Results 101 to 110 of about 32,198 (216)
, 2003 Pathogenic mycobacteria such as Mycobacterium tuberculosis and Mycobacterium avium facilitate disease by surviving intracellularly within a potentially hostile environment: the macrophage phagosome. They inhibit phagosome maturation processes, including
Moniz-Pereira, J +11 more
core +1 more source
The FASEB Journal, Volume 40, Issue 11, 15 June 2026.Legionella pneumophila infection leads to the release of pathogen‐associated molecular patterns, which recruits the adaptor protein MYD88, initiating both activating (e.g., NF‐κB) and inhibitory (e.g., PI3K/AKT) signaling pathways that regulate IL‐12 gene expression.
Kara Vasilew +12 more
wiley +1 more source
Characterization of the Role of WASH on Phagosome Maturation
, 2014 During phagosome maturation, phagosomes fuse with endo/lysosomal compartments.
Szeto, Gi Kwun Vivian
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In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, Volume 600, Issue 11, Page 1589-1604, June 2026.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Nanodiamond Quantum Sensors for Probing Free Radical Biology
Advanced Functional Materials, Volume 36, Issue 45, 5 June 2026.Free radicals play key roles in cellular signaling and disease but remain difficult to measure in living systems. Nanodiamonds (NDs) with nitrogen‐vacancy (NV) centers enable quantum sensing of local magnetic noise via T₁ relaxometry, providing nondestructive radical detection in living cells.
Qi Lu, Yingke Wu, Tanja Weil
wiley +1 more source
Advanced Science, Volume 13, Issue 32, 9 June 2026.This study demonstrates significantly reduced Lkb1 expression in CD11c+ cells in chronic pancreatitis (CP) patients and animal models. Lkb1 deletion enhances CD11c+CD206+ macrophage infiltration and reprograms pancreatic stellate cells (PSCs) via OSM signaling.
Wenqing Zhang +10 more
wiley +1 more source
CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.LPS triggers neuroinflammation within the central nervous system. Conversely, the activation of LRP1 by SP16 mitigates insulin resistance, improves glucose metabolism, and facilitates the polarization of microglia toward an anti‐inflammatory M2‐like phenotype, which collectively contribute to the restoration of cognitive function.
Mengyao Qu +9 more
wiley +1 more source
Integrating polygenic and methylation risk scores for pleural mesothelioma risk stratification
International Journal of Cancer, Volume 158, Issue 11, Page 2866-2879, 1 June 2026.What's new? Asbestos exposure is a major risk factor for pleural mesothelioma (PM). Most asbestos‐exposed individuals do not develop PM, suggesting that it arises from a complex interplay between environmental and genetic factors. This study examined the utility of polygenic risk scores (PRS) and methylation risk scores (MRS) in incorporating genetic ...
Khadija Sana Hafeez +26 more
wiley +1 more source
MicrobiologyOpen, Volume 15, Issue 3, June 2026.A large intracellular drug‐repurposing screen identifies a potent synergy between 5‐fluoro‐2′‐deoxycytidine and rifapentine, acting through dual host–pathogen targeting to reduce Staphylococcus aureus burdens across strains, cell types, and infection models (created with BioRender).
Blanca Lorente‐Torres +13 more
wiley +1 more source