Results 171 to 180 of about 3,408 (187)

A novel outer membrane vesicle adjuvant improves vaccine protection against Bordetella pertussis. [PDF]

NPJ Vaccines
Galeas-Pena M, Hirsch A, Kuang E, Hoffmann J, Gellings P, Brown JB, Limbert VM, Callahan CL, McLachlan JB, Morici LA.   +9 more
europepmc   +1 more source

Emergence of Bordetella holmesii-Associated Pertussis-Like Illness, Northern India, 2019-2023. [PDF]

Emerg Infect Dis
Shekhar N, Sharma D, Chakraborty S, Kumar R, Rawat RS, Kaundal N, Kumar P, Avagyan T, Chauhan D, Jain N, Sharma M, Kumar A, Gautam V.   +12 more
europepmc   +1 more source

An Evaluation of the Safety, Immunogenicity, and Protective Efficacy of a Combined Diphtheria-Tetanus-Acellular Pertussis, <i>Haemophilus influenzae</i> Type b, and ACYW135 Meningococcal Conjugate Vaccine in Murine and Rat Models. [PDF]

Vaccines (Basel)
Sui X, Shao Z, Ji Y, Wang H, Xu Q, Wei B, Duan Z, Wang C, Yang Y, Zhao J, Zhu T.   +10 more
europepmc   +1 more source

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Antimicrobial Susceptibility and Molecular Detection of Pertactin-producing and Pertactin-Deficient Bordetella pertussis

Pediatric Infectious Disease Journal, 2017
Resurgence of Bordetella pertussis in recent years in the United States has coincided with a dramatic rise in pertactin-deficient strains. Limited data exist on detectability by nucleic acid amplification testing and antimicrobial susceptibility of pertactin-deficient B. pertussis. This study compares 15 pertactin-producing and 15 pertactin-deficient B.
Emily, Souder, Jennifer, Vodzak, Alan T, Evangelista, Sarah S, Long   +3 more
openaire   +2 more sources

Hybrid genes over-express pertactin from Bordetella pertussis

Vaccine, 1995
Pertactin is a surface adhesin of Bordetella pertussis which is produced in small quantities when expressed from the native prn promoter. Hybrid genes were constructed in which the prn promoter was replaced by either the fha or tox promoter. Recombinant B.
S M, Loosmore, R K, Yacoob, G R, Zealey, G E, Jackson, Y P, Yang, P S, Chong, J M, Shortreed, D C, Coleman, J D, Cunningham, L, Gisonni   +9 more
openaire   +2 more sources

Comparison of recombinant and native pertactin of Bordetella pertussis

Vaccine, 2011
Bordetella pertussis pertactin (Prn) is an important attachment factor and protective immunogen, which serves as a component in most acellular pertussis vaccines (APVs). Here, we over-expressed recombinant Prn (r-Prn) without an affinity tag using an Escherichia coli expression system. Compared to the native Prn (n-Prn) from B.
Yinghua, Xu, Shumin, Zhang, Barbara, Bolgiano, Yajun, Tan, Cathy, Asokanathan, Huajie, Zhang, Dorothy, Xing, Junzhi, Wang   +7 more
openaire   +2 more sources

Structure of Bordetella pertussis virulence factor P.69 pertactin

Nature, 1996
A new generation of whooping-cough vaccines contain P.69 pertactin, a surface-exposed domain of an outer membrane protein expressed by the virulent bacterium Bordetella pertussis. This protein is a virulence factor that mediates adhesion to target mammalian cells, a reaction that is in part mediated by an RGD sequence.
P, Emsley, I G, Charles, N F, Fairweather, N W, Isaacs   +3 more
openaire   +2 more sources

Pertussis Vaccine Effectiveness in the Setting of Pertactin-Deficient Pertussis

Pediatrics, 2016
BACKGROUND:In the United States, the proportion of Bordetella pertussis isolates lacking pertactin, a component of acellular pertussis vaccines, increased from 14% in 2010 to 85% in 2012. The impact on vaccine effectiveness (VE) is unknown.METHODS:We conducted 2 matched case-control evaluations in Vermont to assess VE of the 5-dose diphtheria, tetanus,
Lucy, Breakwell, Patsy, Kelso, Christine, Finley, Susan, Schoenfeld, Brant, Goode, Lara K, Misegades, Stacey W, Martin, Anna M, Acosta   +7 more
openaire   +2 more sources

Novel mouse monoclonal antibodies against Bordetella pertussis pertactin antigen with versatile applications

Journal of Microbiological Methods, 2023
Pertussis, or whooping cough, is a highly contagious respiratory disease caused by Bordetella pertussis (BP). Pertactin (PRN) is one of the main immunogenic components of BP and is employed in many commercialized acellular pertussis vaccines (aPVs). Purification of this protein by conventional chromatography methods is challenging and commonly requires
Danyal, Imani, Tannaz, Bahadori, Sedighe, Ghourchian, Forough, Golsaz-Shirazi, Masoumeh, Douraghi, Mahmood, Jeddi-Tehrani, Mohammad Mehdi, Amiri, Fazel, Shokri   +7 more
openaire   +2 more sources