Discovery of a Redox Thiol Switch: Implications for Cellular Energy Metabolism [PDF]
, 2020 The redox-based modifications of cysteine residues in proteins regulate their function in many biological processes. The gas molecule H2S has been shown to persulfidate redox sensitive cysteine residues resulting in an H2S-modified proteome known as the ...
Abbott, Derek +11 more
core +2 more sources
The anti-inflammatory effect of dimethyl trisulfide in experimental acute pancreatitis [PDF]
, 2023 Various organosulfur compounds, such as dimethyl trisulfide (DMTS), display anti-inflammatory properties. We aimed to examine the effects of DMTS on acute pancreatitis (AP) and its mechanism of action in both in vivo and in vitro studies.
Al-omari Ammar +18 more
core +1 more source
Fermentation, 2022 Hydrogen sulfide (H2S) is a gas produced endogenously in organisms from the three domains of life. In mammals, it is involved in diverse physiological processes, including the regulation of blood pressure and its effects on memory.
Emilio Espinoza-Simón +6 more
doaj +1 more source
Regulation of the T-type Ca²⁺ channel Cav3.2 by hydrogen sulfide: Emerging controversies concerning the role of H₂S in nociception [PDF]
, 2015 Ion channels represent a large and growing family of target proteins regulated by gasotransmitters such as nitric oxide, carbon monoxide and, as described more recently, hydrogen sulfide.
Abe +102 more
core +2 more sources
Synthetic Motifs for Understanding Lewis Acid Interactions with Persulfides and Thioselenides
Angewandte Chemie, Volume 138, Issue 3, 16 January 2026.Using isolated dichalcogenides as precursors, we report the synthesis, characterization, and reactivity of Zn persulfide and thioselenide complexes. 77Se NMR shows distinct impacts to electronic structure and reactivity between different thioselenides coordinated to different Lewis acids.
Keyan Li +3 more
wiley +2 more sources
H2S Persulfidated and Increased Kinase Activity of MPK4 to Response Cold Stress in Arabidopsis
Frontiers in Molecular Biosciences, 2021 Hydrogen sulfide (H2S) is a gasotransmitter along with nitric oxide and carbon oxide, which is involved in plant growth and development as well as biotic and abiotic stress resistance.
Xinzhe Du +10 more
doaj +1 more source
Molecular responses of legumes to abiotic stress: Post-translational modifications of proteins and redox signaling [PDF]
, 2021 Legumes include several major crops that can fix atmospheric nitrogen in symbiotic root nodules, thus reducing the demand for nitrogen fertilizers and contributing to sustainable agriculture.
Becana, Manuel, Matamoros, Manuel A.
core +1 more source
Genetic Links Between Hydrogen Sulfide Pathways and Risk of Alzheimer's Disease and Related Risk Factors: A Phenome‐Wide Approach [PDF]
Alzheimers DementAbstract Background Hydrogen sulfide (H2S) is a promising therapeutic drug target for various pathologies, including Alzheimer's disease (AD) and related dementias (ADRD). The newly recognized gasotransmitter freely permeates cellular membranes and is vital to maintaining homeostasis, primarily via smooth muscle relaxation and vasodilatory mechanisms ...
Brady J, Reay W.
europepmc +2 more sources
Anomalous Kv 7 channel activity in human malignant hyperthermia syndrome unmasks a key role for H2 S and persulfidation in skeletal muscle. [PDF]
BACKGROUND AND PURPOSE: Human malignant hyperthermia (MH) syndrome is induced by volatile anaesthetics and involves increased levels of cystathionine β-synthase (CBS)-derived H2 S within skeletal muscle.
Basso Elisabetta, Maria +15 more
core +1 more source
Persulfide Biosynthesis Conserved Evolutionarily in All Organisms
Antioxidants & Redox Signaling, 2023 Significance: Persulfides/polysulfides are sulfur-catenated molecular species (i.e., R-Sn-R', n > 2; R-Sn-H, n > 1, with R = cysteine, glutathione, and proteins), such as cysteine persulfide (CysSSH). These species are abundantly formed as endogenous metabolites in mammalian and human cells and tissues.
Seiryo Ogata +5 more
openaire +2 more sources