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Bordetella parapertussis isolates not expressing pertactin circulating in France [PDF]
Clinical Microbiology and Infection, 2011 Surprisingly, most Bordetella parapertussis isolates collected in France since 2007 do not express pertactin, owing to mutations in the structural gene encoding this protein.
N Guiso
exaly +4 more sources
Role of the Bordetella pertussis P.69/pertactin protein and the P.69/pertactin RGD motif in the adherence to and invasion of mammalian cells [PDF]
Microbiology (United Kingdom), 1996 The role of the Bordetella pertussis P.69/pertactin protein in mammalian cell adhesion and invasion was investigated. Salmonella strains expressing surface-associated P.69/pertactin from a chromosomally located prn gene were significantly more invasive ...
Jingli Li, G Douce, Joyce De Azavedo
exaly +4 more sources
Journal of Molecular Biology, 1994 Pertactin, a membrane-associated protein of Bordetella pertussis, has been crystallized in the presence of 28% ammonium sulphate. The space group is P6(3)22 with cell dimensions a = b = 178.2 A and c = 106.8 A.
Gerry Mcdermott +2 more
exaly +4 more sources
Vaccine, 1992 The immunogenicity of recombinant (r-) pertactin was examined. Parenteral immunization of mice with natural or r-pertactin produced a similar increase in serum anti-pertactin antibodies and a decrease in Bordetella pertussis lung counts following aerosol
J P Tite, Gordon Dougan, I G Charles
exaly +2 more sources
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Comparison of recombinant and native pertactin of Bordetella pertussis
Vaccine, 2011Bordetella pertussis pertactin (Prn) is an important attachment factor and protective immunogen, which serves as a component in most acellular pertussis vaccines (APVs). Here, we over-expressed recombinant Prn (r-Prn) without an affinity tag using an Escherichia coli expression system. Compared to the native Prn (n-Prn) from B.
Yinghua Xu, Yajun Tan, Dorothy Xing
exaly +3 more sources
Vaccine, 1991 Acellular whooping cough vaccines are based on pertussis toxoid but their effectiveness may be increased by the addition of other Bordetella pertussis antigens. We expressed the immunogenic outer membrane protein pertactin (P69) from B. pertussis to high
Michael A Romanos +2 more
exaly +2 more sources
Pediatric Infectious Disease Journal, 2017
Resurgence of Bordetella pertussis in recent years in the United States has coincided with a dramatic rise in pertactin-deficient strains. Limited data exist on detectability by nucleic acid amplification testing and antimicrobial susceptibility of pertactin-deficient B. pertussis. This study compares 15 pertactin-producing and 15 pertactin-deficient B.
Emily, Souder +3 more
openaire +2 more sources
Resurgence of Bordetella pertussis in recent years in the United States has coincided with a dramatic rise in pertactin-deficient strains. Limited data exist on detectability by nucleic acid amplification testing and antimicrobial susceptibility of pertactin-deficient B. pertussis. This study compares 15 pertactin-producing and 15 pertactin-deficient B.
Emily, Souder +3 more
openaire +2 more sources
Vaccine, 2009 International audienceBordetella pertussis isolates not expressing Pertussis Toxin (PT) or Pertactin (PRN) have been collected, for the first time in 2007, in France, a highly vaccinated country with acellular vaccines. Non-expression was due to deletion
Nicole Guiso
exaly +2 more sources
Pertussis Vaccine Effectiveness in the Setting of Pertactin-Deficient Pertussis
Pediatrics, 2016BACKGROUND:In the United States, the proportion of Bordetella pertussis isolates lacking pertactin, a component of acellular pertussis vaccines, increased from 14% in 2010 to 85% in 2012. The impact on vaccine effectiveness (VE) is unknown.METHODS:We conducted 2 matched case-control evaluations in Vermont to assess VE of the 5-dose diphtheria, tetanus,
Lucy, Breakwell +7 more
openaire +2 more sources