Results 61 to 70 of about 167 (163)

Synthetic Biology‐Based Engineering Living Therapeutics for Antimicrobial Application

Exploration, EarlyView.
This perspective highlights synthetic biology‐driven antibacterial strategies, focusing on three innovative approaches: engineered bacteriophages for precision bacterial targeting, reprogrammed microbes that detect quorum‐sensing signals or metabolites to release antimicrobials, and engineering mammalian cells that recognize pathogen‐associated ...
Shun Huang, Shuihao Zhao, Haijie Zhao, Mingzhang Wen, Zhong Guo   +4 more
wiley   +1 more source

Recent Advancements in Ambient‐Air Fabrication of Perovskite Solar Cells

Exploration, EarlyView.
This review explores the fabrication of perovskite solar cells (PSCs) in ambient air, highlighting strategies to enhance their stability and performance. It discusses challenges such as degradation under environmental conditions and outlines methods for large‐scale manufacturing, offering insights into the commercialization and future development of ...
Yihuai Huang, Wenguang Zhang, Yuchen Xiong, Zijun Yi, Changkai Huang, Qinghui Jiang, Abdul Basit, Guibin Shen, Yubo Luo, Xin Li, Junyou Yang   +10 more
wiley   +1 more source

Overcoming Toxicity Barriers for Boosting Nisin Synthesis in Lactococcus lactis Strain via Adaptive Laboratory Evolution

Food Chemistry International, EarlyView.
After adaptive laboratory evolution against nisin, improved nisin production and tolerance were found in the evolved strains. To reveal the advantages of the evolved strains, a systematic comparison was made between the starting strains and the domesticated strains in terms of their microscopic morphology, metabolomics, transcriptomics, and whole ...
Xinyue Liu, Yuwei Sun, Jiang Zhu, Fang Wang, Zhijia Liu, Yanfei Wang, Shengbao Cai, Junjie Yi   +7 more
wiley   +1 more source

Pathogenic Escherichia coli Virulome in Top Soil Improvers and Irrigation Waters Devoted to Leafy Vegetable Production: Hazard Assessment From a Case Study in Italy

Food Safety and Health, EarlyView.
Escherichia coli pathotype virulotyping to assess if combined top soil improver and water inputs would potentially lead to hybrid strains with shuffled virulence features in ready‐to‐eat vegetables. This is to support the transition toward safe and sustainable food production systems.
Giorgia Barbieri, Federica Gigliucci, Sofia Palma, Fabio Minelli, Paola Chiani, Manuela Marra, Maria Carollo, Arnold Knijn, Gianfranco Brambilla, Stefano Morabito   +9 more
wiley   +1 more source

Deregulated enhancer‐promoter communication in cancer through altered nuclear architecture

International Journal of Cancer, EarlyView.
Abstract Enhancers are critical regulators of gene expression. Structural variations in cancer genomes can lead to enhancer hijacking, where oncogenes are activated by mistargeted enhancer activity. Novel enhancer‐promoter interactions may also arise through chromosomal rearrangements that create extrachromosomal DNA elements.
Isabelle Seufert, Claire Vargas, Sina Jasmin Wille, Karsten Rippe   +3 more
wiley   +1 more source

Construction of Reporter Phage T4::Nluc and Its Application in the Detection of Escherichia coli in Urinary Tract Infections

iLABMED, EarlyView.
A reporter phage T4::Nluc was constructed using the CRISPR/Cas9 system combined with homologous recombination and was applied for the detection of clinical Escherichia coli in urinary tract infections (UTIs). T4::Nluc exhibited superior sensitivity and specificity, and had a short detection time, making it a powerful tool for diagnosing UTIs.
Zhiyun Hao, Minwei Li, Qiang Zhao, Liye Wang, Ting Liu, Chi Wang, Chengbin Wang   +6 more
wiley   +1 more source

Functional and evolutionary characterization of potential auxiliary metabolic genes of the global RNA virome

iMetaOmics, EarlyView.
We generated the first comprehensive view of RNA viral auxiliary metabolic genes (AMGs), expanding the known functional type of AMGs by 75%. RNA viruses encode a remarkably high diversity of AMGs, spanning 25 distinct functional categories. Most of these genes are linked to environmental regulation and genetic information processing, with fewer ...
Yang Zhao, Zhihao Zhang, Meiling Feng, Rong Wen, Pengfei Liu   +4 more
wiley   +1 more source

Scaling‐up RADseq methods for large datasets of non‐invasive samples: Lessons for library construction and data preprocessing

Molecular Ecology Resources, EarlyView., 2023
Abstract Genetic non‐invasive sampling (gNIS) is a critical tool for population genetics studies, supporting conservation efforts while imposing minimal impacts on wildlife. However, gNIS often presents variable levels of DNA degradation and non‐endogenous contamination, which can incur considerable processing costs. Furthermore, the use of restriction‐
Larissa S. Arantes, Jilda A. Caccavo, James K. Sullivan, Sarah Sparmann, Susan Mbedi, Oliver P. Höner, Camila J. Mazzoni   +6 more
wiley   +1 more source

Skin microbiome engineering: Challenges and opportunities in skin diseases treatment

iMetaOmics, EarlyView.
The skin microbiome plays a crucial role in skin health, influencing barrier integrity, immune responses, and disease susceptibility. Various interventions can reshape the microbiome, broadly categorized into targeted and untargeted approaches. Targeted strategies, such as phage therapy, engineered bacteria, and phage lysins, selectively modulate ...
Yiang Lyu, Juntao Shen, You Che, Lei Dai
wiley   +1 more source

Spaceflight redefines ageing‐associated microbiota

iMeta, EarlyView.
Spaceflight reshapes microbiota and immune function, mitigating some ageing effects while accelerating immune aging, revealing crucial insights for astronaut health and longevity in space missions.
Yuan Sun, Sai Liu, Long Chen, Zheng Zhou, Mengyu Ma, Jinran Li, Yi Lu, Yiting Shi, Tingting Yao, Ruizhi Feng, Qiulun Lu, Fatimah Qassadi, Philip M. Williams, Tanya M. Monaghan, Guangji Wang, Zheying Zhu, Xinuo Li   +16 more
wiley   +1 more source