Results 51 to 60 of about 133,795 (342)

Hambatan Prostaglandin pada Pemberian OAINS dan Non-OAINS Pasca Pemakaian Alat Ortodontik

Journal of Experimental Life Science, 2013
Alat ortodontik pada bidang kedokteran digunakan untuk merapikan gigi agar tersusun rapi dan berada pada lengkung rahang. Sehingga mengakibatkan tekanan yang akan merangsang dan menimbulkan reaksi inflamasi jaringan sekitar. Salah satu mediator inflamasi
Shanty Sintessa, H. M. Soemarko, Liliek Suprapti, Iwan Hernawan   +3 more
doaj   +1 more source

Celecoxib decreases prostaglandin E\u3csub\u3e2\u3c/sub\u3e concentrations in nipple aspirate fluid from high risk postmenopausal women and women with breast cancer [PDF]

, 2006
Background Celecoxib inhibits PGE2 production in cancerous tissue. We previously reported that PGE2 levels in nipple aspirate fluid (NAF) and plasma were not decreased in women at increased breast cancer risk who received celecoxib 200 mg twice daily ...
Flynn, John T., Hewett, John E., Quin, Wenyi, Sauter, Edward R., Schlatter, Lisa   +4 more
core   +1 more source

Postsynaptically Synthesized Prostaglandin E2 (PGE2) Modulates Hippocampal Synaptic Transmission via a Presynaptic PGE2 EP2 Receptor [PDF]

The Journal of Neuroscience, 2005
Increasing evidence suggests that cyclooxygenase-2 (COX-2) is involved in synaptic transmission and plasticity, and prostaglandin E2 (PGE2) is a key molecule in COX-2-meduated synaptic modification. However, the precise mechanisms, in particular, which subtypes of PGE2 receptors (EPs) mediate the PGE2-induced synaptic response, are not clear. Recently,
Nan, Sang, Jian, Zhang, Victor, Marcheselli, Nicolas G, Bazan, Chu, Chen   +4 more
openaire   +2 more sources

Platelet Lysate–Enriched Human Induced Pluripotent Stem Cell–Derived Chondrocyte Sheets for Bone Defect Repair via Endochondral Ossification

Advanced Healthcare Materials, EarlyView.
Human iPSC‐derived hypertrophic chondrocyte sheet promotes bone regeneration. Abstract Bone defects are a major clinical challenge, primarily owing to the limited self‐healing capacity of bones and the high risk of complications associated with conventional treatment strategies.
Yiwei Chen, Jiali Lin, Jiapeng Li, Yiwei Hu, Jiansen Su, Yu Miao, Lanlan Wang, Qian Tang, Changqing Zhang, Junhui Yin   +9 more
wiley   +1 more source

5-PGDH expression in breast cancer cells

Опухоли женской репродуктивной системы, 2014
This paper analyzes 15-PGDH gene expression in the human breast cancer (BC) cell liness and describes the molecular principles through which the expression of the enzyme 15-PGDH is controlled in the tumor cells with a varying metastatic potential.
M. A. Taipov, Z. N. Nikiforova, O. M. Pavlova, I. A. Kudryavtsev, N. Ye. Arnotskaya, V. Ye. Shevchenko   +5 more
doaj   +1 more source

Canine decidualization in vitro: extracellular matrix modification, progesterone mediated effects and selective blocking of prostaglandin E2 receptors

The Journal of Reproduction and Development, 2020
Recently, we established an in vitro model with immortalized dog uterine stromal (DUS) cells for investigations into canine-specific decidualization. Their capability to decidualize was assessed with cAMP and prostaglandin (PG) E2. Here, we show that the
Felix R. GRAUBNER, Miguel TAVARES PEREIRA, Alois BOOS, Mariusz P. KOWALEWSKI   +3 more
doaj   +1 more source

Cyclooxygenase-2 inhibitors. 1,5-diarylpyrrol-3-acetic esters with enhanced inhibitory activity toward cyclooxygenase-2 and improved cyclooxygenase-2/cyclooxygenase-1 selectivity. [PDF]

, 2007
he important role of cyclooxygenase-2 (COX-2) in the pathogenesis of inflammation and side effect limitations of current COX-2 inhibitor drugs illustrates a need for the design of new compounds based on alternative structural templates.
ANZELLOTTI P, ANZINI M., BIAVA M, BOTTA M, CAPPELLI A, FORLI S, GHELARDINI C, MAKOVEC F, MANETTI, F, PATRIGNANI P, PERGOLA, CARLO, POCE G, PORRETTA GC, ROSSI, ANTONIETTA, ROVINI M, SAUTEBIN, LIDIA, SUPINO S, VIVOLI E   +17 more
core   +1 more source

Mesenchymal Stem Cell‐Derived Apoptotic Micro‐Vesicles Repaired Sciatic Nerve Defect by Regulating Early Inflammatory Microenvironment and Promoting Angiogenesis

Advanced Healthcare Materials, EarlyView.
HUCMSC‐Apo‐mvs enhance peripheral nerve repair by modulating the inflammatory microenvironment (IME), primarily through coordinated actions on three functional cells. They recruit macrophages and promote their polarization from pro‐inflammatory M1 to anti‐inflammatory M2 phenotypes, increasing secretion of IL‐10 and VEGF.
Haolin Liu, Yiben Ouyang, Bo Wang, Xiaochun Zhang, Yanjun Guan, Ruichao He, Yuhui Cui, Junli Wang, Qianru Yao, Yixiao Tan, Xiwei Peng, Xing Xiong, Sice Wang, Dongdong Li, Haofeng Cheng, Tianqi Su, Xiaoyang Fu, Jinjuan Zhao, Mingqian Yu, Yi Wang, Jiang Peng, Yu Wang   +21 more
wiley   +1 more source

Metformin alters signaling induced crosstalk and homeostasis in the carcinogenesis paradigm “Epistemology of the origin of cancer”

4 open, 2019
The anti-hyperglycemic drug, Metformin, is effective in treating early stages of diabetes and has been associated with a 37% decrease in cancer incidence. While the precise mechanisms for the anti-cancer effects of Metformin remain to be elucidated, this
Brücher Björn L.D.M., Jamall Ijaz S.
doaj   +1 more source

TGF-β1 downregulates COX-2 expression leading to decrease of PGE2 production in human lung cancer A549 cells, which is involved in fibrotic response to TGF-β1. [PDF]

PLoS ONE, 2013
Transforming growth factor-ß1 (TGF-β1) is a multifunctional cytokine that is involved in various pathophysiological processes, including cancer progression and fibrotic disorders.
Erina Takai, Mitsutoshi Tsukimoto, Shuji Kojima   +2 more
doaj   +1 more source