Results 11 to 20 of about 4,338 (207)

Persulfidation of DJ-1: Mechanism and Consequences

Biomolecules, 2022
DJ-1 (also called PARK7) is a ubiquitously expressed protein involved in the etiology of Parkinson disease and cancers. At least one of its three cysteine residues is functionally essential, and its oxidation state determines the specific function of the
Erwan Galardon, Nicolas Mathas, Dominique Padovani, Laurent Le Corre, Gabrielle Poncet, Julien Dairou   +5 more
doaj   +3 more sources

Synthetic Motifs for Understanding Lewis Acid Interactions with Persulfides and Thioselenides. [PDF]

Angew Chem Int Ed Engl
Using isolated dichalcogenides as precursors, we report the synthesis, characterization, and reactivity of Zn persulfide and thioselenide complexes. 77Se NMR shows distinct impacts to electronic structure and reactivity between different thioselenides coordinated to different Lewis acids.
Li K, Sattler AJ, Zakharov LN, Pluth MD.
europepmc   +3 more sources

Toxic Tear Gas 2-Chloroacetophenone (CN) Forms Adducts With Endogenous Plasma Thiols In Vitro Valuable as Biomarkers of Exposure. [PDF]

Drug Test Anal
Incubation of human plasma with the tear gas 2‐chloroacetophenone (CN) led to the formation of acetophenone (AcPhen)‐adducts with the small plasma thiols glutathione, homocysteine, and cysteine persulfide. The AcPhen‐adducts were either bound to an organic thiol‐group or to an organic persulfide. The adducts were detected with a mass spectrometry‐based
Sieber PH, Steinritz D, Worek F, John H.
europepmc   +2 more sources

Therapeutic Efficacy of the Supersulfide Donor NAC-S2 in Influenza Virus Pneumonia via Suppression of Excessive Inflammatory Responses. [PDF]

Microbiol Immunol
ABSTRACT Influenza pneumonia is characterized by excessive inflammatory responses that contribute to severe lung injury and mortality. Supersulfides, endogenously produced cysteine‐derived persulfides and polysulfides, exert potent antioxidant, anti‐ferroptotic, and anti‐inflammatory activities; however, their therapeutic potential after disease onset ...
Hossen F, Kouwaki T, Fujiwara Y, Tsutsuki H, Zhang T, Guo C, Rahman A, Komohara Y, Oshiumi H, Sawa T.   +9 more
europepmc   +2 more sources

Commonly Used Alkylating Agents Limit Persulfide Detection by Converting Protein Persulfides into Thioethers

Angewandte Chemie, 2022
AbstractProtein persulfides (R‐S‐SH) have emerged as a common post‐translational modification. Detection and quantitation of protein persulfides requires trapping with alkylating agents. Here we show that alkylating agents differ dramatically in their ability to conserve the persulfide's sulfur–sulfur bond for subsequent detection by mass spectrometry.
Danny Schilling, Uladzimir Barayeu, Raphael R. Steimbach, Deepti Talwar, Aubry K. Miller, Tobias P. Dick   +5 more
openaire   +2 more sources

Direct Proteomic Mapping of Cysteine Persulfidation [PDF]

Antioxidants & Redox Signaling, 2020
Aims: Cysteine persulfidation (also called sulfhydration or sulfuration) has emerged as a potential redox mechanism to regulate protein functions and diverse biological processes in hydrogen sulfide (H2S) signaling. Due to its intrinsically unstable nature, working with this modification has proven to be challenging.
Ling, Fu, Keke, Liu, Jingyang, He, Caiping, Tian, Xiaobo, Yu, Jing, Yang   +5 more
openaire   +2 more sources

Protein Persulfidation in Plants: Function and Mechanism [PDF]

Antioxidants, 2021
As an endogenous gaseous transmitter, the function of hydrogen sulfide (H2S) has been extensively studied in plants. Once synthesized, H2S may be involved in almost all life processes of plants. Among them, a key route for H2S bioactivity occurs via protein persulfidation, in which process oxidizes cysteine thiol (R-SH) groups into persulfide (R-SSH ...
Peng Wang, Hua Fang, Rong Gao, Weibiao Liao   +3 more
openaire   +3 more sources

Synthesis of Sulfides and Persulfides Is Not Impeded by Disruption of Three Canonical Enzymes in Sulfur Metabolism

Antioxidants, 2023
Reactive sulfur species, or persulfides and polysulfides, such as cysteine hydropersulfide and glutathione persulfide, are endogenously produced in abundance in both prokaryotes and eukaryotes, including mammals.
Qamarul Hafiz Zainol Abidin, Tomoaki Ida, Masanobu Morita, Tetsuro Matsunaga, Akira Nishimura, Minkyung Jung, Naim Hassan, Tsuyoshi Takata, Isao Ishii, Warren Kruger, Rui Wang, Hozumi Motohashi, Masato Tsutsui, Takaaki Akaike   +13 more
doaj   +1 more source

Emerging Chemical Biology of Protein Persulfidation

Antioxidants & Redox Signaling, 2023
Significance: Protein persulfidation (the formation of RSSH), an evolutionarily conserved oxidative posttranslational modification in which thiol groups in cysteine residues are converted into persulfides, has emerged as one of the main mechanisms through which hydrogen sulfide (H2S) conveys its signaling.
Vignane, Thibaut, Filipovic, Milos R.
openaire   +2 more sources

Persulfide-Responsive Transcription Factor SqrR Regulates Gene Transfer and Biofilm Formation via the Metabolic Modulation of Cyclic di-GMP in Rhodobacter capsulatus

Microorganisms, 2022
Bacterial phage-like particles (gene transfer agents—GTAs) are widely employed as a crucial genetic vector in horizontal gene transfer. GTA-mediated gene transfer is induced in response to various stresses; however, regulatory mechanisms are poorly ...
Takayuki Shimizu, Toma Aritoshi, J. Thomas Beatty, Tatsuru Masuda   +3 more
doaj   +1 more source