Results 21 to 30 of about 4,338 (207)

Acidity and nucleophilic reactivity of glutathione persulfide [PDF]

Journal of Biological Chemistry, 2020
Les persulfures (RSSH/RSS−) participent au trafic de soufre et aux processus métaboliques, et sont proposés pour médier les effets de signalisation du sulfure d'hydrogène (H2S). Malgré leur pertinence croissante, leurs propriétés chimiques sont mal comprises.
Dayana Benchoam, Jonathan A. Semelak, Ernesto Cuevasanta, Mauricio Mastrogiovanni, Juan Santiago Grassano, Gerardo Ferrer‐Sueta, Ari Zeida, Madia Trujillo, Matías N. Möller, Darío A. Estrı́n, Beatriz Álvarez   +10 more
openaire   +4 more sources

Hydrogen Sulfide and Persulfides Oxidation by Biologically Relevant Oxidizing Species

Antioxidants, 2019
Hydrogen sulfide (H2S/HS⁻) can be formed in mammalian tissues and exert physiological effects. It can react with metal centers and oxidized thiol products such as disulfides (RSSR) and sulfenic acids (RSOH).
Dayana Benchoam, Ernesto Cuevasanta, Matías N. Möller, Beatriz Alvarez   +3 more
doaj   +1 more source

The Response of Acinetobacter baumannii to Hydrogen Sulfide Reveals Two Independent Persulfide-Sensing Systems and a Connection to Biofilm Regulation

mBio, 2020
Acinetobacter baumannii is an opportunistic nosocomial pathogen that is the causative agent of several serious infections in humans, including pneumonia, sepsis, and wound and burn infections. A.
Brenna J. C. Walsh, Jiefei Wang, Katherine A. Edmonds, Lauren D. Palmer, Yixiang Zhang, Jonathan C. Trinidad, Eric P. Skaar, David P. Giedroc   +7 more
doaj   +1 more source

Metabolic and Structural Insights into Hydrogen Sulfide Mis-Regulation in Enterococcus faecalis

Antioxidants, 2022
Hydrogen sulfide (H2S) is implicated as a cytoprotective agent that bacteria employ in response to host-induced stressors, such as oxidative stress and antibiotics.
Brenna J. C. Walsh, Sofia Soares Costa, Katherine A. Edmonds, Jonathan C. Trinidad, Federico M. Issoglio, José A. Brito, David P. Giedroc   +6 more
doaj   +1 more source

N-acetylcysteine serves as substrate of 3-mercaptopyruvate sulfurtransferase and stimulates sulfide metabolism in colon cancer cells [PDF]

, 2019
Hydrogen sulfide (H2S) is an endogenously produced signaling molecule. The enzymes 3-mercaptopyruvate sulfurtransferase (MST), partly localized in mitochondria, and the inner mitochondrial membrane-associated sulfide:quinone oxidoreductase (SQR), besides
Forte, Elena, Giardina, Giorgio, Giuffrè, Alessandro, Malagrinò, Francesca, Masi, Letizia, Paulini, Giulia, Tomé, Catarina S, Vicente, João B, Zuhra, Karim   +8 more
core   +2 more sources

Structures and functions of mitochondrial ABC transporters [PDF]

, 2015
A small number of physiologically important ATP-binding cassette (ABC) transporters are found in mitochondria. Most are half transporters of the B group forming homodimers and their topology suggests they function as exporters.
Aller, Ardehali, Balk, Bayeva, Belinda Faust, Bernard, Chen, Chen, Chen, Chitra A. Shintre, Chloupková, Christensen, Csere, Dawson, Dudek, Elisabeth P. Carpenter, Feissner, Giegé, Gompf, Graf, Gutmann, Hendrik W. van Veen, Higgins, Higgins, Hofacker, Hogue, Hyde, Ichikawa, Janneke Balk, Jin, Kessler, Kispal, Kispal, Kiss, Kiss, Krishnamurthy, Krüssel, Kuhnke, Kushnir, Lee, Leighton, Li, Liesa, Lill, Lill, Mikolay, Mitsuhashi, Paterson, Pondarré, Pondarré, Poor, Qi, Rayapuram, San Francisco, Schaedler, Senbongi, Shintre, Shirihai, Srinivasan, Teschner, Theresia A. Schaedler, Tiranti, Tsuchida, Vasundara Srinivasan, Ward, Yamamoto, Young, Zhang   +67 more
core   +2 more sources

Redox Signaling Regulated by Cysteine Persulfide and Protein Polysulfidation

Molecules, 2016
For decades, reactive persulfide species including cysteine persulfide (CysSSH) have been known to exist endogenously in organisms. However, the physiological significance of endogenous persulfides remains poorly understood. That cystathionine β-synthase
Shingo Kasamatsu, Akira Nishimura, Masanobu Morita, Tetsuro Matsunaga, Hisyam Abdul Hamid, Takaaki Akaike   +5 more
doaj   +1 more source

Transfer of Sulfur from IscS to IscU during Fe/S Cluster Assembly [PDF]

, 2001
The cysteine desulfurase enzymes NifS and IscS provide sulfur for the biosynthesis of Fe/S proteins. NifU and IscU have been proposed to serve as template or scaffold proteins in the initial Fe/S cluster assembly events, but the mechanism of sulfur ...
Hoff, Kevin G., Silberg, Jonathan J., Urbina, Hugo D., Vickery, Larry E.   +3 more
core   +1 more source

Mechanism of Iron–Sulfur Cluster Assembly: In the Intimacy of Iron and Sulfur Encounter

Inorganics, 2020
Iron–sulfur (Fe–S) clusters are protein cofactors of a multitude of enzymes performing essential biological functions. Specialized multi-protein machineries present in all types of organisms support their biosynthesis.
Batoul Srour, Sylvain Gervason, Beata Monfort, Benoit D’Autréaux   +3 more
doaj   +1 more source

Oral Administration of Glutathione Trisulfide Increases Reactive Sulfur Levels in Dorsal Root Ganglion and Ameliorates Paclitaxel-Induced Peripheral Neuropathy in Mice

Antioxidants, 2022
Peripheral neuropathy is a dose-limiting side effect of chemotherapy with paclitaxel. Paclitaxel-induced peripheral neuropathy (PIPN) is typically characterized by a predominantly sensory neuropathy presenting with allodynia, hyperalgesia and spontaneous
Mariko Ezaka, Eizo Marutani, Yusuke Miyazaki, Eiki Kanemaru, Martin K. Selig, Sophie L. Boerboom, Katrina F. Ostrom, Anat Stemmer-Rachamimov, Donald B. Bloch, Gary J. Brenner, Etsuo Ohshima, Fumito Ichinose   +11 more
doaj   +1 more source