Isolation and characterization of φkm18p, a novel lytic phage with therapeutic potential against extensively drug resistant Acinetobacter baumannii. [PDF]
PLoS ONE, 2012 AIMS: To isolate phages against extensively drug resistant Acinetobacter baumannii (XDRAB) and characterize the highest lytic capability phage as a model to evaluate the potential on phage therapy.
Gwan-Han Shen +7 more
doaj +1 more source
Lytic Activity of Various Phage Cocktails on Multidrug-Resistant Bacteria.
Clinical and Investigative Medicine, 2016 Purpose A bacteriophage is a virus that infects and replicates within a bacterium following the injection of phage genome into the bacterial cytoplasm. They are seen as a possible therapy for multi-drug-resistant strains of many bacteria. The aim of this study is to evaluate the lytic activity of the Pyo, Intesti and Fersisi bacteriophage cocktails on ...
I. Ozkan +5 more
semanticscholar +4 more sources
The Promising Viral Threat to Bacterial Resistance: The Uncertain Patentability of Phage Therapeutics and the Necessity of Alternative Incentives [PDF]
, 2019 Bacteriophages, or “phages,” are a category of highly adept and adaptable viruses that can infect and kill bacteria. With concerns over the burgeoning antibiotic-resistance crisis looming in recent years, scientists and policymakers have expressed a ...
Todd, Kelly
core +2 more sources
The preclinical and clinical progress of bacteriophages and their lytic enzymes : the parts are easier than the whole [PDF]
, 2019 The therapeutic potential of phages has been considered since their first identification more than a century ago. The evident concept of using a natural predator to treat bacterial infections has, however, since then been challenged considerably ...
Abdelkader, Karim Abdelkader Soufi +4 more
core +1 more source
Investigating bacteriophages targeting the opportunistic pathogen Acinetobacter baumannii [PDF]
, 2020 The multi-drug resistance of the opportunistic pathogen Acinetobacter baumannii is of growing concern, with many clinical isolates proving to be resistant to last resort as well as front line antibiotic treatments.
Christie, Gabrielle S. +10 more
core +1 more source
Revisiting phage therapy: new applications for old resources [PDF]
, 2015 The success of phage therapy is dependent on the development of strategies able to overcome the limitations of bacteriophages as therapeutic agents, the creation of an adequate regulatory framework, the implementation of safety protocols, and the ...
Azeredo, Joana +3 more
core +1 more source
mSystemsBacteriophages are emerging as promising alternatives to antibiotics for multidrug-resistant (MDR) infections. However, their unique pharmacokinetic and pharmacodynamic (PKPD) properties arising from host-dependent amplification present challenges for ...
Jun Seok Cha +9 more
doaj +1 more source
Antibody Production in Response to Staphylococcal MS-1 Phage Cocktail in Patients Undergoing Phage Therapy [PDF]
Frontiers in Microbiology, 2016 In this study, we investigated the humoral immune response (through the release of IgG, IgA, and IgM antiphage antibodies) to a staphylococcal phage cocktail in patients undergoing experimental phage therapy at the Phage Therapy Unit, Medical Center of the Ludwik Hirszfeld Institute of Immunology and Experimental Therapy in Wrocław, Poland.
Maciej Żaczek +15 more
openaire +3 more sources
A blueprint for broadly effective bacteriophage-antibiotic cocktails against bacterial infections
Nature CommunicationsBacteriophage (phage) therapy is a promising therapeutic modality for multidrug-resistant bacterial infections, but its application is mainly limited to personalized therapy due to the narrow host range of individual phages.
Minyoung Kevin Kim +8 more
doaj +1 more source
International Journal of Antimicrobial AgentsPhage-based decontamination has rarely been explored in real-world settings, particularly in the environments of patients undergoing extracorporeal membrane oxygenation (ECMO).
C. Tseng +11 more
semanticscholar +1 more source