Results 81 to 90 of about 1,976 (189)

Antioxidative and anti-inflammatory actions of reactive cysteine persulfides

Journal of Clinical Biochemistry and Nutrition, 2021
Cysteine persulfide (CysSSH) and polysulfides (CysS[S] n H, n>1) are cysteine derivatives having sulfane sulfur atoms bound to cysteine thiol. Recent advances in the development of analytical methods for detection and quantification of persulfides and polysulfides have revealed the biological presence, in both prokaryotes and eukaryotes, of persulfide ...
Zhang, Tianli, Tsutsuki, Hiroyasu, Ono, Katushiko, Akaike, Takaaki, Sawa, Tomohiro   +4 more
openaire   +3 more sources

Fluorescent probes for hydrogen sulfide detection and bioimaging [PDF]

, 2014
In comparison with other biological detection technologies, fluorescence bioimaging technology has become a powerful supporting tool for intracellular detection, and can provide attractive facilities for investigating physiological and pathological ...
Chen, Lingxin, Chen, LX (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Res Ctr Coastal Environm Engn & Technol Shandong, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China. lxchen@yic.ac.cn, Han, Xiaoyue, Yu, Fabiao   +3 more
core   +1 more source

Interaction of Staphylococcus aureus di‐iron Repair of Iron Centers protein with the iron–sulfur cluster assembly SUF system

Protein Science, Volume 35, Issue 1, January 2026.
Abstract Repair of Iron Centers (RIC) proteins are present in several pathogens, including Staphylococcus aureus, contributing to resistance to nitroxidative stress and virulence. In this work, we investigated the molecular mechanisms by which S. aureus RIC facilitates iron mobilization, through structural analyses and functional studies.
Frederico M. Lourenço, Liliana S. O. Silva, Mafalda R. Almeida, Filipe Folgosa, Pedro M. Matias, Sandra M. Carvalho, João C. Lima, Célia V. Romão, Lígia M. Saraiva   +8 more
wiley   +1 more source

NRF2 signalling in cytoprotection and metabolism

British Journal of Pharmacology, Volume 183, Issue 1, Page 101-114, January 2026.
The KEAP1‐NRF2 system plays a central role in cytoprotection in defence mechanisms against oxidative stress. The KEAP1‐NRF2 system has been regarded as a sulfur‐utilizing cytoprotective mechanism, because KEAP1 serves as a biosensor for electrophiles by using its reactive thiols and NRF2 is a transcriptional factor regulating genes involved in sulfur ...
Shohei Murakami, Yusuke Kusano, Keito Okazaki, Takaaki Akaike, Hozumi Motohashi   +4 more
wiley   +1 more source

Mining proteomes for zinc finger persulfidation

RSC Chemical Biology
A meta-analysis of 22 persulfide-specific proteomics datasets reveals widespread persulfidation of zinc finger proteins across various species, highlighting the role of persulfidation as an important post-translational modification.
Haoju Li, Andrew T. Stoltzfus, Sarah L. J. Michel   +2 more
openaire   +2 more sources

Characterization of redox-active cysteine residues of persulfide-responsive transcriptional repressor SqrR

Communicative & Integrative Biology, 2017
We recently identified the novel persulfide sensor SqrR that functions as a master regulator of sulfide-dependent gene expression in the purple photosynthetic bacterium Rhodobacter capsulatus. SqrR binds to the promoter regions of target genes to repress
Takayuki Shimizu, Shinji Masuda
doaj   +1 more source

Supersulfide biology and translational medicine for disease control

British Journal of Pharmacology, Volume 183, Issue 1, Page 115-130, January 2026.
Abstract For decades, the major focus of redox biology has been oxygen, the most abundant element on Earth. Molecular oxygen functions as the final electron acceptor in the mitochondrial respiratory chain, contributing to energy production in aerobic organisms. In addition, oxygen‐derived reactive oxygen species including hydrogen peroxide and nitrogen
Uladzimir Barayeu, Tomohiro Sawa, Motohiro Nishida, Fan‐Yan Wei, Hozumi Motohashi, Takaaki Akaike   +5 more
wiley   +1 more source

Biosynthesis and Reactivity of Cysteine Persulfides in Signaling [PDF]

Journal of the American Chemical Society, 2015
Hydrogen sulfide (H2S) elicits pleiotropic physiological effects ranging from modulation of cardiovascular to CNS functions. A dominant method for transmission of sulfide-based signals is via posttranslational modification of reactive cysteine thiols to persulfides. However, the source of the persulfide donor and whether its relationship to H2S is as a
Pramod K, Yadav, Michael, Martinov, Victor, Vitvitsky, Javier, Seravalli, Rudolf, Wedmann, Milos R, Filipovic, Ruma, Banerjee   +6 more
openaire   +2 more sources

Polysulfide Na2S4 regulates the activation of PTEN/Akt/CREB signaling and cytotoxicity mediated by 1,4-naphthoquinone through formation of sulfur adducts

Scientific Reports, 2017
Electrophiles can activate redox signal transduction pathways, through actions of effector molecules (e.g., kinases and transcription factors) and sensor proteins with low pKa thiols that are covalently modified.
Yumi Abiko, Yasuhiro Shinkai, Takamitsu Unoki, Reiko Hirose, Takashi Uehara, Yoshito Kumagai   +5 more
doaj   +1 more source

Nitrosopersulfide (SSNO(-)) targets the Keap-1/Nrf2 redox system.

Nitric oxide (NO), hydrogen sulfide and polysulfides have been proposed to contribute to redox signaling by activating the Keap-1/Nrf2 stress response system. Nitrosopersulfide (SSNO(-)) recently emerged as a bioactive product of the chemical interaction
Cortese-Krott, Miriam M., Feelisch, Martin, Pullmann, David   +2 more
core   +1 more source