Results 31 to 40 of about 148,335 (302)
Radiofluorination of a highly potent ATM inhibitor as a potential PET imaging agent
EJNMMI Research, 2022 Abstract Purpose Ataxia telangiectasia mutated (ATM) is a key mediator of the DNA damage response, and several ATM inhibitors (ATMi) are currently undergoing early phase clinical trials for the treatment of cancer. A radiolabelled ATMi to determine drug pharmacokinetics could assist patient selection in a move towards ...
Fraser C. R. +11 more
openaire +6 more sources
Designing a new molecular probe : the potential role for Tilmanocept (Lymphoseek) in the assessment of patients with painful hip and knee joint prostheses [PDF]
, 2017 There is a long history of nuclear medicine developments in orthopaedics beginning in the early 20th century. Technetium-99m (99mTc) has a short half-life of six hours, emits 140 keV gamma rays and is the most widely used isotope, imaged with the Anger ...
Adesanya, Olu. O. +1 more
core +2 more sources
Development of a New Folate-Derived Ga-68-Based PET Imaging Agent [PDF]
Molecular Imaging and Biology, 2017 The folate receptor (FR) has emerged as an interesting diagnostic and therapeutic drug target with many potential applications in oncologic and inflammatory disorders. It was therefore the aim of this study to develop a folate-derived Ga-68-based positron emission tomography (PET) imaging tracer that is straightforward to radiolabel and could be ...
Christian Brand +4 more
openaire +2 more sources
Automatic Production and Preliminary PET Imaging of a New Imaging Agent [18F]AlF-FAPT [PDF]
Frontiers in Oncology, 2022 BackgroundFibroblast activating protein (FAP) has become an important target for cancer diagnostic imaging and targeted radiotherapy. In particular, [18F]FAPI-42 has been successfully applied to positron emission tomography (PET) imaging of various tumors.
JiaWen Huang +8 more
openaire +3 more sources
Pharmaceutics, 2019 Porphyrins are known therapeutic agents for photodynamic therapy of cancer and also imaging agents for NIR fluorescence imaging, MRI, or PET. A combination of interesting features makes tetrapyrrolic macrocycles suitable for use as theranostic agents ...
Bruno F. O. Nascimento +4 more
doaj +1 more source
A PET imaging agent for evaluating PARP-1 expression in ovarian cancer [PDF]
Journal of Clinical Investigation, 2018 Poly(ADP-ribose) polymerase (PARP) inhibitors are effective in a broad population of patients with ovarian cancer; however, resistance caused by low enzyme expression of the drug target PARP-1 remains to be clinically evaluated in this context. We hypothesize that PARP-1 expression is variable in ovarian cancer and can be quantified in primary and ...
Mehran Makvandi +17 more
openaire +2 more sources
GBM radiosensitizers: dead in the water…or just the beginning? [PDF]
, 2017 The finding that most GBMs recur either near or within the primary site after radiotherapy has fueled great interest in the development of radiosensitizers to enhance local control.
Bindra, Ranjit S. +3 more
core +1 more source
Metal-Based Complexes as Pharmaceuticals for Molecular Imaging of the Liver
Pharmaceuticals, 2019 This article reviews the use of metal complexes as contrast agents (CA) and radiopharmaceuticals for the anatomical and functional imaging of the liver.
Julia Greiser +2 more
doaj +1 more source
Test–Retest Reproducibility for the Tau PET Imaging Agent Flortaucipir F 18 [PDF]
Journal of Nuclear Medicine, 2017 Alzheimer disease (AD) is characterized by β-amyloid (Aβ) plaques and tau neurofibrillary tangles. There are several PET imaging biomarkers for Aβ including 11C-PiB and 18F-florbetapir. Recently, PET tracers for tau neurofibrillary tangles have become available and have shown utility in detection and monitoring of neurofibrillary pathology over time ...
Michael D, Devous +10 more
openaire +2 more sources
Radiolabeled Iron Oxide Nanoparticles as Dual Modality Contrast Agents in SPECT/MRI and PET/MRI
Nanomaterials, 2023 During the last decades, the utilization of imaging modalities such as single photon emission computed tomography (SPECT), positron emission tomography (PET), and magnetic resonance imaging (MRI) in every day clinical practice has enabled clinicians to ...
Maria-Argyro Karageorgou +3 more
doaj +1 more source