sensitive H2S2 prodrugs with tunable release rates have been synthesized. Their utility is validated in examining protein S-persulfidation. With this unique approach of directly delivering H2S2, our findings reaffirmed that S-persulfidation leads ...
Bingchen Yu +9 more
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Targeted Delivery of Persulfides to the Gut: Effects on the Microbiome
Angewandte Chemie, 2021AbstractPersulfides (R−SSH) have been hypothesized as potent redox modulators and signaling compounds. Reported herein is the synthesis, characterization, and in vivo evaluation of a persulfide donor that releases N‐acetyl cysteine persulfide (NAC‐SSH) in response to the prokaryote‐specific enzyme nitroreductase.
Kearsley M. Dillon +8 more
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Esterase-Sensitive Glutathione Persulfide Donor
Organic Letters, 2018An esterase-sensitive glutathione persulfide (GSSH) donor (BW-GP-401) is described. The release profile was studied by monitoring the formation of lactone and direct trapping of GSSH with 1-fluoro-2,4-dinitrobenzene (DNFB). The donor was examined for its inhibitory effect toward glyceraldehyde 3-phosphate dehydrogenase (GAPDH).
Zhengnan Yuan +5 more
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Biochemical Functions of Persulfides
1982In biological systems, persulfides (RSS-) are reactive, unstable intermediates in the transformations of sulfur compounds. Persulfides are also referred to as polysulfides, or alkyl/aryl hydrogen disulfides. The persulfide sulfur is commonly termed, “sulfane”, to designate sulfur covalently bonded only to other sulfur atoms.
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Persulfidation proteome reveals the regulation of protein function by hydrogen sulfide in diverse biological processes in Arabidopsis [PDF]
Journal of Experimental Botany, 2017 Hydrogen sulfide-mediated signaling pathways regulate many physiological and pathophysiological processes in mammalian and plant systems. The molecular mechanism by which hydrogen sulfide exerts its action involves the post-translational modification ...
Angeles Aroca +2 more
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Biological chemistry of hydrogen sulfide and persulfides
Archives of Biochemistry and Biophysics, 2017Hydrogen sulfide (H2S) has been traditionally considered to be a toxic molecule for mammals. However, it can be formed endogenously and exert physiological effects with potential health benefits. H2S can partition two-fold in biological membranes and traverse them rapidly, diffusing between compartments.
Ernesto, Cuevasanta +2 more
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Protein Persulfidation: Recent Progress and Future Directions
Antioxidants & Redox Signaling, 2023Significance: Hydrogen sulfide (H 2 S) is considered to be a gasotransmitter along with carbon monoxide (CO) and nitric oxide (NO), and is known as a key regulator of physiological and pathological activities.
Shanshan Luo +8 more
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Persulfidation (S-sulfhydration) and H2S
2015The past decade has witnessed the discovery of hydrogen sulfide (H2S) as a new signalling molecule. Its ability to act as a neurotransmitter, regulator of blood pressure, immunomodulator or anti-apoptotic agent, together with its great pharmacological potential, is now well established.
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ProPerDP: A Protein Persulfide Detection Protocol
2019Persulfide or polysulfide formation on Cys residues is emerging as an abundant protein posttranslational modification, with important regulatory functions. However, as many other Cys oxidative modifications, per- and polysulfides are relatively labile, dynamically interchanging species, which makes their intracellular detections challenging.
Éva, Dóka +3 more
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Persulfides, at the crossroads between hydrogen sulfide and thiols
Essays in Biochemistry, 2020Abstract Persulfides (RSSH/RSS−) can be formed in protein and non-protein thiols (RSH) through several different pathways, some of which are dependent on hydrogen sulfide (H2S/HS−). In addition to their roles in biosynthetic processes, persulfides are possible transducers of physiological effects of H2S through the modification of ...
Dayana Benchoam +3 more
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