Results 71 to 80 of about 149,596 (212)
Advanced Science, EarlyView.Osteosarcoma is the most common primary bone tumor with limited treatment options and a terrible prognosis. This review provides a comprehensive summary of the recent development of osteoimmunomodulatory implants for post‐operative osteosarcoma treatment, of which the potential utility in evoking durable anti‐osteosarcoma immunity and accelerating bone
Yilong Dong +6 more
wiley +1 more source
Development of a broad-host-range phage cocktail for biocontrol [PDF]
Bioengineered Bugs, 2011 The aims of this study were to investigate the incidence of different resistance mechanisms to phage K in a bank of Irish Staph aureus hospital strains; and to develop a broad host-range phage cocktail with enhanced lytic activity against those strains which were previously phage resistant.
David, Kelly +4 more
openaire +2 more sources
<i>SocialViruses</i>: integrating quantitative phage-bacteria and phage-phage interaction networks for rational cocktail design. [PDF]
Bioinform AdvAbstract Motivation Phage therapy is emerging as a promising alternative to antibiotics in biomedical research, highlighting the growing need for computational tools to rationally design effective phage cocktails.
Molina F +2 more
europepmc +3 more sources
Bacteriophages and bacterial plant diseases [PDF]
, 2017 Losses in crop yields due to disease need to be reduced in order to meet increasing global food demands associated with growth in the human population. There is a well-recognized need to develop new environmentally friendly control strategies to combat ...
Buttimer, Colin +5 more
core +2 more sources
Unraveling the Molecular Mechanisms Underlying Spontaneous Multipolar Mitosis Through CIN‐seq
Advanced Science, EarlyView.Multipolar mitosis, a hallmark of chromosomal instability (CIN), drives tumor heterogeneity but is challenging to study in live cells. Using CIN‐seq, a single‐cell multiomics method, we profiled rare CIN events and identified mechanisms associated with viable multipolar mitosis, including PTEN attenuation, Rho GTPase‐driven cytokinesis failure, and ...
Pin‐Rui Su +10 more
wiley +1 more source
Determinants of Phage Host Range in Staphylococcus Species. [PDF]
, 2019 Bacteria in the genus Staphylococcus are important targets for phage therapy due to their prevalence as pathogens and increasing antibiotic resistance.
Lindsay, JA, Moller, AG, Read, TD
core +1 more source
Advanced Science, EarlyView.This study presents the de novo design and directed evolution of a mirror‐image D‐protein inhibitor targeting human interleukin‐4 (IL‐4). The engineered molecule exhibits nanomolar binding affinity for IL‐4 and effectively inhibits IL‐4–mediated signaling.
Liqing Xu +7 more
wiley +1 more source
Optimizing bacteriophage treatment of resistant Pseudomonas
mSpherePhage therapy is increasing in relevance as an alternative treatment to combat antibiotic resistant bacteria. Phage cocktails are the state-of-the-art method of administering phages in clinical settings, preferred over monophage treatment because of ...
Laura Ulrich +3 more
doaj +1 more source
Phage cocktail strategies for the suppression of a pathogen in a cross‐feeding coculture
Microbial Biotechnology, 2020 Summary Cocktail combinations of bacteria‐infecting viruses (bacteriophages) can suppress pathogenic bacterial growth. However, predicting how phage cocktails influence microbial communities with complex ecological interactions, specifically cross ...
Lisa Fazzino +3 more
doaj +1 more source
Genetically Engineered Phages: a Review of Advances over the Last Decade [PDF]
, 2016 Summary: Soon after their discovery in the early 20th century, bacteriophages were recognized to have great potential as antimicrobial agents, a potential that has yet to be fully realized.
Alberts B +17 more
core +1 more source