The role of the host—Neutrophil biology
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple +4 more
wiley +1 more source
EhVps32 Is a Vacuole-Associated Protein Involved in Pinocytosis and Phagocytosis of Entamoeaba histolytica. [PDF]
Here, we investigated the role of EhVps32 protein (a member of the endosomal-sorting complex required for transport) in endocytosis of Entamoeba histolytica, a professional phagocyte.
Yunuen Avalos-Padilla +7 more
doaj +1 more source
Understanding of how intracellular pathogens survive in their host cells is important to improve management of their diseases. This has been fruitful for intracellular bacteria, but it is an understudied area in fungal pathogens.
Emmanuel J. Santiago-Burgos +4 more
doaj +1 more source
Polymorphonuclear leukocytes obtained from sterile peritoneal exudates in rabbits contain two phospholipid-splitting activities (phosphatidylacylhydrolases EC 3.1.1.4), one most active at pH 5.5 and the other between pH 7.2 and 9.0.
R. Franson, P. Patriarca, P. Elsbach
doaj +1 more source
Changes to cholesterol trafficking in macrophages by Leishmania parasites infection [PDF]
Leishmania spp. are protozoan parasites that are transmitted by sandfly vectors during blood sucking to vertebrate hosts and cause a spectrum of diseases called leishmaniases.
Anderson +67 more
core +2 more sources
Rab20 regulates phagosome maturation in RAW264 macrophages during Fc gamma receptor-mediated phagocytosis. [PDF]
Rab20, a member of the Rab GTPase family, is known to be involved in membrane trafficking, however its implication in FcγR-mediated phagocytosis is unclear.
Youhei Egami, Nobukazu Araki
doaj +1 more source
Novel transmembrane receptor involved in phagosome transport of lysozymes and β-hexosaminidase in the enteric protozoan Entamoeba histolytica. [PDF]
Lysozymes and hexosaminidases are ubiquitous hydrolases in bacteria and eukaryotes. In phagocytic lower eukaryotes and professional phagocytes from higher eukaryotes, they are involved in the degradation of ingested bacteria in phagosomes.
Atsushi Furukawa +2 more
doaj +1 more source
Determinants of Phagosomal pH During Host-Pathogen Interactions
The ability of phagosomes to halt microbial growth is intimately linked to their ability to acidify their luminal pH. Establishment and maintenance of an acidic lumen requires precise co-ordination of H+ pumping and counter-ion permeation to offset the ...
Johannes Westman +2 more
doaj +1 more source
Biocompatibility and tissue regenerating capacity of crosslinked dermal sheep collagen [PDF]
The biocompatibility and tissue regenerating capacity of four crosslinked dermal sheep collagens (DSC) was studied. In vitro, the four DSC versions were found to be noncytotoxic or very low in cytoxicity.
Anselme +36 more
core +2 more sources
Francisella tularensisPhagosomal Escape Does Not Require Acidification of the Phagosome [PDF]
ABSTRACTFollowing uptake,Francisella tularensisenters a phagosome that acquires limited amounts of lysosome-associated membrane glycoproteins and does not acquire cathepsin D or markers of secondary lysosomes. With additional time after uptake,F. tularensisdisrupts its phagosomal membrane and escapes into the cytoplasm.
Clemens, Daniel L +2 more
openaire +4 more sources

