Results 201 to 210 of about 63,473 (252)
Some of the next articles are maybe not open access.
2017
Metasecretome is a collection of cell-surface and secreted proteins that mediate interactions between microbial communities and their environment. These include adhesins, enzymes, surface structures such as pili or flagella, vaccine targets or proteins responsible for immune evasion.
Milica, Ciric +3 more
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Metasecretome is a collection of cell-surface and secreted proteins that mediate interactions between microbial communities and their environment. These include adhesins, enzymes, surface structures such as pili or flagella, vaccine targets or proteins responsible for immune evasion.
Milica, Ciric +3 more
openaire +2 more sources
2000
The development of monoclonal antibody (mAb) technology (1) has had a significant impact on many fields of research, in particular immunology. However, the method has limitations. The use of recombinant DNA technology and demonstration by Smith 1985 (2) that peptides can be expressed on the surface of filamentous bacteriophages have permitted the ...
M, Johns, D B, Palmer
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The development of monoclonal antibody (mAb) technology (1) has had a significant impact on many fields of research, in particular immunology. However, the method has limitations. The use of recombinant DNA technology and demonstration by Smith 1985 (2) that peptides can be expressed on the surface of filamentous bacteriophages have permitted the ...
M, Johns, D B, Palmer
openaire +4 more sources
Immunotechnology, 1995
Phage display is a powerful method for the selection and evolution of proteins and peptides. Applications include the generation of potent and novel antibodies, the in vitro improvement of protein affinity and function, epitope discovery, the development of leads for vaccine research and the identification of interacting proteins using cDNA libraries.
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Phage display is a powerful method for the selection and evolution of proteins and peptides. Applications include the generation of potent and novel antibodies, the in vitro improvement of protein affinity and function, epitope discovery, the development of leads for vaccine research and the identification of interacting proteins using cDNA libraries.
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2017
ORFeome phage display allows the efficient functional screening of entire proteomes or even metaproteomes to identify immunogenic proteins. For this purpose, randomly fragmented, whole genomes or metagenomes are cloned into a phage-display vector allowing positive selection for open reading frames (ORF) to improve the library quality.
Jonas, Zantow +3 more
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ORFeome phage display allows the efficient functional screening of entire proteomes or even metaproteomes to identify immunogenic proteins. For this purpose, randomly fragmented, whole genomes or metagenomes are cloned into a phage-display vector allowing positive selection for open reading frames (ORF) to improve the library quality.
Jonas, Zantow +3 more
openaire +2 more sources
Phage Display of Antibody Fragments
Current Protein and Peptide Science, 2000In recent years, phage display of peptides and proteins has become a very popular method in oncology, immunology, protein engineering and ligand-receptor studies among others. Antibody fragments, as Fabs or single chain Fv, have been among the first proteins to be displayed on the surface of a filamentous bacteriophage with a procedure initially ...
PINI, ALESSANDRO, BRACCI, LUISA
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Phage Displayed Peptide Libraries
Combinatorial Chemistry & High Throughput Screening, 1999Peptide libraries may be constructed by grafting, in vitro, random DNA sequences into a carrier gene and then introducing the degenerate hybrid coding sequence into an expression organism. This review will focus on phage display, which was the first expression organism for peptide library expression to be described and which still maintains ...
Cesareni G, Castagnoli L, Cestra G
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2016
Chemokines are small chemoattractant proteins involved in the recruitment of leukocytes to the site of inflammation. Due to their prominent role in the inflammatory process, chemokine inhibitors have been developed by parasites to remain undetected not only by the host immune system but also by various laboratories to develop anti-inflammatory ...
Pauline, Bonvin +3 more
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Chemokines are small chemoattractant proteins involved in the recruitment of leukocytes to the site of inflammation. Due to their prominent role in the inflammatory process, chemokine inhibitors have been developed by parasites to remain undetected not only by the host immune system but also by various laboratories to develop anti-inflammatory ...
Pauline, Bonvin +3 more
openaire +2 more sources
2008
Molecular imaging is at the forefront in the advancement of in-vivo diagnosis and monitoring of cancer. New peptide-based molecular probes to facilitate cancer detection are rapidly evolving. Peptide-based molecular probes that target apoptosis, angiogenesis, cell signaling and cell adhesion events are in place. Bacteriophage (phage) display technology,
Jessica, Newton, Susan L, Deutscher
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Molecular imaging is at the forefront in the advancement of in-vivo diagnosis and monitoring of cancer. New peptide-based molecular probes to facilitate cancer detection are rapidly evolving. Peptide-based molecular probes that target apoptosis, angiogenesis, cell signaling and cell adhesion events are in place. Bacteriophage (phage) display technology,
Jessica, Newton, Susan L, Deutscher
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Phage display and pharmacogenomics
Pharmacogenomics, 2000Surface display of genetic diversity is a technology that can produce specific binding agents for almost any target molecule, and is especially well suited for making agents that bind specific proteins. Until now, pharmacogenomic studies have followed the response of cells to drugs and other agents by tracking the mRNAs that encode the proteins of ...
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Immunology & Cell Biology, 2002
Phage display provides a powerful technique for rapidly selecting a particular binding clone from millions of other irrelevant clones. One of the first applications of this technology was in the display and isolation of monoclonal antibodies. More recently, phage display technology has been increasingly used in other areas of research, such as in the ...
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Phage display provides a powerful technique for rapidly selecting a particular binding clone from millions of other irrelevant clones. One of the first applications of this technology was in the display and isolation of monoclonal antibodies. More recently, phage display technology has been increasingly used in other areas of research, such as in the ...
openaire +3 more sources