Hydrogen Sulfide: From a Toxic Molecule to a Key Molecule of Cell Life [PDF]
Antioxidants, 2020 Hydrogen sulfide (H2S) has always been considered toxic, but a huge number of articles published more recently showed the beneficial biochemical properties of its endogenous production throughout all regna.
Angeles Aroca +3 more
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Dual Roles of Reducing Systems in Protein Persulfidation and Depersulfidation [PDF]
AntioxidantsThe oxidative modification of specific cysteine residues to persulfides is thought to be the main way by which hydrogen sulfide (H2S) exerts its biological and signaling functions. Therefore, protein persulfidation represents an important thiol-switching
Zhichao Liu +2 more
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A persulfidation-based mechanism controls aquaporin-8 conductance [PDF]
Science Advances, 2018 Upon engagement of tyrosine kinase receptors, nicotinamide adenine dinucleotide phosphate (NADPH)-oxidases release H2O2 in the extracellular space.
Bestetti, Stefano +8 more
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Cysteine-rich zinc finger proteins and the nuclear factor kappa-B pathway [PDF]
Frontiers in Chemical BiologyInflammation-related disorders, such as autoimmune diseases and cancer, impose a significant global health burden. Zinc finger proteins (ZFs) are ubiquitous metalloproteins which regulate inflammation and many biological signaling pathways related to ...
Andrew T. Stoltzfus, Sarah L. J. Michel
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Reactive Sulfur Species and Protein Persulfidation: An Emerging Redox Axis in Human Health and Disease [PDF]
Current Issues in Molecular BiologyReactive sulfur species (RSS)—hydrogen sulfide (H2S), low-molecular-weight persulfides/polysulfides and protein persulfidation—constitute a third redox axis alongside ROS and RNS.
Celia María Curieses Andrés +5 more
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Persulfidation of Human Cystathionine γ-Lyase Inhibits Its Activity: A Negative Feedback Regulation Mechanism for H2S Production [PDF]
AntioxidantsCystathionine γ-lyase (CSE) is the second enzyme in the trans-sulfuration pathway that converts cystathionine to cysteine. It is also one of three major enzymes responsible for the biosynthesis of hydrogen sulfide (H2S).
Guanya Jia +8 more
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Persulfidation of DJ-1: Mechanism and Consequences
Biomolecules, 2022 DJ-1 (also called PARK7) is a ubiquitously expressed protein involved in the etiology of Parkinson disease and cancers. At least one of its three cysteine residues is functionally essential, and its oxidation state determines the specific function of the
Erwan Galardon +5 more
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Plant catalases as NO and H2S targets [PDF]
Redox Biology, 2020 Catalase is a powerful antioxidant metalloenzyme located in peroxisomes which also plays a central role in signaling processes under physiological and adverse situations. Whereas animals contain a single catalase gene, in plants this enzyme is encoded by
José M. Palma +6 more
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Hydrogen sulfide protects against spinal cord pyroptosis via persulfidation of Rac1 after lumbosacral plexus nerve injury [PDF]
Cell Death DiscoveryPyroptosis, a form of lytic and inflammatory programmed cell death mediated by gasdermin proteins, contributes to progressive spinal cord neurodegeneration following neural trauma.
Jianyu Mao +9 more
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Profiling the landscape of cysteine posttranslational modifications in brain aging and neurodegeneration [PDF]
NeurotherapeuticsCysteine residues occupy a unique position in the proteome: their thiolate side chain combines high nucleophilicity with redox sensitivity, making them prime targets for a diverse and ever-expanding array of post-translational modifications (PTMs).
Milos R. Filipovic
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