Results 141 to 150 of about 2,349 (173)
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The role of cocrystals in pharmaceutical science
Drug Discovery Today, 2008Pharmaceutical cocrystals, a subset of a long known but little-studied class of compounds, represent an emerging class of crystal forms in the context of pharmaceutical science. They are attractive to pharmaceutical scientists because they can significantly diversify the number of crystal forms that exist for a particular active pharmaceutical ...
Ning, Shan, Michael J, Zaworotko
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Pharmaceutical cocrystals: walking the talk
Chemical Communications, 2016From Saridon to Entresto: the journey of pharmaceuticals from the first drug–drug combination of propyphenazone and pyrithyldione in 1937 (left) to the most recent monosodium sacubitril and disodium valsartan in 2015 (right).
Geetha, Bolla, Ashwini, Nangia
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Crystal Engineering of Pharmaceutical Cocrystals
, 2013 In the last years, the design and synthesis of co-crystals containing active pharmaceutical ingredients (APIs) has become the new frontier of the crystal engineering due to the great opportunity to modify the physico-chemical properties of solid forms of drugs.
FERRETTI, Valeria
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Pharmaceutical Cocrystals of Niclosamide
Crystal Growth & Design, 2012Niclosamide (NCL) is an anthelmintic BCS class II drug of low solubility and high permeability. Pharmaceutical cocrystals of NCL were prepared with GRAS molecules, such as caffeine (CAF), urea (URE), p-aminobenzoic acid (PABA), theophylline (THPH), nicotinamide (NCT), and isonicotinamide (INA), to improve drug solubility. Neat grinding, wet granulation,
Palash Sanphui +2 more
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Pharmaceutical Cocrystal: An Antique and Multifaceted Approach
Current Drug Delivery, 2017Pharmaceutical cocrystal is an emerging approach to tailor physicochemical and mechanical properties of drug substances. Cocrystals are composed of API and pharmaceutically acceptable coformer. It is used to address the solubility, dissolution, mechanical properties and stability of drugs.This review discusses introduction to cocrystal, preparation ...
Prabhakar S, Panzade +1 more
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Changes in the proportions of an active pharmaceutical through cocrystals
Drug Development Research, 2021AbstractIn this study, the modulation of amounts sulfathiazolium cations in different 2,6‐pyridinedicarboxylates is demonstrated. An uncommon monoionic sulfathiazolium zinc 2,6‐pyridinedicarboxylate (1:1 electrolyte) complex was characterized. Conventional sulfathiazolium zinc‐bis‐2,6‐pyridinedicarboxylate dianionic complexes (2:1 electrolyte) were ...
Abhay Pratap Singh +2 more
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2017
The aim of this project is to improve cocrystal screening and solubility prediction methods.
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The aim of this project is to improve cocrystal screening and solubility prediction methods.
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Multicomponent pharmaceutical cocrystals: furosemide and pentoxifylline
Acta Crystallographica Section C Crystal Structure Communications, 2012The combination of the active pharmaceutical ingredients furosemide [4-chloro-2-(furan-2-ylmethylamino)-5-sulfamoylbenzoic acid] and pentoxifylline [3,7-dimethyl-1-(5-oxohexyl)-3,7-dihydro-1H-purine-2,6-dione] produces a 1:1 cocrystal, C12H11ClN2O5S·C13H18N4O3, (I), a 1:1 cocrystal hydrate, C12H11ClN2O5S·C13H18N4O3·H2O, (II), and a 1:1 cocrystal ...
Dmitrijs, Stepanovs, Anatoly, Mishnev
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Pharmaceutical Cocrystal and Salts of Norfloxacin
Crystal Growth & Design, 2006The aim of this study was to investigate the structural and pharmaceutical properties of norfloxacin (a poorly soluble antibacterial drug), its cocrystal, and salts. Norfloxacin in the anhydrous form (form A, 1) was crystallized. It was cocrystallized with isonicotinamide (2), and organic salts were prepared with succinic acid, malonic acid, and maleic
Srinivas Basavoju +2 more
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Pharmaceutical Cocrystals of Famotidine: Structural and Biopharmaceutical Evaluation
Journal of Pharmaceutical Sciences, 2022Famotidine (FMT) an anti-ulcer drug, recently being repurposed in COVID-19 treatment, suffers from poor aqueous solubility and restricted bioavailability (
Akshita Jindal +6 more
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