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Pharmaceutical cocrystals: An overview
International Journal of Pharmaceutics, 2011Pharmaceutical cocrystals are emerging as a new class of solid drugs with improved physicochemical properties, which has attracted increased interests from both industrial and academic researchers. In this paper a brief and systematic overview of pharmaceutical cocrystals is provided, with particular focus on cocrystal design strategies, formation ...
Ning Qiao +2 more
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Recent Advances on the Biological Study of Pharmaceutical Cocrystals
AAPS PharmSciTech, 2022As a low-risk, low-cost, but high-reward route, cocrystallization of drugs with appropriate coformers is applied to improve the physiochemical and biopharmaceutical properties of drugs. Currently, most researchers concentrate their efforts on the preparation, characterization, and improvement of physicochemical properties of pharmaceutical cocrystals ...
Zhipeng Wang +2 more
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Pharmaceutical cocrystals and poorly soluble drugs
International Journal of Pharmaceutics, 2013In recent years cocrystal formation has emerged as a viable strategy towards improving the solubility and bioavailability of poorly soluble drugs. In this review the success of numerous pharmaceutical cocrystals for the improvement of the solubility and dissolution rates of poorly soluble drugs is demonstrated using various examples taken from the ...
Ranjit Thakuria +2 more
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Pharmaceutical Cocrystals of Diflunisal and Diclofenac with Theophylline
Molecular Pharmaceutics, 2014Pharmaceutical cocrystals of nonsteroidal anti-inflammatory drugs diflunisal (DIF) and diclofenac (DIC) with theophylline (THP) were obtained, and their crystal structures were determined. In both of the crystal structures, molecules form a hydrogen bonded supramolecular unit consisting of a centrosymmetric dimer of THP and two molecules of active ...
Artem O Surov +2 more
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Challenges in Translational Development of Pharmaceutical Cocrystals
Journal of Pharmaceutical Sciences, 2017The last 2 decades have witnessed increased research in the area of cocrystals resulting in deeper scientific understanding, increase in intellectual property landscape, and evolution in the regulatory environment. Pharmaceutical cocrystals have received significant attention as a new solid form on account of their ability to modulate poor ...
Dnyaneshwar P Kale, Arvind K Bansal
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Crystal Engineering of Pharmaceutical Cocrystals [PDF]
, 2011 Cocrystals have recently gained attention as attractive alternate solid forms for drug development. A pharmaceutical cocrystal is a single crystalline homogenous phase consisting of a drug molecule and ligand i.e. cocrystal former that is excipient or another drug molecule [1,2].
Cvetkovski, Aleksandar, Gulaboski, Rubin
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Stability screening of pharmaceutical cocrystals
Pharmaceutical Development and Technology, 2021An efficient protocol for assessing both the chemical and physical stability of cocrystalline forms of active pharmaceutical ingredients (APIs) is proposed. In this protocol, the cocrystalline material is used to prepare two standard formulations, mimicking wet granulations, to make low-dose tablets.
Kenneth C, Waterman +5 more
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Cocrystal: A Review on the Design and Preparation of Pharmaceutical Cocrystals
Asian Journal of Research in Pharmaceutical Sciences, 2023The majority of the active pharmaceutical components have issues with poor solubility, bioavailability, chemical stability, and moisture absorption. Pharmaceutical crystals are a reliable way to change the aforementioned physicochemical properties of drugs without changing their pharmacological behaviour.
Tanmay Jit +4 more
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