Results 71 to 80 of about 64,822 (118)

Post‐Microbial Therapeutics for the Next Generation of Medicine

MicrobiologyOpen, Volume 15, Issue 5, October 2026.
Post‐microbial therapeutics: from microbial perturbation to host benefit. Post‐microbial therapeutics provide a function‐centered framework that links targeted microbial perturbation to changes in microbial modules and metabolites, followed by measurable host responses. Phages and phage‐derived interventions can selectively modify bacterial populations
Mohammad Nazrul Islam Bhuiyan, Maliha Momtaj   +1 more
wiley   +1 more source

Comparative assessment of strategic application of mono-and-cocktail phage therapy in combatting dual-species biofilm architecture: A new hope for medical device sanitization

The Microbe
Invasive and implant-associated biofilms represent a hypercritical challenge in clinical settings where polymicrobial pathogens, including both Gram-positive and Gram-negative bacteria, colonise on medical devices, such as catheters, endotracheal tubes ...
Bershiyal Sugumar, Ramya Juliet, Rithviha Thirumurugan, Oishi Mitra, Nissy A. Bovas, Yogeswaran Jagadeesan, Prasanth Manohar, Ramesh Nachimuthu   +7 more
doaj   +1 more source

Efficiency of phage cocktails in the inactivation of Vibrio in aquaculture

Aquaculture is one of the fastest growing sectors in the world, having a very important role in the economy. However, the losses associated with bacterial infections such as vibriosis, lead to huge economic costs.
Almeida, A., Cunha, A., Mateus, L., Pereira, C., Silva, Y. J., Costa, L.   +5 more
core   +1 more source

Persistence of bacteriophage T4 in a starved Escherichia coli culture: evidence for the presence of phage subpopulations. [PDF]

, 2011
Bacteriophage T4 is able to adjust its development to the growth parameters of the host cell. Here, we present evidence for the production of two different subpopulations of phage particles, which differ in their ability to infect starved Escherichia ...
Wiczk, Aleksandra, Łoś, Marcin, Konopa, Grażyna, Węgrzyn, Grzegorz, Golec, Piotr, Łoś, Joanna M   +5 more
core   +1 more source

Phage-encoded endolysins

, 2021
© 2021 by the authors. Licensee MDPI, Basel, Switzerland. Due to the global emergence of antibiotic resistance, there has been an increase in research surrounding endolysins as an alternative therapeutic. Endolysins are phage-encoded enzymes, utilized by
S Ragab (10493912), M Easwaran (10493906), E Torrents (7764899), Stephanie Lynch (9491282), OI Daramola (10493909), TJ Oduselu (10493915), A El-Shibiny (10493930), FM Khan (10493918), F Abdelrahman (10493903), A Ayobami (10493921), S Sanmukh (10493927), F Adnan (10493924)   +11 more
core   +1 more source

Building coiled coils with polar cores

Protein Science, Volume 35, Issue 10, October 2026.
Abstract Coiled coils are formed by α‐helices winding around each other into superhelical bundles. They are characterized by a specific geometry of interaction, called knobs‐into‐holes, in which residues in the core of the structure mesh regularly along a seam that runs the length of the helices.
Marcus D. Hartmann, Birte Hernandez Alvarez, Mikel Martinez‐Goikoetxea, Andrei N. Lupas   +3 more
wiley   +1 more source

Comparative study on the virulence of mycobacteriophages

Journal of Virology
The global tuberculosis (TB) epidemic affected 10 million people and caused 1.3 million deaths in 2022 alone. Multidrug-resistant TB is successfully treated in less than 60% of cases by long, expensive, and aggressive treatments.
Ilaria Rubino, Carlos A. Guerrero-Bustamante, Melissa Harrison, Sheila Co, Isobel Tetreau, Mani Ordoubadi, Sasha E. Larsen, Rhea N. Coler, Reinhard Vehring, Graham F. Hatfull, Dominic Sauvageau   +10 more
doaj   +1 more source

Single Treatment of Mature 3D Single-, Dual- and Poly-Species Biofilms Using a Combination Therapy of Phage or Phage-Hetero-Cocktails and Ciprofloxacin

Antibiotics
Background/Objectives: Biofilms are a form of defense that enables bacteria to withstand antibiotic pressure and demonstrate antibiotic resistance. It is crucial to develop anti-biofilm strategies in order to combat chronic and persistent multidrug ...
Tea Glonti, Merve Kübra Aktan, Christel Cochez, Naiera Zayed, Annabel Braem, Wim Teughels, Jean-Paul Pirnay   +6 more
doaj   +1 more source

Phage-inspired strategies to combat antibacterial resistance

, 2023
Antimicrobial resistance (AMR) in clinically priority pathogensis now a major threat to public health worldwide. Phages are bacterial parasites that efficiently infect or kill specific strains and represent the most abundant biological entities on earth,
Zhiqiang Wang (48987), Junxuan Zhang (14662600), Lei Jiang (73366), Li Jiang (120930), Jingyi Wei (5806190), Mianzhi Wang (5857439), Yongxue Sun (4851643), Zhenling Zeng (3404546)   +7 more
core   +1 more source

Use of the Naturally Occurring Bacteriophage Grouping Model for the Design of Potent Therapeutic Cocktails

Antibiotics
The specificity of phages and their ability to evolve and overcome bacterial resistance make them potentially useful as adjuncts in the treatment of antibiotic-resistant bacterial infections.
Tea Glonti, Michael Goossens, Christel Cochez, Sabrina Green, Sayali Gorivale, Jeroen Wagemans, Rob Lavigne, Jean-Paul Pirnay   +7 more
doaj   +1 more source