Results 81 to 90 of about 29,628 (214)

Molecular cloning of pertussis toxin genes

Nucleic Acids Research, 1986
We have cloned a 4.5 kb EcoRI/BamHI DNA fragment from Bordetella pertussis which contains at least two genes responsible for expression of pertussis toxin. The S4 subunit of the toxin was isolated by high pressure liquid chromatography and the NH2-terminal amino acid sequence determined. Using a mixed synthetic oligonucleotide probe designed by reverse
C, Locht, P A, Barstad, J E, Coligan, L, Mayer, J J, Munoz, S G, Smith, J M, Keith   +6 more
openaire   +3 more sources

Pertussis Toxin or Antigen

Experimental Biology and Medicine, 1933
Mishulow, Mowry and Scott1 demonstrated that exotoxic filtrates could be obtained from whooping cough cultures. They planted their organisms on chocolate agar over which they had poured a small amount of horse serum-beef heart broth. The small amount of diluent made the harvest of toxin necessarily small. On the other hand, Craster and Smith2 mentioned
J. A. Toomey, J. E. McClelland
openaire   +1 more source

Bordetella Adenylate Cyclase Toxin Inhibits Monocyte-to-Macrophage Transition and Dedifferentiates Human Alveolar Macrophages into Monocyte-like Cells

mBio, 2019
Monocytes arriving at the site of infection differentiate into functional effector macrophages to replenish the resident sentinel cells. Bordetella pertussis, the pertussis agent, secretes an adenylate cyclase toxin-hemolysin (CyaA) that binds myeloid ...
Jawid Nazir Ahmad, Jana Holubova, Oldrich Benada, Olga Kofronova, Ludek Stehlik, Martina Vasakova, Peter Sebo   +6 more
doaj   +1 more source

Bordetella pertussis infection exacerbates influenza virus infection through pertussis toxin-mediated suppression of innate immunity.

PLoS ONE, 2011
Pertussis (whooping cough) is frequently complicated by concomitant infections with respiratory viruses. Here we report the effect of Bordetella pertussis infection on subsequent influenza virus (PR8) infection in mouse models and the role of pertussis ...
Victor I Ayala, John R Teijaro, Donna L Farber, Susan G Dorsey, Nicholas H Carbonetti   +4 more
doaj   +1 more source

The inhibition by pertussis and tetanus toxins of evoked catecholamine release from intact and permeabilized bovine adrenal chromaffin cells [PDF]

, 1990
Mohinder K. Bansal, John H. Phillips, Simon van Heyningen   +2 more
openalex   +1 more source

Role ofBordetella pertussisRseA in the cell envelope stress response and adenylate cyclase toxin release [PDF]

, 2013
Tomoko Hanawa, Hideo Yonezawa, Hayato Kawakami, Shigeru Kamiya, Sandra K. Armstrong   +4 more
openalex   +1 more source

Prevention of pertussis: An unresolved problem

Human Vaccines & Immunotherapeutics, 2018
Pertussis is a highly contagious respiratory disease caused by Bordetella pertussis. However, after the introduction of the whole-cell pertussis vaccine (wP), the annual incidence rates of the disease progressively declined.
Susanna Esposito, Nicola Principi
doaj   +1 more source

Involvement of Cyclic Adenosine Monophosphate-Dependent Protein Kinase A and Pertussis Toxin-Sensitive G Proteins in the Migratory Response of Human CD14+ Mononuclear Cells to Katacalcin [PDF]

, 2002
Nicole C. Kaneider, Petra Egger, Franz J. Wiedermann, Markus Ritter, Ewald Wöll, Christian J. Wiedermann   +5 more
openalex   +1 more source

Seroprevalence of IgA and IgM antibodies to Bordetella pertussis in healthy Japanese donors: Assessment for the serological diagnosis of pertussis.

PLoS ONE, 2019
Pertussis is a human respiratory infection caused by the gram-negative bacterium, Bordetella pertussis. To evaluate the pertussis burden and vaccine efficacy, diagnosis and epidemiological surveillance should be based on accurate and valid diagnostic ...
Rei Fumimoto, Nao Otsuka, Hajime Kamiya, Tomimasa Sunagawa, Keiko Tanaka-Taya, Kazunari Kamachi, Keigo Shibayama   +6 more
doaj   +1 more source

Antibody avidity to pertussis toxin after acellular pertussis vaccination and infection. [PDF]

Emerg Microbes Infect, 2023
Knuutila A, Dalby T, Ahvenainen N, Barkoff AM, Jørgensen CS, Fuursted K, Mertsola J, He Q.   +7 more
europepmc   +1 more source