Results 141 to 150 of about 36,298 (238)

Insufficient Expression of the Autophagic Protein ATG16L1 Results in Accelerated Carcinogenesis Related to an Aberrant B Cell Response

Cancer Reports, Volume 9, Issue 2, February 2026.
ABSTRACT Background Autophagy‐related proteins (ATGs) regulate a great variety of cellular responses beyond autophagy. In cancer, the role of ATG proteins is central, as evidenced in spontaneous cancer emerging in animals lacking ATG proteins. Aim To determine whether ATG16L1 may be participating in tumorigenesis in colonic and oral mucosa and its ...
Daniela Mendiola, Betsaida Ortiz, Oscar Nieto, Marisol I. González, Danielle Vannan, Bertus Eksteen, Alejandro Martínez, Diego Mateos, Mónica G. Mendoza‐Rodríguez, Miriam Rodríguez‐Sosa, Luis I. Terrazas, José L. Reyes   +11 more
wiley   +1 more source

Aerobic Exercise Promotes Hippocampal Neurogenesis and Ameliorates Cognitive Dysfunction Induced by Unilateral Labyrinthectomy

CNS Neuroscience &Therapeutics, Volume 32, Issue 2, February 2026.
UL induced significant spatial and non‐spatial cognitive dysfunction and hippocampal neurogenesis inhibition, whereas aerobic exercise intervention effectively reversed these impairments. Transcriptomic profiling and pharmacological evidence identified MHC class I/II–related pathways (H2‐K1, H2‐Eb1, CD74) as key mediators of the restorative effects of ...
Zhanghong Zhou, Xixi Yu, E. Tian, Zhaoqi Guo, Jingyu Chen, Jiaqi Guo, Shiyu Shi, Wandi Xu, Ni Zhai, Caijuan Qiao, Yuejin Zhang, Jun Wang, Yisheng Lu, Sulin Zhang   +13 more
wiley   +1 more source

TREM2 Facilitates Myelin Debris Clearance but Exacerbates Chronic Inflammation and Fibrosis After Spinal Cord Injury

CNS Neuroscience &Therapeutics, Volume 32, Issue 2, February 2026.
After spinal cord injury (SCI), TREM2 promotes myelin debris clearance and disease‐associated microglia (DAM) activation that support early repair. However, sustained TREM2‐dependent DAM activation may aggravate chronic inflammation and fibrosis, whereas TREM2 deficiency alleviates these effects, identifying TREM2 as a key regulator of microglial ...
Zhonghan Wu, Shuisheng Yu, Yixue Hu, Xuyang Hu, Linhan Yang, Yan Jiang, Mengdi Zhang, Yiyang Mu, Ziyu Li, Fei Yao, Dasheng Tian, Juehua Jing, Li Cheng   +12 more
wiley   +1 more source

Beyond bacterial defences: the role of lysozyme in cancer

Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.
Lysozyme (LYZ) is a multi‐functional secreted factor that encompasses both antibacterial and immunomodulatory functions. Emerging evidence highlights its complex role in tumour progression by directly influencing tumour cells and modulating the immune microenvironment.
Lei Wang, Qian Dong, Fuchu He, Zhiwen Gu, Aihua Sun   +4 more
wiley   +1 more source

Metabolic reprogramming of efferocytosis in the tumour microenvironment: From apoptotic‐cell clearance to therapeutic targeting

Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.
This review systematically deconstructs the pathological efferocytic—metabolic axis in tumours, framing it as a three‐stage, self‐reinforcing cycle: from metabolite‐driven macrophage recruitment, through hijacked surface recognition, to post‐phagocytic metabolic reprogramming that locks in immunosuppression.
Qianlu Yang, Jie Yan, Qianxi Yang
wiley   +1 more source

Mycobacterium tuberculosis VII secretion system effector molecule Rv2347c blocks the maturation of phagosomes and activates the STING/TBK1 signaling pathway to inhibit cell autophagy

Microbiology Spectrum
The VII secretion system is the main channel for Mycobacterium tuberculosis (MTB) to secrete virulence proteins. The ESAT-like proteins EsxA/B and EsxW/V in the RD region of its genome have been used as targets for vaccine antigens. However, the function
Zhiyong Jiang, Junfeng Zhen, Yuerigu Abulikena, Chaoyun Gao, Lingxi Huang, Tingting Huang, Jianping Xie   +6 more
doaj   +1 more source

Coevolution and Functional Effects of Endosymbiotic Rickettsia in Leptocybe invasa Fisher & LaSalle (Hymenoptera: Eulophidae) Across China

Ecology and Evolution, Volume 16, Issue 2, February 2026.
Two distinct lineages of L. invasa and the dominant endosymbiont, Rickettsia, was identified, followed by an analysis of its infection density across various developmental stages and tissues of L. invasa. Furthermore, two distinct strains of the Rickettsia endosymbiont were detected, and the phylogenetic relationships between these strains and their L.
Xiu Xu, Leming Zhou, Jinting Xie, Junjue Li, Chunhui Guo, Zhende Yang   +5 more
wiley   +1 more source

Deciphering tuberculosis: lysosome-centric insights into pathogenesis and therapies

Frontiers in Cellular and Infection Microbiology
Tuberculosis is a widely spread disease caused by Mycobacterium tuberculosis (Mtb). The pathogenicity of the pathogen is closely associated with the immune defense mechanisms of the host cells. As key cellular degradation and metabolic centers, lysosomes
Cui Bao, Cui Bao, Yuanyuan Zhang, Yuanyuan Zhang, Jiao Feng, Jiao Feng, Xiuwen Hong, Xiuwen Hong, Nan Gao, Nan Gao, Ganzhu Feng   +10 more
doaj   +1 more source

Advances in the Role of Adipose Tissue in Promoting Injury Repair and Resist Infection

Immunity, Inflammation and Disease, Volume 14, Issue 2, February 2026.
ABSTRACT Background In recent years, adipose tissue (AT) transplantation has increasingly been noticed by many people in the field of tissue repair and regeneration. Accumulating evidence demonstrates that AT exerts dual functions in promoting tissue repair and conferring anti‐infective properties, with distinct biological effects attributed to its ...
Xi Duan, Run Li, Lei Fu, Jiali Yang, Zhean Zhan   +4 more
wiley   +1 more source

PIPs propel phagosomes

Journal of Cell Biology, 2010
![Figure][1] Phagosomes formed via the CR3 receptor assemble an actin comet tail (arrow, left), whereas FcgR phagosomes do not (right). Bohdanowicz et al. describe how different phosphatidylinositol phosphates (PIPs) promote actin polymerization on specific phagosome membranes to move ...
openaire   +2 more sources