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Development of sensitive methods for detection of porcine endogenous retrovirus-C (PERV-C) in the genome of pigs [PDF]

Journal of Virological Methods, 2011
Porcine endogenous retroviruses (PERV) represent a risk for xenotransplantation using pig cells, tissues or organs. PERV-A and PERV-B are present in the genome of all pigs and both infect human cells in vitro. PERV-C infects only pig cells and it is integrated in the genome of most, but not all pigs.
Björn Petersen, Ralf R Tönjes, Joachim Denner   +2 more
exaly   +4 more sources

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Improved pig donor screening including newly identified variants of porcine endogenous retrovirus-C (PERV-C)

Archives of Virology, 2012
Porcine endogenous retroviruses (PERV) are widely distributed in the genomes of pigs. PERV-A and PERV-B are present in all pigs. They infect human cells in vitro and therefore represent a risk for xenotransplantation when pig cells, tissues or organs are used. PERV-C infects only pig cells and is not present in the genomes of all pigs.
Cornelia Adlhoch, Joachim Denner
exaly   +3 more sources

Cloning and characterization of replication‐competent ecotropic porcine endogenous retroviruses (PERV‐C) in the genome of pigs used and intended for clinical pig‐to‐human xenotransplantation

Xenotransplantation, 2014
Porcine endogenous retroviruses (PERV) pose a xenozoonotic risk when applying pig organs, tissues and cells in clinical xenotransplantation. Three classes of replication‐competent PERV were described in host range and interference studies [1]. Polytropic PERV‐A and PERV‐B are able to infect not only human cells but also various cell lines in vitro ...
Michael Rodrigues Costa, Nicole Fischer, Barbara Gulich, Hanna Belschner, Antonia Gronewold, Ralf R. Tönjes   +5 more
openaire   +1 more source

412.3: Analysis of PERV-C superinfection resistance using HA-tagged viruses

Transplantation, 2023
Merle Flecks, Ralf R. Tönjes, Antonia W. Godehardt   +2 more
openaire   +1 more source

301.2: Isolation and functional analysis of an ecotropic porcine endogenous retrovirus PERV-C from a Yucatan SLA D/D haplotype inbred miniature swine

Transplantation, 2023
Michael Rodrigues Costa, Nicole Fischer, Antonia Gronewold, Barbara Gulich, Antonia W Godehardt, Ralf R Tönjes   +5 more
openaire   +1 more source

Characterization of an ecotropic porcine endogenous retrovirus class C (PERV‐C) in a landrace pig

Xenotransplantation, 2012
Michael Rodrigues Costa, Harald Helisch, Sabrina Leugner, Jens Dorna, Ralf R. Tönjes   +4 more
openaire   +1 more source

Porcine endogenous retrovirus C (PERV C) is not transmitted following pig proislet xenotransplantation in foetal lambs

Diabetes Research and Clinical Practice, 2000
J.Dennis Wilson, David Mann, Adrian Gibbs, Peter McCullagh, Charmaine Simeonovic   +4 more
openaire   +1 more source

Porcine Endogenous Retrovirus (PERV) – Molecular Structure and Replication Strategy in the Context of Retroviral Infection Risk of Human Cells

Frontiers in Microbiology, 2018
Krzysztof Łopata, Emilia Wojdas, Roman Nowak   +2 more
exaly  

Long‐term effects of PERV‐specific RNA interference in transgenic pigs

Xenotransplantation, 2012
Björn Petersen, Joachim Denner
exaly  

Can Antiretroviral Drugs Be Used to Treat Porcine Endogenous Retrovirus (PERV) Infection after Xenotransplantation?

Viruses, 2017
Joachim Denner
exaly