Results 1 to 10 of about 4,338 (207)

Protocol for using organic persulfides to measure the chemical reactivity of persulfide sensors

STAR Protocols, 2022
Summary: Hydrogen sulfide (H2S) and downstream reactive sulfur species (RSS), including organic persulfides, protect bacterial cells against diverse oxidative stressors.
Joseph N. Fakhoury, Daiana A. Capdevila, David P. Giedroc   +2 more
doaj   +4 more sources

Enzymes that generate and regulate intracellular persulfides and polysulfides: mechanistic insights and inhibitors [PDF]

Frontiers in Physiology
Reactive sulfur species (RSS), which include various persulfides and polysulfides, are generated by multiple enzymes in vivo and play critical roles in mammalian physiological processes such as redox signaling, metabolic regulation, radical scavenging ...
Ko Hirabayashi, Eita Sasaki, Hisashi Ohno, Orie Takayama, Sota Yamada, Kenjiro Hanaoka, Kenjiro Hanaoka   +6 more
doaj   +2 more sources

Growth inhibitory factor/metallothionein-3 is a sulfane sulfur-binding protein [PDF]

eLife
Cysteine-bound sulfane sulfur atoms in proteins have received much attention as key factors in cellular redox homeostasis. However, the role of sulfane sulfur in zinc regulation has been underinvestigated.
Yasuhiro Shinkai, Yunjie Ding, Toru Matsui, George Devitt, Masahiro Akiyama, Tang-Long Shen, Motohiro Nishida, Tomoaki Ida, Takaaki Akaike, Sumeet Mahajan, Jon M Fukuto, Yasuteru Shigeta, Yoshito Kumagai   +12 more
doaj   +2 more sources

2-Thiouridine formation in Escherichia coli: a critical review [PDF]

Journal of Bacteriology
Modifications of transfer RNA (tRNA) have been shown to play critical roles in the biogenesis, metabolism, structural stability, and function of RNA molecules, and the specific modifications of nucleobases with sulfur atoms in tRNA are present in ...
Silke Leimkühler
doaj   +2 more sources

Cysteine trisulfide oxidizes protein thiols and induces electrophilic stress in human cells

Redox Biology, 2021
The cellular effects of hydrogen sulfide (H2S) signaling may be partially mediated by the formation of alkyl persulfides from thiols, such as glutathione and protein cysteine residues.
Christopher H. Switzer, Sebastian Guttzeit, Thomas R. Eykyn, Philip Eaton   +3 more
doaj   +1 more source

Saccharomyces cerevisiae Rhodanese RDL2 Uses the Arg Residue of the Active-Site Loop for Thiosulfate Decomposition

Antioxidants, 2021
Persulfide, polysulfide and thiosulfate are examples of sulfane sulfur containing chemicals that play multiple functions in biological systems. Rhodaneses are widely present in all three kingdoms of life, which catalyze sulfur transfer among these ...
Qingda Wang, Huanjie Li, Yongzhen Xia, Luying Xun, Huaiwei Liu   +4 more
doaj   +1 more source

Contribution of NRF2 to sulfur metabolism and mitochondrial activity

Redox Biology, 2023
NF-E2-related factor 2 (NRF2) plays a crucial role in the maintenance of cellular homeostasis by regulating various enzymes and proteins that are involved in the redox reactions utilizing sulfur.
Md Morshedul Alam, Akihiro Kishino, Eunkyu Sung, Hiroki Sekine, Takaaki Abe, Shohei Murakami, Takaaki Akaike, Hozumi Motohashi   +7 more
doaj   +1 more source

Possible molecular basis of the biochemical effects of cysteine-derived persulfides

Frontiers in Molecular Biosciences, 2022
Persulfides (RSSH/RSS−) are species closely related to thiols (RSH/RS−) and hydrogen sulfide (H2S/HS−), and can be formed in biological systems in both low and high molecular weight cysteine-containing compounds.
Ernesto Cuevasanta, Ernesto Cuevasanta, Ernesto Cuevasanta, Dayana Benchoam, Dayana Benchoam, Dayana Benchoam, Jonathan A. Semelak, Matías N. Möller, Matías N. Möller, Ari Zeida, Ari Zeida, Madia Trujillo, Madia Trujillo, Beatriz Alvarez, Beatriz Alvarez, Darío A. Estrin   +15 more
doaj   +1 more source

Recent Advances in the Elucidation of Frataxin Biochemical Function Open Novel Perspectives for the Treatment of Friedreich’s Ataxia

Frontiers in Neuroscience, 2022
Friedreich’s ataxia (FRDA) is the most prevalent autosomic recessive ataxia and is associated with a severe cardiac hypertrophy and less frequently diabetes.
Beata Monfort, Kristian Want, Sylvain Gervason, Benoit D’Autréaux   +3 more
doaj   +1 more source

Enzymatic Regulation and Biological Functions of Reactive Cysteine Persulfides and Polysulfides

Biomolecules, 2020
Cysteine persulfide (CysSSH) and cysteine polysulfides (CysSSnH, n > 1) are cysteine derivatives that have sulfane sulfur atoms bound to cysteine thiol. Advances in analytical methods that detect and quantify persulfides and polysulfides have shown that ...
Tomohiro Sawa, Hozumi Motohashi, Hideshi Ihara, Takaaki Akaike   +3 more
doaj   +1 more source