Results 91 to 100 of about 33,269 (261)
The extraordinary phagosome [PDF]
Nature, 2002 The finding that a cellular compartment called the endoplasmic reticulum can merge with the cell's outer membrane is surprising. It would not have been predicted from our knowledge of cell organization.
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Advanced Science, EarlyView.This study introduces a biomimetic “nanofusion” platform that integrates the biostability of threose nucleic acids (TNA) with homotypic cell‐membrane cloaking to combat drug‐resistant TNBC. By leveraging a non‐canonical membrane‐fusion pathway for direct cytosolic delivery, the platform bypasses endosomal sequestration. To achieve potent AKT2 silencing
Wei Zheng +7 more
wiley +1 more source
A Drosophila Model to Image Phagosome Maturation [PDF]
, 2013 Phagocytosis involves the internalization of extracellular material by invagination of the plasma membrane to form intracellular vesicles called phagosomes, which have functions that include pathogen degradation.
Alexandra Sorvina +8 more
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Image_2_A Bumpy Ride of Mycobacterial Phagosome Maturation: Roleplay of Coronin1 Through Cofilin1 and cAMP.tif [PDF]
, 2021 Phagosome-lysosome fusion in innate immune cells like macrophages and neutrophils marshal an essential role in eliminating intracellular microorganisms.
Ajay Vir Singh (11470543) +5 more
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Vomocytosis: Too Much Booze, Base, or Calcium?
mBio, 2019 Macrophages are well known for their phagocytic activity and their role in innate immune responses. Macrophages eat non-self particles, via a variety of mechanisms, and typically break down internalized cargo into small macromolecules.
Melissa Cruz-Acuña +2 more
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Maintaining phagosome integrity during fungal infection: do or die?
Microbial Cell, 2020 Professional phagocytes represent a critical node in innate immunity and tissue homeostasis through their specialized ability to eat, drink, and digest material from the extracellular milieu.
Mabel Yang +2 more
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Advanced Science, EarlyView.This study identifies RNA‐binding protein RBM25 as a broad‐spectrum antiviral factor acting independently of type I interferon. It blocks viral entry by suppressing GTPase Rab22a via the RC3H1‐mediated destabilization of Rab22a mRNA. Viral downregulation of RBM25 enhances GTPase Rab22a expression and viral entry, revealing an unreported post ...
Yingying Ding +13 more
wiley +1 more source
Characterizing Rab18: A Novel Regulator of Phagosome Maturation [PDF]
, 2017 Phagosome maturation is a complex, evolutionarily conserved process that allows white blood cells of the immune system to destroy microbes engulfed by phagocytosis. Despite the tremendous medical relevance of phagosome maturation, the functions of only a
Mobina Roshandell
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Quantitative analysis of phagosome formation and maturation using an Escherichia coli probe expressing a tandem fluorescent protein [PDF]
Phagosome formation and maturation are essential innate immune mechanisms to engulf and digest foreign particles. To analyze these processes quantitatively, we established a specific Escherichia coli probe expressing a tandem fluorescent protein ...
堀, 直裕 +23 more
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Mycobacterium tuberculosis phagosome [PDF]
Molecular Microbiology, 1999 The arrest of Mycobacterium tuberculosis phagosome maturation in infected macrophages is a phenomenon of dual significance both for the pathogenesis of tuberculosis and as a model system to study interference of microbes with membrane trafficking and organelle biogenesis in host cells.
Deretic, Vojo, Fratti, R. A.
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