Results 51 to 60 of about 4,338 (207)

Interaction of Staphylococcus aureus di-iron Repair of Iron Centers protein with the iron-sulfur cluster assembly SUF system. [PDF]

Protein Sci
Abstract Repair of Iron Centers (RIC) proteins are present in several pathogens, including Staphylococcus aureus, contributing to resistance to nitroxidative stress and virulence. In this work, we investigated the molecular mechanisms by which S. aureus RIC facilitates iron mobilization, through structural analyses and functional studies.
Lourenço FM, Silva LSO, Almeida MR, Folgosa F, Matias PM, Carvalho SM, Lima JC, Romão CV, Saraiva LM.   +8 more
europepmc   +2 more sources

Shared Sulfur Mobilization Routes for tRNA Thiolation and Molybdenum Cofactor Biosynthesis in Prokaryotes and Eukaryotes

Biomolecules, 2017
Modifications of transfer RNA (tRNA) have been shown to play critical roles in the biogenesis, metabolism, structural stability and function of RNA molecules, and the specific modifications of nucleobases with sulfur atoms in tRNA are present in pro- and
Silke Leimkühler, Martin Bühning, Lena Beilschmidt   +2 more
doaj   +1 more source

Cupriavidus pinatubonensis JMP134 Alleviates Sulfane Sulfur Toxicity after the Loss of Sulfane Dehydrogenase through Oxidation by Persulfide Dioxygenase and Hydrogen Sulfide Release

Metabolites, 2023
An incomplete Sox system lacking sulfane dehydrogenase SoxCD may produce and accumulate sulfane sulfur when oxidizing thiosulfate. However, how bacteria alleviate the pressure of sulfane sulfur accumulation remains largely unclear.
Yufeng Xin, Yaxin Wang, Honglin Zhang, Yu Wu, Yongzhen Xia, Huanjie Li, Xiaohua Qu   +6 more
doaj   +1 more source

Sulfide Homeostasis and Nitroxyl Intersect via Formation of Reactive Sulfur Species in Staphylococcus aureus

mSphere, 2017
Staphylococcus aureus is a commensal human pathogen and a major cause of nosocomial infections. As gaseous signaling molecules, endogenous hydrogen sulfide (H2S) and nitric oxide (NO·) protect S.
Hui Peng, Jiangchuan Shen, Katherine A. Edmonds, Justin L. Luebke, Anne K. Hickey, Lauren D. Palmer, Feng-Ming James Chang, Kevin A. Bruce, Thomas E. Kehl-Fie, Eric P. Skaar, David P. Giedroc   +10 more
doaj   +1 more source

Is Endothelial Nitric Oxide Synthase a Moonlighting Protein Whose Day Job is Cholesterol Sulfate Synthesis? Implications for Cholesterol Transport, Diabetes and Cardiovascular Disease [PDF]

, 2012
Theoretical inferences, based on biophysical, biochemical, and biosemiotic considerations, are related here to the pathogenesis of cardiovascular disease, diabetes, and other degenerative conditions.
Ali, Ann Lauritzen, Billecke, Brune, Cignarelli, Cordelier, Deniziak, Dimmeler, Drayer, Gajkowska, Girard, Gross, Hao, Hart, Ho, Hopwood, Hopwood, Ignarro, Jagger, Jakubowski, Joensuu, Laurie Lentz-Marino, McCully, Nakae, Pfennig, Pollack, Randriamboavonjy, Rearick, Robert Davidson, Seidel, Stephanie Seneff, Suzuki, Tedder, Teske, Tsai, Voeikov   +35 more
core   +4 more sources

Persulfide Biosynthesis Conserved Evolutionarily in All Organisms

Antioxidants & Redox Signaling, 2023
Significance: Persulfides/polysulfides are sulfur-catenated molecular species (i.e., R-Sn-R', n > 2; R-Sn-H, n > 1, with R = cysteine, glutathione, and proteins), such as cysteine persulfide (CysSSH). These species are abundantly formed as endogenous metabolites in mammalian and human cells and tissues.
Seiryo Ogata, Tetsuro Matsunaga, Minkyung Jung, Uladzimir Barayeu, Masanobu Morita, Takaaki Akaike   +5 more
openaire   +2 more sources

Rhodaneses minimize the accumulation of cellular sulfane sulfur to avoid disulfide stress during sulfide oxidation in bacteria

Redox Biology, 2022
Heterotrophic bacteria and human mitochondria often use sulfide: quinone oxidoreductase (SQR) and persulfide dioxygenase (PDO) to oxidize sulfide to sulfite and thiosulfate.
Mingxue Ran, Qingbin Li, Yufeng Xin, Shaohua Ma, Rui Zhao, Min Wang, Luying Xun, Yongzhen Xia   +7 more
doaj   +1 more source

Conformational studies on Arabidopsis sulfurtransferase AtStr1 with spectroscopic methods [PDF]

, 2007
Sulfurtransferases/rhodaneses (Str) are enzymes widely distributed in archaea, prokaryota and eukaryota, and catalyze the transfer of sulfur from a donor molecule to a thiophilic acceptor substrate.
Bartels, Andrea, Forlani, Fabio, Pagani, Silvia, Papenbrock, Jutta   +3 more
core   +2 more sources

Iron–sulfur clusters: from metals through mitochondria biogenesis to disease [PDF]

, 2018
Iron–sulfur clusters are ubiquitous inorganic co-factors that contribute to a wide range of cell pathways including the maintenance of DNA integrity, regulation of gene expression and protein translation, energy production, and antiviral response ...
Cardenas-Rodriguez, Mauricio, Chatzi, Afroditi, Tokatlidis, Kostas   +2 more
core   +1 more source

Sulfur metabolic response in macrophage limits excessive inflammatory response by creating a negative feedback loop

Redox Biology, 2023
The excessive inflammatory response of macrophages plays a vital role in the pathogenesis of various diseases. The dynamic metabolic alterations in macrophages, including amino acid metabolism, are known to orchestrate their inflammatory phenotype.
Haruna Takeda, Shohei Murakami, Zun Liu, Tomohiro Sawa, Masatomo Takahashi, Yoshihiro Izumi, Takeshi Bamba, Hideyo Sato, Takaaki Akaike, Hiroki Sekine, Hozumi Motohashi   +10 more
doaj   +1 more source