Results 11 to 20 of about 51,251 (208)
Alpha-1 antitrypsin inhibits pertussis toxin. [PDF]
J Biol ChemPertussis (whooping cough) is a vaccine-preventable but re-emerging, highly infectious respiratory disease caused by Bordetella pertussis. There are currently no effective treatments for pertussis, complicating care for nonvaccinated individuals, especially newborns.
Lietz S +20 more
europepmc +3 more sources
Mechanisms of Pertussis Toxin Action: ADP-Ribosylation and Its Role in Pertussis Pathogenesis [PDF]
ToxinsPertussis toxin (PTx) is a major virulence factor of Bordetella pertussis and an AB5-type exotoxin that disrupts host signaling. Its enzymatic A subunit ADP-ribosylates the α-subunit of inhibitory G proteins (Gαi), preventing them from mediating receptor-
Qing Tang +3 more
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The crystal structure of pertussis toxin [PDF]
Structure, 1994 Pertussis toxin is an exotoxin of the A-B class produced by Bordetella pertussis. The holotoxin comprises 952 residues forming six subunits (five different sequences, S1-S5). It plays an important role in the development of protective immunity to whooping cough, and is an essential component of new acellular vaccines.
P E, Stein +5 more
openaire +4 more sources
Vaccines, 2021 Pertussis is an acute respiratory tract infection caused by Bordetella pertussis. Even though its current vaccine coverage is relatively broad, they still have some shortcomings such as short protection time and might be incapable of blocking the spread ...
Han Xu +10 more
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New combination of methods for isolation and purification of pertussis toxin from the Bordetella pertussis culture [PDF]
Hemijska Industrija, 2011 In this paper a method for isolation and purification of the pertussis toxin from the cell culture of Bordetella pertussis was presented. Pertussis toxin production was enhanced with the optimization of the microbiological media and cultivation time ...
Pavlović Katarina B. +1 more
doaj +1 more source
Pertussis toxin neutralizing antibody response after an acellular booster vaccination in Dutch and Finnish participants of different age groups. [PDF]
Emerg Microbes Infect, 2022 Knuutila A +7 more
europepmc +2 more sources
mBio, 2020 Dermonecrotic toxin (DNT) is one of the representative toxins produced by Bordetella pertussis, but its role in pertussis, B. pertussis infection, remains unknown.
Shihono Teruya +13 more
doaj +1 more source
Toxins, 2021 The antigens for acellular pertussis vaccines are made up of protein components that are purified directly from Bordetella pertussis (B. pertussis) bacterial fermentation. As such, there are additional B.
Lisa Szymkowicz +4 more
doaj +1 more source
Evaluation of Pertussis Toxin Expression in B2 and THIJS Media [PDF]
Archives of Razi Institute, 2019 Whole-cell pertussis vaccine (wP) has been imperative and highly effective in preventing childhood deaths due to pertussis. Pertussis toxin is one of the virulence factors of Bordetella pertussis in all available pertussis vaccines. wP production in Razi
H. Moradtalab +3 more
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Неонатологія, хірургія та перинатальна медицина, 2023 Coronavirus disease remains one of the most serious diseases in the world. The percentage of severe and fatal cases in children is lower than in adults. The search for biomarkers of disease severity continues.
Г. Павлишин +2 more
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