Results 71 to 80 of about 1,224 (162)

Characterization of redox-active cysteine residues of persulfide-responsive transcriptional repressor SqrR

Communicative & Integrative Biology, 2017
We recently identified the novel persulfide sensor SqrR that functions as a master regulator of sulfide-dependent gene expression in the purple photosynthetic bacterium Rhodobacter capsulatus. SqrR binds to the promoter regions of target genes to repress
Takayuki Shimizu, Shinji Masuda
doaj   +1 more source

Thioglucose-derived tetrasulfide, a unique polysulfide model compound

Redox Biology
Polysulfides have received increased interest in redox biology due to their role as the precursors of H2S and persulfides. However, the compounds that are suitable for biological investigations are limited to cysteine- and glutathione-derived ...
Stephen Lindahl, Meg Shieh, Tianli Zhang, Chunyu Guo, Jerome R. Robinson, Tomohiro Sawa, Ming Xian   +6 more
doaj   +1 more source

Polysulfides promote ATF6 oligomerization via persulfidation to modulate ER stress responses

Redox Biochemistry and Chemistry
ATF6 is a UPR sensor regulated by redox modification of luminal cysteine residues. Although polysulfides modulate proteins through cysteine persulfidation, their effect on ATF6 has been unclear.
Shin Koike, Norihiro Shibuya, Yuki Ogasawara   +2 more
doaj   +1 more source

Self-S-sulfonation in a bacterial persulfide dioxygenase mediates thiol persulfide detoxification

A ubiquitous class of non-heme Fe(II) enzymes, the persulfide dioxygenases (PDOs), provide protection against hydrogen sulfide (H2S) poisoning. The PDO in humans is a single-domain enzyme, while bacterial PDOs, such as CstB of Staphylococcus aureus, are often fused to a sulfurtransferase (rhodanese) module.
Julius O. Campecino, Sofia S. Costa, Brenna J.C. Walsh, Jonathan C. Trinidad, Jyoti Kannoujia, Andrew T. Poor, Casey M. Van Stappen, Giovanni Gonzalez-Gutierrez, Margarida Archer, Jose A. Brito, David P. Giedroc   +10 more
openaire   +2 more sources

N-Acetylcysteine Serves as Substrate of 3-Mercaptopyruvate Sulfurtransferase and Stimulates Sulfide Metabolism in Colon Cancer Cells

Cells, 2019
Hydrogen sulfide (H2S) is an endogenously produced signaling molecule. The enzymes 3-mercaptopyruvate sulfurtransferase (MST), partly localized in mitochondria, and the inner mitochondrial membrane-associated sulfide:quinone oxidoreductase (SQR), besides
Karim Zuhra, Catarina S. Tomé, Letizia Masi, Giorgio Giardina, Giulia Paulini, Francesca Malagrinò, Elena Forte, João B. Vicente, Alessandro Giuffrè   +8 more
doaj   +1 more source

Polysulfide Na2S4 regulates the activation of PTEN/Akt/CREB signaling and cytotoxicity mediated by 1,4-naphthoquinone through formation of sulfur adducts

Scientific Reports, 2017
Electrophiles can activate redox signal transduction pathways, through actions of effector molecules (e.g., kinases and transcription factors) and sensor proteins with low pKa thiols that are covalently modified.
Yumi Abiko, Yasuhiro Shinkai, Takamitsu Unoki, Reiko Hirose, Takashi Uehara, Yoshito Kumagai   +5 more
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The Role of Persulfide Metabolism During Arabidopsis Seed Development Under Light and Dark Conditions

Frontiers in Plant Science, 2018
The sulfur dioxygenase ETHE1 oxidizes persulfides in the mitochondrial matrix and is involved in the degradation of L-cysteine and hydrogen sulfide. ETHE1 has an essential but as yet undefined function in early embryo development of Arabidopsis thaliana.
Christin Lorenz, Saskia Brandt, Ljudmilla Borisjuk, Hardy Rolletschek, Nicolas Heinzel, Takayuki Tohge, Alisdair R. Fernie, Hans-Peter Braun, Tatjana M. Hildebrandt   +8 more
doaj   +1 more source

Ascorbate Recycling as a Molecular Redox Capacitor: A Sulfur-Centered Perspective on Dehydroascorbate Reduction in Biological Systems

Cells
Ascorbate (AsA), or vitamin C, is a central redox metabolite that functions as an antioxidant, enzyme cofactor, and electron donor. Its cellular function depends not only on biosynthesis or dietary uptake, but also on rapid recycling from its oxidized ...
Rika Heshiki, Kakeru B. Mizumoto, Riko F. Naomasa, Takashi Matsumura, Hideo Yamasaki   +4 more
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Sulfide Homeostasis and Nitroxyl Intersect via Formation of Reactive Sulfur Species in Staphylococcus aureus

mSphere, 2017
Staphylococcus aureus is a commensal human pathogen and a major cause of nosocomial infections. As gaseous signaling molecules, endogenous hydrogen sulfide (H2S) and nitric oxide (NO·) protect S.
Hui Peng, Jiangchuan Shen, Katherine A. Edmonds, Justin L. Luebke, Anne K. Hickey, Lauren D. Palmer, Feng-Ming James Chang, Kevin A. Bruce, Thomas E. Kehl-Fie, Eric P. Skaar, David P. Giedroc   +10 more
doaj   +1 more source

2H-Thiopyran-2-thione sulfine, a compound for converting H2S to HSOH/H2S2 and increasing intracellular sulfane sulfur levels

Nature Communications
Reactive sulfane sulfur species such as persulfides (RSSH) and H2S2 are important redox regulators and closely linked to H2S signaling. However, the study of these species is still challenging due to their instability, high reactivity, and the lack of ...
Qi Cui, Meg Shieh, Tony W. Pan, Akiyuki Nishimura, Tetsuro Matsunaga, Shane S. Kelly, Shi Xu, Minkyung Jung, Seiryo Ogata, Masanobu Morita, Jun Yoshitake, Xiaoyan Chen, Jerome R. Robinson, Wei-Jun Qian, Motohiro Nishida, Takaaki Akaike, Ming Xian   +16 more
doaj   +1 more source