Results 21 to 30 of about 122,171 (336)

Ciprofloxacin reduces the stimulation of prostaglandin E2 output by interleukin-1 in human tendon-derived cells [PDF]

, 2003
Fluoroquinolone antibiotics such as ciprofloxacin can induce tendon pathology and have various effects on tendon-derived cells in culture. We are investigating whether ciprofloxacin modifies signalling responses in tendon cells.
Corps, AN, Curry, VA, Dutt, D, Harrall, RL, Hazleman, BL, Riley, GP   +5 more
core   +1 more source

Multifaceted roles of PGE2 in inflammation and cancer [PDF]

Seminars in Immunopathology, 2012
Prostaglandin E(2) (PGE(2)) is a bioactive lipid that elicits a wide range of biological effects associated with inflammation and cancer. PGE(2) exerts diverse effects on cell proliferation, apoptosis, angiogenesis, inflammation, and immune surveillance.
Masako Nakanishi, Daniel W. Rosenberg
openaire   +3 more sources

Novel chalcone/aryl carboximidamide hybrids as potent anti-inflammatory via inhibition of prostaglandin E2 and inducible NO synthase activities: design, synthesis, molecular docking studies and ADMET prediction

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
Two series of chalcone/aryl carboximidamide hybrids 4a–f and 6a–f were synthesised and evaluated for their inhibitory activity against iNOS and PGE2. The most potent derivatives were further checked for their in vivo anti-inflammatory activity utilising ...
Tarek S. Ibrahim, Amr H. Moustafa, Ahmad J. Almalki, Rasha M. Allam, Abdulhamid Althagafi, Shadab Md, Mamdouh F. A. Mohamed   +6 more
doaj   +1 more source

Upregulation of prostaglandin E by inducible microsomal prostaglandin E synthase-1 in colon cancer [PDF]

Annals of Coloproctology, 2022
Purpose Prostaglandin E2 (PGE2) is known to promote carcinogenesis and cancer progression in colon cancer. Enzymes involved in the metabolism of PGE2 include cyclooxygenase (COX)-2, microsomal prostaglandin E synthase-1 (mPGES-1), and 15-prostaglandin ...
Young Hun Kim, Kyung Jong Kim
doaj   +1 more source

Combination of EP4 antagonist MF-766 and anti-PD-1 promotes anti-tumor efficacy by modulating both lymphocytes and myeloid cells

OncoImmunology, 2021
Prostaglandin E2 (PGE2), an arachidonic acid pathway metabolite produced by cyclooxygenase (COX)-1/2, has been shown to impair anti-tumor immunity through engagement with one or more E-type prostanoid receptors (EP1-4). Specific targeting of EP receptors,
Yun Wang, Long Cui, Peter Georgiev, Latika Singh, Yanyan Zheng, Ying Yu, Jeff Grein, Chunsheng Zhang, Eric S. Muise, David L. Sloman, Heidi Ferguson, Hongshi Yu, Cristina St. Pierre, Pranal J Dakle, Vincenzo Pucci, James Baker, Andrey Loboda, Doug Linn, Christopher Brynczka, Doug Wilson, Brian B Haines, Brian Long, Richard Wnek, Svetlana Sadekova, Michael Rosenzweig, Andrew Haidle, Yongxin Han, Sheila H. Ranganath   +27 more
doaj   +1 more source

Kaempferol Improves Breast Cancer-Related Depression through the COX-2/PGE2 Pathway

Frontiers in Bioscience-Landmark, 2023
Background: Breast cancer-related depression (BCRD) is strongly associated with BC and increases recurrence and mortality. This study investigated the role of kaempferol in the pathogenesis of BCRD and its underlying mechanism.
Qing Zhu, Yuanshan Han, Ying He, Yilan Fu, Hui Yang, Yun Chen, Yingrui Shi   +6 more
doaj   +1 more source

Replication of Marek's Disease Virus Is Dependent on Synthesis of De Novo Fatty Acid and Prostaglandin E2 [PDF]

, 2019
Marek’s disease virus (MDV) causes deadly lymphoma and induces an imbalance of the lipid metabolism in infected chickens. Here, we discovered that MDV activates the fatty acid synthesis (FAS) pathway in primary chicken embryo fibroblasts (CEFs).
Behboudi, Shahriar, Boodhoo, Nitish, Kamble, Nitin, Kaufer, Benedikt B.   +3 more
core   +1 more source

Gastric Antisecretory and Antiulcer Properties of PGE2, 15-Methyl PGE2, and 16,16-Dimethyl PGE2

Gastroenterology, 1976
15-Methyl PGE2 and 16,16-dimethyl PGE2 were found (1) to be 40 and 100 times, respectively, more potent than PGE2 after intravenous administration in inhibiting histamine-stimulated gastric secretion in dogs with a denervated (Heidenhain) gastric pouch, (2) to be active orally and intrajejunally, whereas PGE2 was inactive, and (3) to exert ...
André Robert, J.R. Schultz, James E. Nezamis, C. Lancaster   +3 more
openaire   +3 more sources

Dendritic cells generated from induced pluripotent stem cells and by direct reprogramming of somatic cells

European Journal of Immunology, Volume 52, Issue 12, Page 1880-1888, December 2022., 2022
Somatic cells (fibroblasts, dendritic cells, T cells) are reprogrammed into induced pluripotent stem cells (iPS cells) with specific transcription factors. iPS cells are then differentiated into iPS cell‐derived DC (ipDC) with DC inducing cytokines. Fibroblasts are directly reprogrammed into induced DC (iDC) by DC specific transcription factors (direct
Niclas Flosdorf, Martin Zenke
wiley   +1 more source

The association between repeated doses of vaginal PGE2 (Dinoprostone, Prostin®) and both maternal and neonatal outcomes among women in the north of Jordan

Clinical and Experimental Obstetrics & Gynecology, 2020
Objective: To evaluate the association between repeated doses of vaginal PGE2 and the maternal and neonatal outcomes for primigravid and multiparous women. Study design: A retrospective descriptive study was conducted at a teaching university hospital in
A.M. Sindiani, H.M. Rawashdeh, E.H. Alshdaifat, O.F. Altal, H. Yaseen, A.A. Alhowary   +5 more
doaj   +1 more source