Results 21 to 30 of about 29,628 (214)
Genetics of pertussis toxin [PDF]
Molecular Microbiology, 1989 SummaryPertussis toxin (PT) is the major virulence factor of Bordetella pertussis. The cloning and nucleotide sequencing of the PT genes from B. pertussis, Bordetella parapertussis and Bordetella bronchiseptica has elucidated the evolution of the Bordetella species and allowed considerable advances towards the understanding of their gene expression and
R, Gross, B, Aricò, R, Rappuoli
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PLoS Pathogens, 2022 Pulmonary infections caused by Bordetella pertussis used to be the prime cause of infant mortality in the pre-vaccine era and mouse models of pertussis pneumonia served in characterization of B. pertussis virulence mechanisms.
Jana Holubova +5 more
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Promoter of the pertussis toxin operon and production of pertussis toxin [PDF]
Journal of Bacteriology, 1987 Pertussis toxin (PT), the major virulence factor of Bordetella pertussis, is composed of five different subunits whose genes are organized as an operon. We report the mapping of the promoter region of the PT operon and show that this promoter is only weakly active in Escherichia coli. Bordetella parapertussis and Bordetella bronchiseptica, which do not
NICOSIA, Alfredo, R. RAPPUOLI
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Human Vaccines & Immunotherapeutics, 2019 Pertussis is resurgent worldwide. Currently available acellular pertussis vaccines contain chemically detoxified pertussis toxin (PTc); a highly immunogenic genetically detoxified pertussis toxin (PTg) vaccine has been off the market for over a decade ...
Naveen Surendran, Michael Pichichero
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BMC Medicine, 2021 Background Pertussis vaccines containing three or five pertussis antigens are recommended in pregnancy in many countries, but no studies have compared the effect on infants’ antigen-specific immunoglobulin G (IgG) concentrations.
Christine Elizabeth Jones +10 more
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PTX Instructs the Development of Lung-Resident Memory T Cells in Bordetella pertussis Infected Mice
Toxins, 2021 Whooping cough is a severe, highly contagious disease of the human respiratory tract, caused by Bordetellapertussis. The pathogenicity requires several virulence factors, including pertussis toxin (PTX), a key component of current available vaccines ...
Julie Tomas +6 more
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Эпидемиология и вакцинопрофилактика, 2017 Goal. Study of the protective activity and safety of acellular pertussis vaccine (APV) using freshly isolated strain of B. pertussis. Materials and methods. Mice-hybrids F1 (CBAxC57Bl6). The B. pertussis strains: vaccine strains No. 305, No. 203, freshly
E. M. Zaitsev +2 more
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Differentially expressed genes in Bordetella pertussis strains belonging to a lineage which recently spread globally. [PDF]
PLoS ONE, 2014 Pertussis is a highly contagious, acute respiratory disease in humans caused by the Gram-negative pathogen Bordetella pertussis. Pertussis has resurged in the face of intensive vaccination and this has coincided with the emergence of strains carrying a ...
Daan de Gouw +6 more
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G(i)-coupled GPCR signaling controls the formation and organization of human pluripotent colonies. [PDF]
PLoS ONE, 2009 BACKGROUND:Reprogramming adult human somatic cells to create human induced pluripotent stem (hiPS) cell colonies involves a dramatic morphological and organizational transition.
Kenta Nakamura +4 more
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Frontiers in Microbiology, 2023 Pertussis, commonly known as whooping cough is a severe respiratory disease caused by the bacterium, Bordetella pertussis. Despite widespread vaccination, pertussis resurgence has been observed globally.
Hiroki Suyama +4 more
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