Results 71 to 80 of about 5,258 (146)
Cell Proliferation, Volume 59, Issue 8, August 2026.Elucidating the contribution of gut‐organ axes will provide new insights for developing combined therapeutic strategies against sepsis‐associated multiple organ dysfunction. ABSTRACT Sepsis, a life‐threatening clinical syndrome precipitated by a maladaptive host response to infection, is associated with substantial morbidity and high mortality rates ...
Yichen Bao +7 more
wiley +1 more source
Comparative study on the virulence of mycobacteriophages
Journal of VirologyThe global tuberculosis (TB) epidemic affected 10 million people and caused 1.3 million deaths in 2022 alone. Multidrug-resistant TB is successfully treated in less than 60% of cases by long, expensive, and aggressive treatments.
Ilaria Rubino +10 more
doaj +1 more source
Virus Research, 2019 The control and treatment of multidrug resistant pathogens infections has become a grand challenge for clinicians worldwide. Virulent phage has long been considered as an effective bactericidal agent, which may be a potentially alternative to antibiotics.
Yuyu, Yuan +5 more
openaire +2 more sources
AntibioticsThe specificity of phages and their ability to evolve and overcome bacterial resistance make them potentially useful as adjuncts in the treatment of antibiotic-resistant bacterial infections.
Tea Glonti +7 more
doaj +1 more source
Bioinformatics AdvancesAbstract Motivation Phage therapy is emerging as a promising alternative to antibiotics in biomedical research, highlighting the growing need for computational tools to rationally design effective phage cocktails.
Felipe Molina +2 more
openaire +2 more sources
Lytic Activity of Various Phage Cocktails on Multidrug-Resistant Bacteria
Clinical and Investigative Medicine, 2016 Purpose A bacteriophage is a virus that infects and replicates within a bacterium following the injection of phage genome into the bacterial cytoplasm. They are seen as a possible therapy for multi-drug-resistant strains of many bacteria. The aim of this study is to evaluate the lytic activity of the Pyo, Intesti and Fersisi bacteriophage cocktails on ...
I, Ozkan +5 more
openaire +3 more sources
A New Approach for Phage Cocktail Design in the Example of Anti-Mastitis Solution
PathogensThe studies on phage therapy have shown an overall protective effect of phages in bacterial infections, thus providing an optimistic outlook on the future benefits of phage-based technologies for treating bacterial diseases.
Daria Królikowska +9 more
doaj +1 more source
Frontiers in MicrobiologyLytic bacteriophages (phages) are promising clinically viable therapeutic options against carbapenem-resistant Klebsiella pneumoniae (CRKP). In China, the predominant strains are those assigned to sequence type 11 and capsular type 64 (ST11-KL64).
Juan Li +10 more
doaj +1 more source
FORMULATING PHAGE COCKTAILS AS ADJUVANT THERAPY IN CARBAPENEM-RESISTANT PSEUDOMONAS AERUGINOSA
Open Respiratory ArchivesIntroduction: Phage-antibiotic synergy (PAS) results in bacterial killing beyond the efficacy of either agent alone. Although the main candidates for therapeutic PAS are lytic phages, temperate phages have been re-evaluated in light of PAS.
Viviane de Cássia Oliveira +6 more
doaj +1 more source
Phage Therapy at the Crossroads Between Clinical Promise and Regulatory Challenge
PharmaceuticalsBacteriophage (phage) therapy, including monophage preparations, phage cocktails, engineered phages, and phage-derived enzymes, has re-emerged as a potential option for difficult-to-treat and biofilm-associated infections in the context of rising ...
Anna Gallina +5 more
doaj +1 more source