Results 51 to 60 of about 122,171 (336)

Prostaglandin E2 (PGE2) exerts biphasic effects on human tendon stem cells. [PDF]

PLoS ONE, 2014
Prostaglandin E2 (PGE2) has been reported to exert different effects on tissues at low and high levels. In the present study, cell culture experiments were performed to determine the potential biphasic effects of PGE2 on human tendon stem/progenitor ...
Jianying Zhang, James H-C Wang
doaj   +1 more source

Metabotropic glutamate receptor 2/3 (mGluR2/3) activation suppresses TRPV1 sensitization in mouse, but not human sensory neurons [PDF]

, 2018
The use of human tissue to validate putative analgesic targets identified in rodents is a promising strategy for improving the historically poor translational record of preclinical pain research.
Baranger, David A.A., Gereau, Robert W, McIlvried, Lisa V, Pullen, Melanie Y, Sheahan, Tayler D, Valtcheva, Manouela V   +5 more
core   +2 more sources

Role of TGF-β1/SMAD signaling cascade in the regulation of cyclooxygenase-2 expression in human breast cancer cells

Опухоли женской репродуктивной системы, 2014
The expression of the SMAD2, SMAD4, SMAD7, and СOX-2 genes and the levels of Smad4, phosphorylated Smad2, and Smad7 proteins were analyzed in the human breast cancer (BC) cell lines MCF-7, BT-474, and ZR-75-1.
M. A. Taipov, Z. N. Nikiforova, O. M. Pavlova, I. A. Kudryavtsev, N. Ye. Arnotskaya, V. Ye. Shevchenko   +5 more
doaj   +1 more source

Staphylococcus aureus enterotoxin B regulates prostaglandin E-2 synthesis, growth, and migration in nasal tissue fibroblasts [PDF]

, 2008
Background. Superantigens and eicosanoids are important amplifiers and regulators of inflammation in airway diseases. We therefore studied the possible influence of Staphylococcus aureus enterotoxin B ( SEB) on the cyclooxygenase ( COX) pathway and basic
Bachert, Claus, Claeys, Cindy, Perez Novo, Claudina, Van Cauwenberge, Paul, Waeytens, Anouk   +4 more
core   +2 more sources

Extensive Molecular Dynamics Simulations Disclosed the Stability of mPGES‐1 Enzyme and the Structural Role of Glutathione (GSH) Cofactor

Molecular Informatics, Volume 41, Issue 12, December 2022., 2022
Abstract A deep in silico investigation of various microsomal prostaglandin E2 synthase‐1 (mPGES‐1) protein systems is here reported using molecular dynamics (MD) simulations. Firstly, eight different proteins models (Models A−H) were built, starting from the active enzyme trimer system (Model A), namely that bound to three glutathione (GSH) cofactor ...
Simone Di Micco, Gianluigi Lauro, Giuseppe Bifulco   +2 more
wiley   +1 more source

The sustained PGE2 release matrix improves neovascularization and skeletal muscle regeneration in a hindlimb ischemia model

Journal of Nanobiotechnology, 2022
Background The promising therapeutic strategy for the treatment of peripheral artery disease (PAD) is to restore blood supply and promote regeneration of skeletal muscle regeneration.
Haoyan Huang, Shang Chen, Hui Cheng, Jiasong Cao, Wei Du, Jun Zhang, Yuqiao Chang, Xiaohong Shen, Zhikun Guo, Zhibo Han, Guoqiang Hua, Zhong-Chao Han, Nadia Benkirane-Jessel, Ying Chang, Zongjin Li   +14 more
doaj   +1 more source

Proteomic Analysis of Tendon Extracellular Matrix Reveals Disease Stage- specific Fragmentation and Differential Cleavage of COMP ( Cartilage Oligomeric Matrix Protein) [PDF]

, 2014
During inflammatory processes the extracellular matrix (ECM) is extensively remodeled, and many of the constituent components are released as proteolytically cleaved fragments.
Almekinders, Arner, Arur, Avella, Birch, Crevier-Denoix, Dakin, Dakin, Dakin, Dickinson, Dowling, Dudhia, Ganu, Halász, Heinemeier, Jozsa, Järvinen, Ker, Knudsen, Kozaci, Kujala, Langberg, Langberg, Levy, Ley, Lui, Millar, Millar, Miyatake, Mort, Murphy, Neidhart, Oldberg, Perez-Castro, Rappsilber, Rappsilber, Riley, Riley, Saxne, Schulze-Tanzil, Shohani, Smith, Smith, Smith, Smith, Smith, Smith, Strocchi, Sztrolovics, Thorpe, Tsuzaki, Wilson   +51 more
core   +1 more source

Brazilian medicinal plants with corroborated anti-inflammatory activities: a review

Pharmaceutical Biology, 2018
Context: Inflammatory disorders are common in modern life, and medicinal plants provide an interesting source for new compounds bearing anti-inflammatory properties.
Victor Pena Ribeiro, Caroline Arruda, Mohamed Abd El-Salam, Jairo Kenupp Bastos   +3 more
doaj   +1 more source

Tissue lipidomic profiling supports a mechanistic role of the prostaglandin E2 pathway for albuminuria development in glomerular hyperfiltration

Frontiers in Network Physiology, 2023
Background: Glomerular hyperfiltration (GH) is an important mechanism in the development of albuminuria in hypertension. The Munich Wistar Frömter (MWF) rat is a non-diabetic model of chronic kidney disease (CKD) with GH due to inherited low nephron ...
Debora Kaiser-Graf, Angela Schulz, Eva Mangelsen, Michael Rothe, Juliane Bolbrinker, Reinhold Kreutz   +5 more
doaj   +1 more source

The immunological interface: dendritic cells as key regulators in metabolic dysfunction‐associated steatotic liver disease

FEBS Letters, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi, WanTing Kong, Camille Blériot, Joel T. Haas   +3 more
wiley   +1 more source